Determination of free phenolic acids and antioxidant activity of methanolic extracts obtained from fruits and leaves of Chenopodium album

Laghari, Abdul Hafeez; Memon, Shahabuddin; Nelofar, Aisha; Khan, Khalid Mohammed; Yasmin, Arfa

doi:10.1016/j.foodchem.2010.11.165

Cited by 94 publications

(51 citation statements)

References 23 publications

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“…In the seventh week, there was no significant difference (p>0.05) between the control and BHA treated samples. This was unexpected because BHA has been reported to be a potent synthetic antioxidant (Mariod et al, 2012;Laghari et al, 2011). There was no significant difference among all levels of Moringa and salt treated samples in the seventh week.…”

Section: Resultsmentioning

confidence: 88%

LIPID PEROXIDATION IN SMOKE-DRIED AFRICAN CATFISH TREATED WITH Moringa oleifera MARINADE, SALT OR BUTYLATED HYDROXYL ANISOLE

Adeyemi¹,

El-Imam²,

Olorunsanya³

et al. 2014

CJF

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Smoke-dried fish is vulnerable to lipid peroxidation, which can reduce product quality and pose health risks to consumers. The study examined the antioxidant potency of Moringa oleifera marinade on oxidative stability of smoke-dried catfish in comparison with salt and Butylated hydroxyl anisole (BHA), a synthetic antioxidant. Seventy-two catfish (208±6 g) were processed, randomly assigned to six antioxidant treatment groups and hot smoked. The treatments are the control (0%), 1%, 2% and 3% (w/v) Moringa oleifera marinade (MOM), 5% Brine (w/v) and 0.2% BHA (w/v). The smoke-dried fish were stored at room temperature (35±1 0 C) for 8 weeks. Lipid peroxidation was monitored weekly using Thiobarbituric acid (TBA) assay. The results showed that Moringa oleifera marinade and BHA decreased lipid peroxidation more than (p<0.05) the control (0.94 mg/MDA/ kg) and salt (0.92 mg/MDA/kg) treated samples. This was shown by the lower Thiobarbituric acid reactive substance (TBARS) values of 1% MOM (0.84 mg/MDA/kg), 2% MOM (0.88 mg/MDA/kg), 3% MOM (0.85 mg/ MDA/kg) and BHA (0.80 mg/MDA/kg) treated samples. A general increase in oxidative spoilage was observed for all treatments as storage time progressed. However, the increment was more (p<0.05) intense in control and salt treated samples. No significant (p>0.05) difference was observed among all Moringa treated samples and BHA. Moringa oleifera marinade could be used as an alternative to BHA in suppressing lipid peroxidation in smoke-dried African catfish stored for 8 weeks.

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Section: Resultsmentioning

confidence: 88%

LIPID PEROXIDATION IN SMOKE-DRIED AFRICAN CATFISH TREATED WITH Moringa oleifera MARINADE, SALT OR BUTYLATED HYDROXYL ANISOLE

Adeyemi¹,

El-Imam²,

Olorunsanya³

et al. 2014

CJF

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“…The mobile phase was water containing 2% acetic acid (A) and methanol (B). The composition gradient was 5% of B to 2 min, when it was changed to obtain 25%, 40%, 50%, 60%, 70%, and 100% B at 10,20,30,40,50, and 80 min, respectively, following the method described by Laghari et al (2011) with slight modifications. The extracts were analyzed at a concentration of 0.150 mg/ mL.…”

Section: Analysis Of Phenolic Compoundsmentioning

confidence: 99%

Evaluation of basil extract ( Ocimum basilicum L.) on oxidative, anti-genotoxic and anti-inflammatory effects in human leukocytes cell cultures exposed to challenging agents

Güez

Souza

Fischer

et al. 2017

Braz. J. Pharm. Sci.

