Determination of Chloride Ion in Formamide Solutions

Berger, Carl; Dawson, Lyle R.

doi:10.1021/ac60066a022

Cited by 12 publications

(12 citation statements)

References 3 publications

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“…The NMA (400 mL) was allowed to freeze at 28 °C overnight, and the liquid phase was considered impure following Berger and Dawson. 74 Fractional freezing was repeated three additional times, increasing the freezing temperature each time to ensure that more impurities were removed. A final melting point of 30.2 °C was achieved for the purified NMA, which would indicate a purity of >99.8%.…”

Section: Methodsmentioning

confidence: 99%

A Combined Experimental and Theoretical Study of Ion Solvation in Liquid N-Methylacetamide

Mazzanti

Whitfield

et al. 2010

J. Am. Chem. Soc.

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Most current biomolecular simulations are based on potential energy functions that treat the electrostatic energy as a sum of pairwise Coulombic interactions between effective fixed atomic charges. This approximation, in which many-body induced polarization effects are included in an average way, is expected to be satisfactory for a wide range of systems, but less accurate for processes involving the transfer and partition of ions among heterogeneous environments. The limitations of these potential energy functions are perhaps most obvious in studies of ion permeation through membrane channels. In many cases, the pore is so narrow that the permeating ion must shed most of its surrounding water molecules and the large energetic loss due to dehydration must be compensated by coordination with protein atoms. Interactions of cations with protein backbone carbonyl oxygens, in particular, play a critical role in several important biological channels. As a first step toward meeting the challenge of developing an accurate explicit accounting for induced polarization effects, the present work combines experiments and computation to characterize the interactions of alkali and halide ions with N-methylacetamide chosen to represent the peptide bond. From solubility measurements, we extract the solvation free energies of KCl and NaCl in liquid N-methylacetamide. Polarizable models based on the Drude oscillator are then developed and compared with available experimental and ab initio data. The good agreement for a range of structural and thermodynamic properties in the gas and condensed phases suggests that the polarizable models provide an accurate representation of ion–amide interactions in biological systems.

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Section: Methodsmentioning

confidence: 99%

A Combined Experimental and Theoretical Study of Ion Solvation in Liquid N-Methylacetamide

Mazzanti

Whitfield

et al. 2010

J. Am. Chem. Soc.

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“…g= [(e-e")(2t + e")9Mk7]/[t(c" + 2)2 X 4 µ02] (3) makes possible a description of polar liquids having specific short-range forces which hinder orientation of a molecule with respect to its surrounding neighbors. The significance of the calculated g value is that it gives an indication of the type of dipole-dipole alignment taking place.…”

Section: Resultsmentioning

confidence: 99%

“…This study was undertaken to determine the dielectric constants, viscosities, and other physical properties of five monosubstituted pyridines as functions of temperature. Experimental 2-Cyanopyridine (2CNP), 3-cyanopyridine (3CNP), 4cyanopyridíne (4CNP), 2-bromopyridine (2BrP), and 2chloropyridine (2CIP) were obtained from the Aldrich Chemical Co. The pyridines were vacuum distilled two or more times.…”

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Dielectric constants, viscosities, and related physical properties of five cyano- and halopyridines at several temperatures

Casteel¹,

Sears²

1975

J. Chem. Eng. Data

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“…mol −1 , respectively. Based on the Mohr Method (Berger and Dawson 1952), the presence or absence of chloride (counter) ions can be determined. In addition, the presence of white precipitate of Au(III) metal complex indicates an electrolytic nature (1:1) electrolyte of the complex, and the chloride ion is outside the coordination sphere.…”

Section: Molar Conductivitymentioning

confidence: 99%

Synthesis, spectral characterization and biological activities of Ag(I), Pt(IV) and Au(III) complexes with novel azo dye ligand (N, N, O) derived from 2-amino-6-methoxy benzothiazole

Kyhoiesh¹,

Al-Adilee

2022

Chem. Pap.

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The novel ligand 2-[2 ' -(6-methoxybenzothiazolyl)azo]-3,5-dimethyl benzoic acid (6-MBTAMB), derived from 2-amino-6-methoxy benzothiazole, has been used to synthesize a series of new metal complexes of Ag(I), Pt(IV) and Au(III). The metal complexes were characterized by elemental analyses (CHNS), molar conductivity, crystal structure (XRD), spectroscopic techniques: FT-IR, 1 H NMR, 13 C NMR, UV-Vis, mass spectra, thermal analysis (TG-DTA), FE-SEM and magnetic properties. Results con rmed that the azo dye ligand behaves a tridentate and coordinates to the metal ion via nitrogen atom of azomethine group of heterocyclic benzothiazole ring, nitrogen atom of the azo group which is the farthest of the benzothiazole molecule and carboxylic oxygen. Antimicrobial properties of all newly synthesized azo compounds are also demonstrated against bacterial pathogenic organisms and fungi. These complexes are more effective against bacteria and less effective against fungi compared to standard antibacterial drugs (Novobiocin) and antifungal drugs (Cycloheximide). By using the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging test, it was discovered that the complexes had good antioxidant properties. In addition, the (6-MBTAMB) and metal complexes were docked with the crystal structure of FGF Receptor 2 (FGFR2) kinase domain harboring the pathogenic gain of function K659E mutation identi ed in endometrial cancer using the Molecular Operating Environment module (MOE). In vitro studies on human endometrial cancer cell lines (MFE-296) as well as healthy human umbilical vein endothelial cells (HUVEC) show uptake of the intact compounds by the cancer cells and increased activity against the cancer cells. HighlightDiazo-coupling was used to synthesize the heterocyclic azo dye ligand (6-MBTAMB).Newly synthesized azo compounds have been con rmed by various spectroscopic techniques.Antimicrobial, antioxidant, anticancer, and molecular docking were used to evaluate 6-MBTAMB with metal complexes. MFE-296 cells were more responsive to 6-MBTAMB and Au(III)-Complex Cytotoxicity with IC 50 of 6-MBTAMB is 100.4 µg/ml and Au(III) metal complex is 43.44 µg/ml in MFE-296 cell line.

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Determination of Chloride Ion in Formamide Solutions

Cited by 12 publications

References 3 publications

A Combined Experimental and Theoretical Study of Ion Solvation in Liquid N-Methylacetamide

A Combined Experimental and Theoretical Study of Ion Solvation in Liquid N-Methylacetamide

Dielectric constants, viscosities, and related physical properties of five cyano- and halopyridines at several temperatures

Synthesis, spectral characterization and biological activities of Ag(I), Pt(IV) and Au(III) complexes with novel azo dye ligand (N, N, O) derived from 2-amino-6-methoxy benzothiazole

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