Determination of doxazosin mesylate in tablets by RP-HPLC

Dhanya, B Sen; Suganthi, A; Sen, Dhanya B.; Sahoo, Ujjwal; Seth, A. K.

doi:10.4103/0250-474x.89772

Cited by 8 publications

(5 citation statements)

References 13 publications

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“…[9] Since then, a large number of analogous synthesis methods have been reported. [10][11][12][13][14][15][16] To date, such reactions remain one of the most popular methods for the preparation of 2-pyrazolines. Another method for synthesizing 2-pyrazolines is the reaction of the diazoalkanes with α, β-unsaturated carboxylic acid derivatives [17,18] and α, β-enones (Scheme 1, Route 2).…”

Section: Introductionmentioning

confidence: 99%

“…The synthesis of 2‐pyrazoline derivatives can be traced back to the late 19 th century, when Fischer and Knoevenagel synthesized these compounds through the reaction of α, β‐unsaturated aldehydes and ketones with hydrazines (Scheme 1, Route 1) [9] . Since then, a large number of analogous synthesis methods have been reported [10–16] . To date, such reactions remain one of the most popular methods for the preparation of 2‐pyrazolines.…”

Section: Introductionmentioning

confidence: 99%

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Pyridinium trifluoroacetate ionic liquids as proficient catalysts for synthesis of 3,5,5‐trimethyl‐2‐pyrazoline

Jiao,

Cui,

Liu

et al. 2024

ChemistrySelect

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In this work, pyridinium trifluoroacetate ionic liquids, as a protonic acid catalyst, were used to catalyze intramolecular cyclization of ketazine to synthesize 2‐pyrazoline. The investigation encompassed the impact of temperature, solvent, dosage of ionic liquid catalyst, and the structure‐activity relationship in the cyclization reaction of 2‐propyl ketazine. The optimal catalytic performance was achieved at 100 °C with 8 mol % of 3,5‐dimethylpyridinium trifluoroacetate in a solvent‐free environment. Moreover, thermodynamic and kinetic data were determined through density functional theory calculations and calorimetric experiments. These protonic acid ionic liquids address the issue of excessive traditional protonic acid dosage in the intramolecular cyclization of ketazine, while also presenting a viable pathway for the catalytic synthesis of 2‐pyrazolines.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pyridinium trifluoroacetate ionic liquids as proficient catalysts for synthesis of 3,5,5‐trimethyl‐2‐pyrazoline

Jiao,

Cui,

Liu

et al. 2024

ChemistrySelect

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“…Several analytical procedures have been reported for the analysis of DOX as well as FIN in pharmaceutical preparations using spectrofluorimetric chromatography [16][17][18], reversed-phase high-performance liquid chromatography (RP-HPLC) [19,20], liquid chromatography-tandem mass spectrometry (LC-MS/MS) [21], micellar electrokinetic chromatography [22], and ion-pair chromatography [23]. Belal et al (2014) have developed a high-performance thin-layer chromatography (HPTLC) method for the simultaneous determination of five drugs, namely, alfuzosin, terazosin, prazosin, doxazosin, and finasteride, prescribed for BPH.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a reversed-phase HPLC method for simultaneous determination of doxazosin mesylate and finasteride

Krotz

Mengesha

2017

Acta Chromatographica

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Summary.A reversed-phase high-performance liquid chromatographic (RP-HPLC) method was developed and validated for the simultaneous determination of doxazosin mesylate (DOX) and finasteride (FIN) in bulk powders and pharmaceutical formulations. The compounds were separated on a Pinnacle II C18 column (250 × 4.6 mm i.d.; particle size, 5 μm) with an isocratic mobile phase at a flow rate of 1.0 mL min −1 . The mobile phase was a mixture of 25 mM ammonium acetate and acetonitrile in the ratio of 50:50 %v/v. The pH of the buffer was adjusted to 4.0 ± 0.05 with glacial acetic acid. The detection was performed at 230 nm. The total chromatographic analysis time per sample was 15 min with DOX and FIN eluting at 3.9 and 7.2 min, respectively. The accuracy, precision, specificity, linearity, and sensitivity of the method were validated according to the International Conference on Harmonization (ICH) guidelines. The calibration plots were linear (r 2 > 0.999) over the concentration range 24.25-291.0 μg mL −1 and 122.5-1470.0 μg mL −1 for DOX and FIN, respectively. The method was used for the simultaneous determination of DOX and FIN in capsules.

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“…Various methods have been published for the determination of doxazosin mesylate either by itself or in pharmaceutical preparations and biological fluids. The methods included liquid chromatography [2][3][4][5] , high performance thin layer chromatography 6 , flow injection with UV detection 7 and polarography 8 . The only reported spectrophotometric methods were that either measuring doxazosin absorbance at 248 nm in methanol 9 , first derivative in presence of its degraded product 10 or reacting with bromocresol green and bromothymol blue and measuring the color after extraction the complex in chloroform 11 .…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric and Spectrofluorometric Determination of Doxazosin Mesylate in Tablets via Eosin Y

Ammar¹,

El-Brashy²,

Al-Sahly³

2014

Asian J. Chem.

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Doxazosin mesylate, an inhibitor of α-adrenergic receptors, was determined through formation of ion-pair complex with Eosin Y reagent in acetate buffer at pH 3. Two simple and sensitive spectroscopic methods were suggested. The first method based on spectrophotometric measurement of the complex at 547 nm and the second one based on spectrofluorimetric quenching measurement of the complex at 570 nm, after excitation at 340 nm. Under the optimum conditions, doxazosin mesylate was determined in the range of 2-14 µg mL-1 and 1-10 µg mL-1 by the spectrophotometric and spectrofluorimetric methods respectively, with good accuracy and precision in pure form. The method was successfully applied for determination of doxazosin mesylate in its tablets. All the results were statistically compared with that obtained by a reference method and subjected to validation analysis according to International Conference on Harmonization.

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Determination of doxazosin mesylate in tablets by RP-HPLC

Cited by 8 publications

References 13 publications

Pyridinium trifluoroacetate ionic liquids as proficient catalysts for synthesis of 3,5,5‐trimethyl‐2‐pyrazoline

Pyridinium trifluoroacetate ionic liquids as proficient catalysts for synthesis of 3,5,5‐trimethyl‐2‐pyrazoline

Development and validation of a reversed-phase HPLC method for simultaneous determination of doxazosin mesylate and finasteride

Spectrophotometric and Spectrofluorometric Determination of Doxazosin Mesylate in Tablets via Eosin Y

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