2010
DOI: 10.1016/j.jchromb.2009.11.036
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Determination of free and liposomal Amphotericin B in human plasma by liquid chromatography–mass spectroscopy with solid phase extraction and protein precipitation techniques

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Cited by 71 publications
(42 citation statements)
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“…Analytical methods for the measurement of released and encapsulated drugs in plasma samples have previously been reported. However, these methods need complex sample preparation procedures, such as ultracentrifugation, 16) solid phase extraction (SPE), [17][18][19][20] gel filtration 17) or ultrafiltration 21) before analysis. These separation methods have a potential risk of sample deterioration: adsorption to ultrafiltration devices, high sample dilution during gel chromatography, and drug release from the liposomes during reversed phase SPE.…”
Section: Development Of Analytical Methods To Ensure the Quality Of Dmentioning
confidence: 99%
“…Analytical methods for the measurement of released and encapsulated drugs in plasma samples have previously been reported. However, these methods need complex sample preparation procedures, such as ultracentrifugation, 16) solid phase extraction (SPE), [17][18][19][20] gel filtration 17) or ultrafiltration 21) before analysis. These separation methods have a potential risk of sample deterioration: adsorption to ultrafiltration devices, high sample dilution during gel chromatography, and drug release from the liposomes during reversed phase SPE.…”
Section: Development Of Analytical Methods To Ensure the Quality Of Dmentioning
confidence: 99%
“…Sample preparation for free AMP-B includes SPE while liposomal AMP-B is extracted by LLE from the SPE flow-through. The linear range is 0.27-16.23 mmol/L (0.25-15.0 mg/mL) and the CV is 1.4-6.3% for free AMP-B, while 1.08-108.22 mmol/L (1.0-100.0 mg/mL) and 4.0-8.9% for liposomal AMP-B, respectively [15]. [7,8], plasma [5,6,8] Chromolith Performance RP-18e (100 Â 4.6 mm) [5,6,8], Chromolith (50 Â 4.6 mm) [7] Clobazam, N-desmethylclobazam [5] lamotrigine [7,8], phenytoin [8], carbamazepine-10,11-expoide [8], felbamate [8], dihydro-10-hydroxycarbamazepine [8], phentobarbital [8], phenobarbital [8], carbamazepine [8], primidone [8], zonisamide [8] [ [9,10,15,20] Plasma [9, 10, 13-15, 17, 20], serum [12], CSF [14], dried blood spots [16], urine [12,18], whole blood [19] Chromolith C18 (100 Â 4.6 mm) [9], Chromolith Performance RP-18e (100 Â 4.6 mm) [10,[13][14][15],…”
Section: Antibiotics Antiviral Antifungal and Antimalarial Drugsmentioning
confidence: 96%
“…Therefore, patients are monitored during the intravenous delivery to determine the amount of free and liposomal AMP-B. Plasma AMP-B was separated on a monolithic column in 6.5 min and was detected by LC-MS/MS [15]. Sample preparation for free AMP-B includes SPE while liposomal AMP-B is extracted by LLE from the SPE flow-through.…”
Section: Antibiotics Antiviral Antifungal and Antimalarial Drugsmentioning
confidence: 99%
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“…With the purpose of defining the drug content of nanoparticles, a quantitation method must be appropriately validated. Various methods have been described in the literature for determining the AmB content in samples, such as the use of biological matrices, high performance liquid chromatography (HPLC) (Italia, Singh, Kumar, 2009;Espada et al, 2008;Eldem, Arican-Cellat, 2001), second-derivative spectrophotometry (Ganière Monteil et al, 1998), and liquid chromatography tandem mass spectrometry (LC-MS/MS) (Deshpande et al, 2010). In lipid formulations, HPLC (Manosroi, Kongkaneramit, Manosroi, 2004a;Manosroi, Kongkaneramit, Manosroi, 2004b;Eldem, Arican-Cellat, 2000) and UV/Vis-spectrophotometry (Legrand et al, 1997;Larabi et al, 2004;Jung et al, 2009) have been reported.…”
Section: Introductionmentioning
confidence: 99%