a Molecular imprinting technology (MIT), often described as a method of making a molecular lock to match a molecular key, is a technique for the creation of molecularly imprinted polymers (MIPs) with tailor-made binding sites complementary to the template molecules in shape, size and functional groups. Owing to their unique features of structure predictability, recognition specificity and application universality, MIPs have found a wide range of applications in various fields. Herein, we propose to comprehensively review the recent advances in molecular imprinting including versatile perspectives and applications, concerning novel preparation technologies and strategies of MIT, and highlight the applications of MIPs. The fundamentals of MIPs involving essential elements, preparation procedures and characterization methods are briefly outlined.Smart MIT for MIPs is especially highlighted including ingenious MIT (surface imprinting, nanoimprinting, etc.), special strategies of MIT (dummy imprinting, segment imprinting, etc.) and stimuli-responsive MIT (single/dual/ multi-responsive technology). By virtue of smart MIT, new formatted MIPs gain popularity for versatile applications, including sample pretreatment/chromatographic separation (solid phase extraction, monolithic column chromatography, etc.) and chemical/biological sensing (electrochemical sensing, fluorescence sensing, etc.). Finally, we propose the remaining challenges and future perspectives to accelerate the development of MIT, and to utilize it for further developing versatile MIPs with a wide range of applications (650 references).
Photodynamic therapy (PDT) efficacy has been severely limited by oxygen (O2) deficiency in tumors and the electron–hole separation inefficiency in photosensitizers, especially the long‐range diffusion of O2 toward photosensitizers during the PDT process. Herein, novel bismuth sulfide (Bi2S3)@bismuth (Bi) Z‐scheme heterostructured nanorods (NRs) are designed to realize the spatiotemporally synchronous O2 self‐supply and production of reactive oxygen species for hypoxic tumor therapy. Both narrow‐bandgap Bi2S3 and Bi components can be excited by a near‐infrared laser to generate abundant electrons and holes. The Z‐scheme heterostructure endows Bi2S3@Bi NRs with an efficient electron–hole separation ability and potent redox potentials, where the hole on the valence band of Bi2S3 can react with water to supply O2 for the electron on the conduction band of Bi to produce reactive oxygen species. The Bi2S3@Bi NRs overcome the major obstacles of conventional photosensitizers during the PDT process and exhibit a promising phototherapeutic effect, supplying a new strategy for hypoxic tumor elimination.
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