Determination of cicletanine enantiomers in plasma by high-performance capillary electrophoresis

Pruñonosa, J; Obach, R.; Diez-Cascón, Angel; Gouesclou, Laurent

doi:10.1016/0378-4347(92)80106-z

Cited by 79 publications

(9 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ability of CD to effect chiral separation is well-established (Ueda et al, 1991(Ueda et al, , 1992Terabe et al, 1985Terabe et al, , 1990; Nishi e t a f . , 1991; Prunonosa et al, 1992;Kuhn and Kuhn, 1992;Fanali, 1991). The pertinent equilibrium reactions, in addition to reactions 1 and 2, are K7 K , Figure 2 shows the individual CD-MEKC electropherograms for the separation of five different dipeptides with only one chiral centre.…”

Section: Resultsmentioning

confidence: 93%

Chiral separation of naphthalene‐2, 3‐dialdehyde labelled peptides by cyclodextrin‐modified electrokinetic chromatography

DeSilva¹,

Jiang²,

Kuwana³

1995

Biomedical Chromatography

View full text Add to dashboard Cite

The chiral separation of several dipeptide enantiomers, derivatized by naphthalene-2,3-dialdehyde (NDA), was achieved by use of cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC). The dipeptides contained one or two chiral centers. In the case of several dipeptides containing two chiral centers, all four of the optical isomers could be separated and baseline resolved in less than 15 min with 20 mM gamma-CD and 50 mM sodium dodecyl sulphate (SDS) in the background electrolyte. The order of elution of these derivatized dipeptides was explained by considering important chemical equilibria in the SDS, CD and peptide system. Additionally, the influence of geometric location of the chiral center, the structure of the side-chain and the effect of CD concentration on the resolution are discussed.

show abstract

Section: Resultsmentioning

confidence: 93%

Chiral separation of naphthalene‐2, 3‐dialdehyde labelled peptides by cyclodextrin‐modified electrokinetic chromatography

DeSilva¹,

Jiang²,

Kuwana³

1995

Biomedical Chromatography

View full text Add to dashboard Cite

show abstract

“…Enantiomers moved towards the detector transported by the EOF and SDS and CDs were the selective agents. After this publication several groups applied the so‐called CD‐MEKC method to the analysis of uncharged molecules in biological samples where the presence of SDS was also useful to solubilize compounds interfering with the analytical separation 41–43. Recently, this approach gave interesting results for practical applications combining SDS and β‐CD, e.g .…”

Section: Short Historical Overview Of Fundamental Research In Chiramentioning

confidence: 99%

Chiral separations by CE employing CDs

Fanali¹

2009

Electrophoresis

120

View full text Add to dashboard Cite

This paper summarizes the history of chiral separations done by using electromigration methods with CDs. Several enantioresolution mechanisms and a wide number of chiral selectors have been applied to the separation of optical isomers by CE. Among them inclusion-complexation with CDs or their derivatives played a very important role in CE. Since the beginning our group was involved in studying method optimization for enantiomer resolution by using these chiral selectors. One of our publications was the basis for further development in the field, at least for us. New chiral selectors, development of theory, new methodological approaches and a wide number of practical applications are the main results achieved in the last almost 25 years using CE as an enantioseparative technique.

show abstract

“…The MEKC method was employed in chiral separations of various compounds: amino acid derivatives, 194 ± 197 aromatase and barbiturate inhibitors, 165 b-blockers, 198 triazole derivatives, 199,200 dihydropyridine derivatives, 201 cicletanine, 202 mephenytoin, phenytoin and their 4-hydroxy derivatives, 203 peptide derivatives, 204,205 pesticides, 206 etc. In CD-MEKC, bile acids belonging to chiral surfactants and their salts are also used for separating enantiomers of dansyl amino acids, 207 ± 209 baclofen and its analogues, mephenytoin and fenoldopam and their derivatives, 207 amino acid derivatives, such as N-substituted 1-cyanobenzo[ f ]isoindoles (CBI amino acids), 208 OPA amino acids, 210 phenylethylamines (diclofensine, ephedrine, methamphetamine, b-blockers) 211 and binaphthyl derivatives.…”

Section: Micellar Electrokinetic Chromatographymentioning

confidence: 99%