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Ocimum is one of the most important genera of the Lamiaceae family. Several studies about basil and its popular use reveal many characteristics of the herb, including its use as antioxidant, anti-aging, antiinflammatory, anti-carcinogenic, anti-microbial, and cardiovascular agents, among others. In this paper, we evaluated genotoxic, oxidative, and anti-inflammatory parameters from the extract of Ocimum basilicum in different concentrations, using human leukocytes cultures exposed to challenging agents. Our results confirm that the O. basilicum extract acts as an antioxidant and effectively reverts or subjugates the effects of high oxidizing agents such as hydrogen peroxide. These actions are attributed to its composition, which is rich in polyphenols and flavonoids as well as compounds such as rosmarinic acid, all of which have well-known antioxidant activity. We also show that our basil extract presents anti-inflammatory properties, the mechanism of which is a composed interaction between the inhibition of pro-inflammatory mediator and the stimulation of anti-inflammatory cytokines. Although pharmacodynamics studies are necessary to evaluate the activities in vivo, our results demonstrated that basil could act as an antioxidant and anti-inflammatory and a possible alternative for medicinal treatment. Uniterms:Ocimum basilicum/evaluation. Ocimum basilicum/genotoxic effects. Ocimum basilicum/ anti-inflammatory properties. Medicinal plants/study.

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“…Qualitative and quantitative analyses of phenolics and flavonoids compounds by HPLC-DAD Reverse phase chromatographic analyses were carried out under gradient conditions using C 18 column (4.6 mm Â250 mm) packed with 5 lm diameter particles; the mobile phase was water containing 2% acetic acid (A) and methanol (B), and the composition gradient was: 5% of B until 2 min and changed to obtain 25%, 40%, 50%, 60%, 70% and 100% B at 10, 20, 30, 40, 50 and 80 min, respectively, following the method described by Laghari et al (2011) with slight modifications. The hydroalcoholic extract of the C. campestris was analysed, dissolved in ethanol at a concentration of 5 mg/mL.…”

Section: Chemical Profilementioning

confidence: 99%

Oxidant effects and toxicity of Croton campestris in Drosophila melanogaster

Júnior

Macedo

Zemolin

et al. 2016

Pharmaceutical Biology

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Context: Croton campestris A.St.-Hil. (Euphorbiaceae) is a species native to Northeast Brazil used by traditional communities for the treatment of a variety of health problems. However, potential toxicological effects of this plant are unknown. Objective: The potential toxicity of the hydroalcoholic extract of C. campestris leaves on Drosophila melanogaster insect model, additionally with phytochemical constitution and cellular mechanisms mediating the action of extract were analysed in this study. Materials and methods: Constituents of the extract were evaluated by HPLC. In vitro antioxidant potential of extract was analysed by DPPH, ABTS and FRAP. Flies injected culture medium mixed with extract (0.1-50 mg/mL) for 72 h. After, ROS production was evaluated by DCF-DA oxidation. Phosphorylation of MAPK signalling pathway was investigated by Western blotting method. Activity of antioxidant enzymes was analysed in homogenates.Results: Major components of the extract include quercetin (38.11 ± 0.06 mg/g), caffeic acid (20.06 ± 0.17 mg/g) and kaempferol (15.45 ± 0.05 mg/g). Consumption of the extract impaired locomotor performance and induced fly death of flies (LC 50 of 26.51 mg/mL). Augmented ROS formation and SOD, CAT and GST activity were observed from 0.1 mg/mL. JNK and p38 kinases phosphorylation was modulated and Paraquat-induced toxicity was augmented by extract. Discussion and conclusion: Our data show important toxicological effects of C. campestris leading to increased mortality and impaired locomotor performance accompanied by induction of cell stress markers in flies. The study draws attention to the indiscriminate use of plant extracts. ARTICLE HISTORY

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Determination of free phenolic acids and antioxidant activity of methanolic extracts obtained from fruits and leaves of Chenopodium album

Cited by 94 publications

References 23 publications

LIPID PEROXIDATION IN SMOKE-DRIED AFRICAN CATFISH TREATED WITH Moringa oleifera MARINADE, SALT OR BUTYLATED HYDROXYL ANISOLE

LIPID PEROXIDATION IN SMOKE-DRIED AFRICAN CATFISH TREATED WITH Moringa oleifera MARINADE, SALT OR BUTYLATED HYDROXYL ANISOLE

Evaluation of basil extract ( Ocimum basilicum L.) on oxidative, anti-genotoxic and anti-inflammatory effects in human leukocytes cell cultures exposed to challenging agents

Oxidant effects and toxicity of Croton campestris in Drosophila melanogaster

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