Determination of ephedrine compounds in nutritional supplements by cyclodextrin-modified capillary electrophoresis

Simultaneous Chiral Analysis of Methamphetamine and its Metabolites by Capillary Electrophoresis/Mass Spectrometry with Direct Injection of Urine

“…A number of CE methods have been utilized for the chiral separation of amphetamines in seized drugs etc. [13][14][15][16][17][18] and in urine. [19][20][21][22][23][24] However, these methods for amphetamines in urine require a procedure of extraction from urine and are unsatisfactory with respect to the need for rapid analyses.…”

Chiral analysis of amphetamine‐type stimulants using reversed‐polarity capillary electrophoresis/positive ion electrospray ionization tandem mass spectrometry

“…Capillary electrophoresis (CE) is one of the powerful techniques for separating the enantiomers and can be applied to ATS separation [8][9][10][11][12][13][14][15][16]. We had reported the simultaneous chiral separation of 9 ATS, dl-NEP, dl-NpEP, dl-EP, dl-pEP, dl-amphetamine (AM), dl-MA, dl-methylenediox-yamphetamine (MDA), dl-methylenedioxymethamphetamine (MDMA) and dl-methylenedioxyethylamphetamine (MDEA), by reversed-polarity (RP) CE with a UV detector using highly sulfated g-cyclodextrin (SU(XIII)-g-CD) as a chiral selector [1].…”

Chiral separations in capillary electrophoresis

“…The methods deal with enantiomeric determination of aminophosphoric acids effective in medication of osteoporosis [189], determination of amphetamines and amphetamine analogs in urine and determination of their enantiomeric composition [190], enantiomeric separation of D,L-carnitine [191,192], 2¢-deoxo-3¢-thiacytidine [193] and deprenyl and its major metabolites [194], capillary electrophoretic enantioseparation of ephedrine, selegiline and methamphetamine [195] as well as determination of ephedrine compounds in nutritional supplements [196], determination of fenfluramide enantiomers in pharmaceutical formulations [197], quantitation of l-L-folinic acid in the presence of its pharmaceutically inactive d-L-form in commercial pharmaceutical formulations [198], separation of enantiomers and diastereoisomers of 4-hydroxy-2H-1,4-benzoxazin-3(4H)-one derivatives [199], optimized separation and detection of the enantiomers of isoprotenerol in microdialysis samples [200], chiral separation of lobeline and metoxamine [201] and of local anesthetics [202], ultrafast chiral separations of the basic drugs isoprotenerol and metaprotenerol [203], separation of enantiomers of mianserine analogs [204], muscarinic antagonists [205] as well as the drugs norverapamil and verapamil [206]. Analysis of pilocarpine and its transepimer isopilocarpine serves as routine control of eye drops [207]; chiral differentiation of optical isomers of racemorphan in urine serves for the separation of synthetic analogs of morphine in the forensic control [208].…”