Determination of curcumin by its quenching effect on the fluorescence of Eu3+–tryptophan complex

Wang, Feng; Huang, Wei

doi:10.1016/j.jpba.2006.07.007

Cited by 26 publications

(8 citation statements)

References 16 publications

(13 reference statements)

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“…From the UV-vis spectra shown in Fig. That is to say, the decreased fluorescence intensity of Zn(II)-bix and the enhanced fluorescence intensity of FUR should be ascribed to the formation of ternary complexes of Zn(II)-bix-FUR (23). With the addition of increased Zn(II)-bix into the FUR solution, the original absorption of FUR at 228 and 276 nm becomes weakened, whereas the peak at 330 nm is enhanced slightly.…”

Section: Resultsmentioning

confidence: 89%

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A simple and sensitive spectrofluorimetric method for the determination of furosemide using zinc(II)–1,4‐bis(imidazol‐1‐ylmethyl)benzene complexes

Liu

Wang

et al. 2012

Luminescence

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A novel spectrofluorometric method for the determination of furosemide (FUR) is described. The method is based on enhancement of fluorescence emission of FUR in the presence of zinc (II) complexes of 1,4-bis(imidazol-1-ylmethyl)benzene. Under optimum conditions, the enhanced fluorescence intensity is linearly related to the concentration of FUR. The proposed method has been successfully applied to the determination of FUR in pharmaceutical preparations. The possible mechanism of this reaction is discussed briefly based on data from fluorescence spectroscopy, UV-vis absorption and infrared spectroscopy.

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Section: Resultsmentioning

confidence: 89%

“…These results confirmed that some ternary complex has formed (the structure of this ternary complex is shown in Scheme 1). That is to say, the decreased fluorescence intensity of Zn(II)-bix and the enhanced fluorescence intensity of FUR should be ascribed to the formation of ternary complexes of Zn(II)-bix-FUR (23).…”

Section: Resultsmentioning

confidence: 98%

A simple and sensitive spectrofluorimetric method for the determination of furosemide using zinc(II)–1,4‐bis(imidazol‐1‐ylmethyl)benzene complexes

Liu

Wang

et al. 2012

Luminescence

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“…Fluorimetric methods have shown to be sensitive, simple, rapid and reproducible for the quantitative determination of many compounds (Aktas et al, 2003;Abdellatef et al, 2006). Considering the biological interest of curcumin, several studies have previously reported the determination of this drug by fluorimetric methods (Wang et al, 2006;Wang, Huang, 2007;Wang et al, 2008). However, the steady-state absorption and fluorescence characteristics of curcumin have been found to be sensitive to the solvent's characteristics.…”

Section: Resultsmentioning

confidence: 99%

Development and validation of a fluorimetric method to determine curcumin in lipid and polymeric nanocapsule suspensions

Mazzarino

Bellettini

Minatti

et al. 2010

Braz. J. Pharm. Sci.

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A simple, rapid, and sensitive fluorimetric method was developed and validated to quantify curcumin in lipid and polymeric nanocapsule suspensions, using acetonitrile as a solvent. The excitation and emission wavelengths were set at 397 nm and 508 nm, respectively. The calibration graph was linear from 0.1 to 0.6 mg/mL with a correlation coefficient of 0.9982. The detection and quantitation limits were 0.03 and 0.10 mg/mL, respectively. The validation results confirmed that the developed method is specific, linear, accurate, and precise for its intended use. The current method was successfully applied to the evaluation of curcumin content in lipid and polymeric nanocapsule suspensions during the early stage of formulation development.Uniterms: Curcumin/determination. Fluorimetric method/quantitative analysis. Polymeric nanocapsules/ evaluation. Lipid nanocapsules/evaluation.Um método fluorimétrico simples, rápido e sensível foi desenvolvido e validado para quantificação da curcumina em suspensões de nanocápsulas lipídicas e poliméricas, usando acetonitrila como solvente. Os comprimentos de onda de excitação e emissão foram 397 nm e 508 nm, respectivamente. Nas condições testadas, a curva de calibração demonstrou-se linear na faixa de 0,1 a 0,6 mg/mL, exibindo coeficiente de correlação de 0,9982. Os limites de detecção e quantificação foram 0,03 e 0,10 mg/mL, respectivamente. Os resultados da validação confirmaram que o método desenvolvido é específico, linear, exato e preciso para o uso proposto. O presente método foi aplicado com sucesso para a avaliação do teor de curcumina nas suspensões de nanocápsulas lipídicas e poliméricas durante o estágio inicial do desenvolvimento da formulação.Unitermos: Curcumina/determinação. Método fluorimétrico/análise quantitativa. Nanocápsulas poliméricas/avaliação. Nanocápsulas lipídicas/avaliação.

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“…Wang et al (2007) established a fluorescence analysis method to determine curcumin, based on the quenching effect of curcumin to the fluorescence of Eu 3+ -tryptophan complex [64]. It was found that curcumin significantly quenched the fluorescence intensity in the buffer of pH 7.7, and the quench intensity is in proportion to the concentration of curcumin at the range of 1.0×10 -8 to 1.2×10 -4 mol L -1 .…”

Section: Spectroscopymentioning

confidence: 99%

Chemical Analysis of the Chinese Herbal Medicine Turmeric (Curcuma longa L.)

Li¹,

Xiang²,

Xing³

et al. 2010

CPA

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Turmeric (Curcuma longa L., Zingiberaceae family) is a well known Chinese herbal medicine. It possesses diverse pharmacologic effects including antioxidant, anti-inflammatory, antiproliferative and antiangiogenic activities. The main bioactive constituents of C. longa include sesquiterpenes, which are responsible for its aroma, and curcuminoids, which contribute to its bright yellow color. Both sesquiterpenes and curcuminoids exhibit great potential as therapeutic agents for various diseases including colon cancer, pancreatic cancer, diabetes and Alzheimer's disease. Particularly, curcumin, one of the major curcuminoids of turmeric, has been proved to be effective in cancer treatment and prevention by recent phase I clinical trials. In order to ensure the efficacy and safety of turmeric in clinical applications, sensitive and accurate analytical methods are of significance for the comprehensive quality control of C. longa. This review summarizes recent progress in the chemical analysis of sesquiterpenes and curcuminoids in turmeric.

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Determination of curcumin by its quenching effect on the fluorescence of Eu3+–tryptophan complex

Cited by 26 publications

References 16 publications

A simple and sensitive spectrofluorimetric method for the determination of furosemide using zinc(II)–1,4‐bis(imidazol‐1‐ylmethyl)benzene complexes

A simple and sensitive spectrofluorimetric method for the determination of furosemide using zinc(II)–1,4‐bis(imidazol‐1‐ylmethyl)benzene complexes

Development and validation of a fluorimetric method to determine curcumin in lipid and polymeric nanocapsule suspensions

Chemical Analysis of the Chinese Herbal Medicine Turmeric (Curcuma longa L.)

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