Determination of diclofenac in plasma using a fully automated analytical system combining liquid—solid extraction with liquid chromatography

Sioufi, A.; Richard, John J.; Mangoni, Patrick; Godbillon, J.

doi:10.1016/0378-4347(91)80401-w

Cited by 15 publications

(1 citation statement)

References 8 publications

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“…The Limit Of Quantification (LOQ) was 0.8 pmol/l. Diclofenac was determined by an HPLC method with an LOQ of 32.4 nmol/l (Sioufi et al 1991) at the laboratories of CibaGeigy, Bioanalytics and Pharmacokinetics, France.…”

Section: Methodsmentioning

confidence: 99%

No Effect of Diclofenac on the Pharmacokinetics of Cloxacillin

Nergelius¹,

Vinge²,

Bengtsson³

et al. 1997

Pharmacology & Toxicology

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Abstract:We studied the influence of diclofenac on the pharmacokinetics of cloxacillin in healthy volunteers, 60 years or older, as well as the possible effect of cloxacillin and diclofenac on urinary protein excretion. In a randomized, doubleblind, cross-over study 15 subjects were given 1 g cloxacillin. and placebo or 75 mg diclofenac, as single intravenous doses. Plasma concentrations of cloxacillin were followed over 10.5 hr, and urine excretion of cloxacillin over 24 hr. The effect of the drugs on urinary excretion of protein indicators of glomerular (albumin, IgG) and tubular (protein HC) function was also studied. Total plasma clearance of cloxacillin was with placebo 219251 (mean +S.D.), and with diclofenac 212k39 ml/min./1.73 m2 (ns); renal clearance was 97221 and 96524 mVmin.il.73 m2, respectively (ns). The terminal tjj2 of cloxacillin was 1.03+0.42 hr with placebo, and 1.1220.37 with diclofenac (ns). The mean ratio of AUC,L,'s (cloxacillin plus diclofenac/cloxacillin plus placebo) was 1.03 (90% CI: 0.99, 1.08). Urinary excretion of the proteins was low and was not increased by cloxacillin or diclofenac. In healthy volunteers, 60 years or older, diclofenac does not alter cloxacillin pharmacokinefcs, and neither cloxacillin nor diclofenac in single intravenous doses cause renal dysfunction.

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Section: Methodsmentioning

confidence: 99%