Determination of docetaxel in dried blood spots by LC–MS/MS: Method development, validation and clinical application

Raymundo, Suziane; Müller, Victória Vendramini; Andriguetti, Natália Bordin; Tegner, Mariane; Artmann, A.; Klück, Helena Moreira; Franzoi, Maria Alice; Vilela, Ramon Magalhães Mendonça; Schwartsmann, Gilberto; Linden, Rafael; Antunes, Marina Venzon

doi:10.1016/j.jpba.2018.05.011

Cited by 17 publications

(12 citation statements)

References 25 publications

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“…The other two approaches had better performance to predict EC pla from C DBS , as reported in following sections. Raymundo et al (39), described a LC-MS/MS method for the quantification of docetaxel in DBS from both finger-prick and venous blood. This method was applied for the quantification of this anticancer drug in 31 patients affected by different solid tumors and treated with docetaxel as monotherapy or in combination with other drugs.…”

Section: Normalization Based On Blood-to-plasma Partitioning and Hctmentioning

confidence: 99%

Dried Blood Spot Technique Applied in Therapeutic Drug Monitoring of Anticancer Drugs: a Review on Conversion Methods to Correlate Plasma and Dried Blood Spot Concentrations

et al. 2021

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Background Anticancer drugs are notoriously characterized by a low therapeutic index, the introduction of therapeutic drug monitoring (TDM) in oncologic clinical practice could therefore be fundamental to improve treatment efficacy. In this context, an attractive technique to overcome the conventional venous sampling limits and simplify TDM application is represented by dried blood spot (DBS). Despite the significant progress made in bioanalysis exploiting DBS, there is still the need to tackle some challenges that limit the application of this technology: one of the main issues is the comparison of drug concentrations obtained from DBS with those obtained from reference matrix (e.g., plasma). In fact, the use of DBS assays to estimate plasma concentrations is highly dependent on the chemical-physical characteristics of the measured analyte, in particular on how these properties determine the drug partition in whole blood. Methods In the present review, we introduce a critical investigation of the DBS-to-plasma concentration conversion methods proposed in the last ten years and applied to quantitative bioanalysis of anticancer drugs in DBS matrix. To prove the concordance between DBS and plasma concentration, the results of statistical tests applied and the presence or absence of trends or biases were also considered.

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Section: Normalization Based On Blood-to-plasma Partitioning and Hctmentioning

confidence: 99%

Dried Blood Spot Technique Applied in Therapeutic Drug Monitoring of Anticancer Drugs: a Review on Conversion Methods to Correlate Plasma and Dried Blood Spot Concentrations

et al. 2021

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“…In this review, DBS has been shown to be widely used in transplantation and haemato-oncology patients to monitor therapeutic ranges [27,40,[86][87][88][89][90][91][92]. DBS is also suitable for TDM of tacrolimus in paediatric transplant recipients [93].…”

Section: Dried Blood Spotsmentioning

confidence: 99%

“…Most studies included in this review (n = 44, 77%) discussed the haematocrit effect on measured drug concentrations, and some even used patient-specific haematocrit values for calculating theoretical blood levels [28,92,[95][96][97]. Recently, alternative DBS methods have been introduced to increase the extraction efficiency and to overcome problems associated with DBS samples [98].…”

Section: Dried Blood Spotsmentioning

confidence: 99%

Clinical Value of Emerging Bioanalytical Methods for Drug Measurements: A Scoping Review of Their Applicability for Medication Adherence and Therapeutic Drug Monitoring

Zijp

Izzah

Åberg

et al. 2021

Drugs

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“…Despite this, there is a growing interest in the application of DBS in oncology. DBS‐based methods have been described for the measurement of hormone therapy drugs, 42–44 antimetabolites, 45 alkylating agents, 46–49 taxanes, 50–53 vinca alkaloids 54 and topoisomerase inhibitors 55 . However, tyrosine kinase inhibitors are the class for which most DBS‐based studies have been published 56–63 .…”

Section: Sampling Strategiesmentioning

confidence: 99%

Barriers and opportunities for the clinical implementation of therapeutic drug monitoring in oncology

Menz

Stocker

Verougstraete

et al. 2020

Brit J Clinical Pharma

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There are few fields of medicine in which the individualisation of medicines is more important than in the area of oncology. Under‐dosing can have significant ramifications due to the potential for therapeutic failure and cancer progression; by contrast, over‐dosing may lead to severe treatment‐limiting side effects, such as agranulocytosis and neutropenia. Both circumstances lead to poor patient prognosis and contribute to the high mortality rates still seen in oncology. The concept of dose individualisation tailors dosing for each individual patient to ensure optimal drug exposure and best clinical outcomes. While the value of this strategy is well recognised, it has seen little translation to clinical application. However, it is important to recognise that the clinical setting of oncology is unlike that for which therapeutic drug monitoring (TDM) is currently the cornerstone of therapy (e.g. antimicrobials). Whilst there is much to learn from these established TDM settings, the challenges presented in the treatment of cancer must be considered to ensure the implementation of TDM in clinical practice. Recent advancements in a range of scientific disciplines have the capacity to address the current system limitations and significantly enhance the use of anticancer medicines to improve patient health. This review examines opportunities presented by these innovative scientific methodologies, specifically sampling strategies, bioanalytics and dosing decision support, to enable optimal practice and facilitate the clinical implementation of TDM in oncology.

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Determination of docetaxel in dried blood spots by LC–MS/MS: Method development, validation and clinical application

Cited by 17 publications

References 25 publications

Dried Blood Spot Technique Applied in Therapeutic Drug Monitoring of Anticancer Drugs: a Review on Conversion Methods to Correlate Plasma and Dried Blood Spot Concentrations

Dried Blood Spot Technique Applied in Therapeutic Drug Monitoring of Anticancer Drugs: a Review on Conversion Methods to Correlate Plasma and Dried Blood Spot Concentrations

Clinical Value of Emerging Bioanalytical Methods for Drug Measurements: A Scoping Review of Their Applicability for Medication Adherence and Therapeutic Drug Monitoring

Barriers and opportunities for the clinical implementation of therapeutic drug monitoring in oncology

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