Determination of dexamethasone and two excipients (creatinine and propylparaben) in injections by using UV-spectroscopy and multivariate calibrations

Collado, María S.; Robles, Juan C.; Zan, Mercedes De; Cámara, Marı́a S.; Mantovani, Víctor E.; Goicoechea, Héctor C.

doi:10.1016/s0378-5173(01)00866-3

Cited by 18 publications

(4 citation statements)

References 15 publications

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“…The applicability of this film to nanoparticle transition for controlled drug release was evaluated using dexamethasone, a poorly water-soluble, anti-inflammatory and immuno-suppressive drug [24,25]. To load the nanoparticles with dexamethasone, the drug was co-dissolved with the mPEG 3 -PTMC 11 copolymer during the film preparation step.…”

Section: Resultsmentioning

confidence: 99%

Thermo-sensitive transition of monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate) films to micellar-like nanoparticles

Zhang

Grijpma

Feijén

2006

Journal of Controlled Release

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Section: Resultsmentioning

confidence: 99%

Thermo-sensitive transition of monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate) films to micellar-like nanoparticles

Zhang

Grijpma

Feijén

2006

Journal of Controlled Release

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“…The particle size, polydispersity index (PDI) and ζ-potential values of plain and drug-loaded samples were measured in gastric fluids, in triplicates. On surveying the literature, there are numerous analytical approaches to determine DSP in various samples of biological, animal-derived foodstuffs, etc., in which liquid chromatography (LC), coupled with spectrophotometric (UV) [8] or mass spectrometric detection (MS), is the predominant analytical technique [9][10][11]. Concerning the sample preparation, several efforts have been made to isolate DSP from complicated matrices involving solid phase extraction [12,13], matrix solid phase dispersion [9,14], liquid phase microextraction (LPME) [15], QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) [16,17] and simple protein precipitation [18].…”

Section: Dynamic Light Scattering and ζ-Potential Studiesmentioning

confidence: 99%

Solid Dosage Forms of Dexamethasone Sodium Phosphate Intended for Pediatric Use: Formulation and Stability Studies

et al. 2020

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Undesirable taste has always been a key issue for oral dosage forms. The aim of the present study was to co-formulate dexamethasone sodium phosphate (DSP), in common pediatric oral forms, using sweet preserves and/or different types of chocolate as excipients. An array of different kinds of chocolate were co-formulated with DSP and were further characterized by means of dynamic light scattering (DLS), x-ray diffraction (XRD), differential scanning calorimetry (DSC) and Fourier-transform infrared (FT-IR) spectroscopy. For the assay of active pharmaceutical ingredient (API), the chocolate samples were pre-treated by means of liquid extraction and analyzed using an high-performance liquid chromatographic (HPLC) method with a strong anion exchange column and a phosphate buffer (17 mM, pH = 3)/acetonitrile, 50:50 v/v as mobile phase. The developed chromatographic method was validated based on the International Conference on Harmonization (ICH) guidelines (%Mean Recovery = 99.4% and %Relative Standard Deviation, RSD = 0.43%). Furthermore, dissolution and in vitro digestion tests of chocolate formulations were evaluated. The DSP was found to be stable for at least 1 year in prepared preparations.

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“…By reviewing literature, several methods reported were reported for the determination of OFX, such as titrimetry [3], spectrophotometry [4, 5], and chromatography [6, 7]. For DXM, reported methods were found, such as spectrophotometry [8, 9], micellar liquid chromatography [10], HPLC [11, 12], and capillary electrophoresis [13]. Simultaneous determination of ofloxacin and dexamethasone phosphate has been reported in the literature by spectrophotometric methods [14, 15] and chromatographic methods [16, 17].…”

Section: Introductionmentioning

confidence: 99%

Investigating Advanced Approaches Based on Iso-Absorptivity Coefficient in Unresolved Spectral Signals of Binary Mixtures

Lotfy

Saleh

2019

Journal of Analytical Methods in Chemistry

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Several spectrophotometric approaches utilize different functions of the iso-absorptivity coefficient in zero-order absorption signals and its manipulated spectra. This work introduced an investigation concerning the efficiency power of recent methods based on iso-absorptivity coefficient in different spectral signals. These methods were as follows: absorptivity centering method (a-Centering), absorbance subtraction method (AS), amplitude modulation method (AM,) and amplitude summation method (A-Sum). These methods were applied to determine the binary mixture of ofloxacin (OFX) and dexamethasone (DXM). Linearity of the proposed methods was investigated in the range of 1.0–10.0 μg/ml for both drugs. The proposed methods were validated as per ICH guidelines and were successfully applied for the simultaneous determination of OFX and DXM in their pharmaceutical preparation without interference from additives. Statistical analysis of the results obtained by the proposed spectrophotometric methods compared with a reported method revealed no significant difference between the proposed and reported methods, confirming accuracy and precision at 95% confidence limit.

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Determination of dexamethasone and two excipients (creatinine and propylparaben) in injections by using UV-spectroscopy and multivariate calibrations

Cited by 18 publications

References 15 publications

Thermo-sensitive transition of monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate) films to micellar-like nanoparticles

Thermo-sensitive transition of monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate) films to micellar-like nanoparticles

Solid Dosage Forms of Dexamethasone Sodium Phosphate Intended for Pediatric Use: Formulation and Stability Studies

Investigating Advanced Approaches Based on Iso-Absorptivity Coefficient in Unresolved Spectral Signals of Binary Mixtures

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