Determination of Diammonium Glycyrrhizinate and Its Antioxidant Activity Using a Novel Chemiluminescence System

Zhuo, Chen; Zhang, Xian; Qiu, Xia-Lin; He, Xiaoliang; Lu, Dengfeng

doi:10.1080/00032719.2012.680055

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…Eosin Y, a xanthene fluorescent dye, has been used as a chemiluminescence reagent in CL analysis . In this study, it was found that a strong PCL signal was given out when a trace amount of lercanidipine was injected into the reaction mixture of N ‐chlorosuccinimide and eosin Y solution, and the PCL signal was strongly dependent on the lercanidipine concentration when cetyltrimethylammonium bromide (CTAB) is present.…”

Section: Introductionmentioning

confidence: 99%

Flow injection chemiluminescence determination of lercanidipine based on N‐chlorosuccinimide–eosin Y post‐chemiluminescence reaction

2014

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A novel post-chemiluminescence (PCL) reaction was discovered when lercanidipine was injected into the CL reaction mixture of N-chlorosuccinimide with alkaline eosin Y in the presence of cetyltrimethylammonium bromide (CTAB), where eosin Y was used as the CL reagent and CTAB as the surfactant. Based on this observation, a simple and highly sensitive PCL method combined with a flow injection (FI) technique was developed for the assay of lercanidipine. Under optimum conditions, the CL signal was linearly related to the concentration of lercanidipine in the range 7.0 × 10(-10) to 3.0 × 10(-6) g/mL with a detection limit of 2.3 × 10(-10) g/mL (3σ). The relative standard deviation (RSD) was 2.1% for 1.0 × 10(-8) g/mL lercanidipine (n = 13). The proposed method had been applied to the estimation of lercanidipine in tablets and human serum samples with satisfactory results. The possible CL mechanism is also discussed briefly.

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Section: Introductionmentioning

confidence: 99%

Flow injection chemiluminescence determination of lercanidipine based on N‐chlorosuccinimide–eosin Y post‐chemiluminescence reaction

2014

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“… 2 Hence, malondialdehyde (MDA) assay or chemiluminescence methods for DG antioxidant activity measurement should be performed. 3 Moreover, other modalities such as stem cells, cell secretomes, or neurotrophic factor–mediated neuroprotection in IR injury are worth revisiting and brought to in-depth discussion. 4 , 5 Finally, how the authors extrapolate the optimal DG dose at 20 mg/kg/day to humans requires further explanation since the results of this study are very promising and applicable in clinical settings.…”

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confidence: 99%

Effect of Diammonium Glycyrrhizinate in Improving Focal Cerebral Ischemia-Reperfusion Injury in Rats Through Multiple Mechanisms

Dany,

Intan,

Noviantari

2024

Dose-Response

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Dear Editor,We are interested in reviewing an article by Wang H et al 1 entitled "Effect of Diammonium Glycyrrhizinate in Improving Focal Cerebral Ischemia-Reperfusion Injury in Rats through Multiple Mechanisms" recently published in the Dose-Response journal. We would like to address our concerns notably on methods implemented in this study.Whether the researchers performed pre-conditioned training in rats prior to implementing the Zea-Longa protocol should be described in detail. Since ischemia-reperfusion (IR) injury is associated with oxidative stress particularly during reperfusion, the neuroprotective effects of diammonium glycyrrhizinate (DG) might be partly due to its antioxidant properties. 2 Hence, malondialdehyde (MDA) assay or chemiluminescence methods for DG antioxidant activity measurement should be performed. 3 Moreover, other modalities such as stem cells, cell secretomes, or neurotrophic factor-mediated neuroprotection in IR injury are worth revisiting and brought to in-depth discussion. 4,5 Finally, how the authors extrapolate the optimal DG dose at 20 mg/kg/day to humans requires further explanation since the results of this study are very promising and applicable in clinical settings. Given several perspectives described above, some improvements can be made to optimize the findings of this study in further research.

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Potassium Periodate–Luminol–Silver Nanoparticles as a New Chemiluminescence System and its Application to Detect Fenoterol and Orciprenaline

Wang

et al. 2014

Analytical Letters

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Determination of Diammonium Glycyrrhizinate and Its Antioxidant Activity Using a Novel Chemiluminescence System

Cited by 4 publications

References 8 publications

Flow injection chemiluminescence determination of lercanidipine based on N‐chlorosuccinimide–eosin Y post‐chemiluminescence reaction

Flow injection chemiluminescence determination of lercanidipine based on N‐chlorosuccinimide–eosin Y post‐chemiluminescence reaction

Effect of Diammonium Glycyrrhizinate in Improving Focal Cerebral Ischemia-Reperfusion Injury in Rats Through Multiple Mechanisms

Potassium Periodate–Luminol–Silver Nanoparticles as a New Chemiluminescence System and its Application to Detect Fenoterol and Orciprenaline

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