Determination of free Bisphenol A (BPA) concentrations in breast milk of U.S. women using a sensitive LC/MS/MS method

Zimmers, Stephanie M.; Browne, Eva P.; O’Keefe, Patrick; Anderton, Douglas L.; Kramer, Lawrence; Reckhow, David A.; Arcaro, Kathleen F.

doi:10.1016/j.chemosphere.2013.12.085

Cited by 155 publications

(65 citation statements)

References 37 publications

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“…Despite the great improvement in ESI+ ionization of the resulting BPA derivative, the MS/MS fragmentation of the resulting ion yields only reagent‐specific product ions, which drastically reduces the specificity of the method. Chemical derivatization using pyridine‐3‐sulfonyl (PS) chloride has been very recently applied for the determination of BPA in different kinds of biological matrices with successful results with regard to both sensitivity and specificity 23, 24, 25, 26. This derivatization reagent has been reported to present a major advantage over the widely used dansyl chloride, since MS/MS transitions involve analyte‐specific product ions rather than reagent‐specific product ions 23, 24, 27.…”

mentioning

confidence: 99%

Derivatization of bisphenol A and its analogues with pyridine‐3‐sulfonyl chloride: multivariate optimization and fragmentation patterns by liquid chromatography/Orbitrap mass spectrometry

Regueiro

Andreas

Wenzl

2015

Rapid Commun. Mass Spectrom.

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RationaleDue to the growing restrictions on the use of bisphenol A (BPA), several other bisphenols are gaining importance as substitutes for BPA in a variety of applications. There is, therefore, a real need for selective and sensitive methods based on mass spectrometry which will allow the human exposure to these new bisphenols to be assessed.MethodsDerivatization of BPA and its substitutes with pyridine‐3‐sulfonyl chloride is used to enhance the detection capability of bisphenols by electrospray ionization mass spectrometry. A multivariate experimental design, Box‐Behnken response surface, was used to evaluate the influence of the main variables potentially affecting the derivatization yield. Fragmentation patterns for all the derivatized bisphenols were acquired by high‐resolution/accurate‐mass Orbitrap mass spectrometry.ResultsTemperature and pH were identified as the most important factors affecting the derivatization yield of bisphenols. Fragmentation of the protonated molecules produced abundant analyte‐specific product ions. Most of the derivatized bisphenols showed significant improvements in their signal‐to‐noise ratios compared with the underivatized forms. The stability of these derivatives was demonstrated through several freeze/thaw cycles, short‐term room temperature and long‐term cold storage.ConclusionsDerivatization of BPA and its structural analogues with pyridine‐3‐sulfonyl chloride is proposed as a specific, sensitive, high‐throughput approach to their analysis by liquid chromatography coupled to electrospray ionization mass spectrometry. © 2015 The Authors. Rapid Communications in Mass Spectrometry Published by John Wiley & Sons Ltd.

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confidence: 99%

Derivatization of bisphenol A and its analogues with pyridine‐3‐sulfonyl chloride: multivariate optimization and fragmentation patterns by liquid chromatography/Orbitrap mass spectrometry

Regueiro

Andreas

Wenzl

2015

Rapid Commun. Mass Spectrom.

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“…Inoue et al (2004) showed PFOS blood concentrations in pregnant humans of 4.9-17.6ng/ml and 1.6-5.3ng/ml in the developing foetus, indicating the placental barrier is not entirely effective at removing certain amphipathic PFCs. Zimmers et al (2014) have also been detected in human breast milk (Lankova et al 2013). Here, eight perfluoroalkyl compounds were detected in the breast milk of 50 humans including PFOA (0.012-0.128ng/ml), PFOS (0.007-0.114pg/ml) and PFNA (<0.006-0.015ng/ml) as well as TBBPA at levels of <0.060-16.2ng/ml (Lankova et al 2013).…”

Section: Occurrence and Possible Effects Of Pcps/ecs In Humansmentioning

confidence: 87%

Ecotoxic pharmaceuticals, personal care products, and other emerging contaminants: A review of environmental, receptor-mediated, developmental, and epigenetic toxicity with discussion of proposed toxicity to humans

Wilkinson

Hooda

Barker

et al. 2015

Critical Reviews in Environmental Science and Technology

163

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“…As listed from Table S1, methods like HPLC [19,38], GC-MS [21], LC/MS [20] and LC-MS/MS [39] can detect BPA with high sensitivity and selectivity, but they require complicated instruments and highly trained operators. The electrochemistry methods [40,41] show low detection limit and broad linear range, but possibly involve the disadvantages of instability and interference of organics in anodic/catholic stripping voltammetry.…”

Section: Methods Performance Comparisonmentioning

confidence: 99%

“…For that reason, the identification and determination of trace amounts of BPA is very necessary. The most frequently used methods include high performance liquid chromatography (HPLC) [19], high performance liquid chromatography-mass spectrometry (MS) [20], and gas chromatography-mass spectrometry (GC-MS) [21]. However, these methods are still involved in some problems such as complex instruments, high cost, time-consuming, and particularly low selectivity.…”

Section: Introductionmentioning

confidence: 99%

Molecularly imprinted polymers-coated gold nanoclusters for fluorescent detection of bisphenol A

Zhong

et al. 2015

Sensors and Actuators B: Chemical

112

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a b s t r a c tA flexible fluorescent sensing strategy for the recognition and detection of bisphenol A (BPA) has been proposed based on molecularly imprinted polymers (MIPs)-coated gold nanoclusters (AuNCs), by taking advantages of the high selectivity of MIPs and the strong fluorescence property of AuNCs. SiO 2 @AuNCs were initially prepared by making use of the powerful amido bonds between carboxyl-terminated AuNCs and amino-functionalized SiO 2 nanoparticles. Then MIPs-coated AuNCs were formed by anchoring MIP layer on the surface of SiO 2 @AuNCs via a sol-gel process. In the presence of imprinting template BPA, a Meisenheimer complex could be formed between BPA and the primary amino groups on the surface of the AuNCs, and the photoluminescent energy of AuNCs would be transferred to the complex, and thereby result in the fluorescence quenching of AuNCs. The fluorescence-quenching fractions of the sensor presented a satisfactory linearity with BPA concentrations over the range of 0-13.1 M and the detection limit could reach 0.10 M. Distinguished selectivity was also exhibited to BPA over other possibly competing molecules. Moreover, the sensor was successfully applied to determine BPA in seawater, and the average recoveries of BPA at three spiking levels ranged from 91.3 to 96.2% with relative standard deviations below 4.8%. This AuNCs-MIPs based sensor provided great potentials for recognition and determination of phenolic environmental estrogens in complicated samples.

show abstract

Determination of free Bisphenol A (BPA) concentrations in breast milk of U.S. women using a sensitive LC/MS/MS method

Cited by 155 publications

References 37 publications

Derivatization of bisphenol A and its analogues with pyridine‐3‐sulfonyl chloride: multivariate optimization and fragmentation patterns by liquid chromatography/Orbitrap mass spectrometry

Derivatization of bisphenol A and its analogues with pyridine‐3‐sulfonyl chloride: multivariate optimization and fragmentation patterns by liquid chromatography/Orbitrap mass spectrometry

Ecotoxic pharmaceuticals, personal care products, and other emerging contaminants: A review of environmental, receptor-mediated, developmental, and epigenetic toxicity with discussion of proposed toxicity to humans

Molecularly imprinted polymers-coated gold nanoclusters for fluorescent detection of bisphenol A

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