Determination of dapoxetine in rat plasma by ultra-performance liquid chromatography–tandem mass spectrometry

Kim, Tae Kon; Kim, In Sook; Hong, Seok Hyun; Choi, Yun Kyoung; Kim, Ho-Hyun; Yoo, Hye Hyun

doi:10.1016/j.jchromb.2013.03.002

Cited by 13 publications

(8 citation statements)

References 11 publications

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“…The maximum serum concentration is reached approximately 0.3-1.15 h and 1-2 h and aer the oral administration of Ava-nal and Dapoxetine; respectively. [21][22][23][24][25][26][27][28] Hence, the validated bioanalytical method was efficiently applied to analyze Avanal and Dapoxetine in human plasma from real subjects 2 h following the oral administration of (Avanal/Dapoxetine tablets; 200/60 mg) showing (average concentrations AE % RSD) of (3000/250 ng mL À1 AE 5%), for Avanal and Dapoxetine; respectively.…”

Section: Applicationmentioning

confidence: 99%

“…17 Various chromatographic methods were also applied for determination of the cited mixture such as HPTLC 4 and HPLC with different detectors as UV, uorescence detection 1,8,9,12,16,[18][19][20] and with tandem mass spectrometry. [21][22][23][24][25][26][27][28] A brief comparison between the different LC-MS/MS methods from the previously reported in the literature and the developed one is elucidated in Table 1.…”

Section: Introductionmentioning

confidence: 99%

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Simultaneous determination of Avanafil and Dapoxetine in human plasma using liquid chromatography/tandem mass spectrometry (LC-MS/MS) based on a protein precipitation technique

et al. 2021

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Section: Applicationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of Avanafil and Dapoxetine in human plasma using liquid chromatography/tandem mass spectrometry (LC-MS/MS) based on a protein precipitation technique

et al. 2021

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“…Literature review: DPX is a newly developed SSRI drug. Some papers were reported for its determination alone in pharmaceutical dosage forms and in biological fluids [51][52][53]. However, being the first approved drug for on-demand treatment of PE, its determination with other drugs that are used for treatment of ED was reported.…”

Section: Hclmentioning

confidence: 99%

Erectile Dysfunction and Premature Ejaculation Drugs: Mode of Action and Analytical Methods Literature Review

Ae¹,

Elhenawee²,

Saleh³

et al. 2021

J Drug Res Dev

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“… 31 Ultraperformance liquid chromatography-MS/MS has also been reported for the quantification of DPX in biological fluids. 5 , 32 Obviously, all these reported instrumental techniques are costly and demand professional training; analytically useful alternatives are sought after.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Determination of the Serotonin Reuptake Inhibitor, Dapoxetine, Using Cesium–Gold Nanoparticles

et al. 2017

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Cesium–gold (Cs–Au) nanoparticles are shown to be analytically advantageous for the electroanalytical sensing of dapoxetine (DPX), a serotonin reuptake inhibitor used for the treatment of premature ejaculation. The Cs–Au nanoparticles are electrically wired and supported upon mass producible, economical screen-printed electrochemical sensing platforms and are characterized electrochemically (cyclic voltammetry and electrochemical impedance spectroscopy) and physiochemically (field emission scanning electron microscopy and energy dispersive X-ray analysis). The face-centered design was applied to optimize the significant experimental factors by using square wave voltammetry. The Cs–Au-based sensor is found to exhibit a large linear range (10–7 to 10–4 M) with a good analytical linearity with the limits of detection and quantification corresponding to 2.50 × 10–10 and 8.33 × 10–8 M, respectively. The developed sensor was successfully applied in the quantification of DPX in the presence of sildenafil, both of which are commonly found within combined dose tablet pharmaceutical formulations. The proposed DPX electrochemical Cs–Au-based sensor has the advantages of being single-shot and disposable and is shown to be successful in determining DPX in pharmaceutical formulations, human urine, and serum samples with acceptable recoveries.

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Determination of dapoxetine in rat plasma by ultra-performance liquid chromatography–tandem mass spectrometry

Cited by 13 publications

References 11 publications

Simultaneous determination of Avanafil and Dapoxetine in human plasma using liquid chromatography/tandem mass spectrometry (LC-MS/MS) based on a protein precipitation technique

Simultaneous determination of Avanafil and Dapoxetine in human plasma using liquid chromatography/tandem mass spectrometry (LC-MS/MS) based on a protein precipitation technique

Erectile Dysfunction and Premature Ejaculation Drugs: Mode of Action and Analytical Methods Literature Review

Electrochemical Determination of the Serotonin Reuptake Inhibitor, Dapoxetine, Using Cesium–Gold Nanoparticles

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