Determination of chloramphenicol residues in shrimps by liquid chromatography–mass spectrometry

Ramos, María Jesús; Muñóz, Patricia; Aranda, Angela; Rodríguez, Inés; Díaz, Raquel; Blanca, J.

doi:10.1016/s1570-0232(03)00186-7

Cited by 76 publications

(26 citation statements)

References 7 publications

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“…1,6 No maximum residue limit (MRL) of chloramphenicol in animalderived food has been established, because its toxic effects are not dose-dependent, but rather related to the hypersensitivity of certain individuals. 7 Several analytical methods have been reported for the determination of chloramphenicol in various samples, such as shrimp, 3,[8][9][10][11] seafood, meat, 7,12-15 eggs, 13 milk, 4,13 honey, 12,13,15 animal feeds, 5 urine, serum [14][15][16] and pharmaceutical formulations [17][18][19][20][21][22] based on liquid chromatography (LC), 5,12 liquid chromatography-mass spectrometry (LC-MS), 3,[7][8][9][10][11]14,15 gas chromatography (GC), gas chromatography-mass spectrometry (GC-MS), 3,12,14 capillary zone electrophoresis, 16,17 enzyme-linked immunosorbent assay (ELISA), 3,13 spectrophotometry, 18,19 and chemiluminescence. [20][21]…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Analysis of Chloramphenicol Using Boron-doped Diamond Electrode Applied to a Flow-Injection System

2008

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Section: Introductionmentioning

confidence: 99%

Electrochemical Analysis of Chloramphenicol Using Boron-doped Diamond Electrode Applied to a Flow-Injection System

2008

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“…Existing analytical methods for the determination of CAP include immunoassays (IAs) [2][3][4], microbiological methods [5], sensors [6], GC [7,8], LC-UV or LC-MS/MS [9][10][11][12], and CE [13][14][15]. Among these, IA and chromatographic assays (as LC-MS/MS) are widely used, although they have some drawbacks.…”

Section: Introductionmentioning

confidence: 99%

Competitive immunoassay by capillary electrophoresis with laser‐induced fluorescence for the trace detection of chloramphenicol in animal‐derived foods

et al. 2008

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A competitive immunoassay using CE with an LIF detector was developed for the detection of chloramphenicol (CAP). The method was based on the competitive reactions between fluorescently labeled CAP hapten and free CAP, with a limited amount of anti-CAP antibody. The poly(N-isopropylacrylamide) (pNIPA) hydrogel was added in the separation buffer as a dynamic modifier to reduce adsorption and enhance reproducibility. The linear range and LOD for CAP were 0.008-5 microg/L and 0.0016 microg/L, respectively. An ELISA using the same immuno-reagents was also developed for the analysis of CAP, with an LOD of 0.03 microg/L. The sensitivity of this CE immunoassay (CEIA)-LIF was almost 20 times greater than that of the ELISA. Using CEIA-LIF, equilibrium was reached in 15 min and the analytical results were obtained within 5 min by CE separation. Sample preparation for CEIA-LIF was not time-consuming and the matrix effect was easy to remove. An LOD of 0.1 microg/kg CAP in food matrices was easily achieved. This method is thus proposed as a fast and sensitive means of detecting trace amounts of CAP residues in animal-derived foods.

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“…The chromatographic method development for the estimation of Meloxicam and Dexlansoprazole were optimized by several trials for various parameters as different column, flow rate and mobile phase, finally the following chromatographic method was selected for the quantification of Meloxicam and Dexlansoprazole by RP-HPLC [14][15][16].…”

Section: Resultsmentioning

confidence: 99%

Method Development and Validation for Simultaneous Estimation of Dexlansoprazole and Meloxicam by Rp-Hplc

M¹

2015

Pharm Anal Acta

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To develop a method for simultaneous estimation of Dexlansoprazole and Meloxicam by RP-HPLC and validate the developed method according to ICH guidelines. The column used for method development of Dexlansoprazole and Meloxicam was Hypersil-BDS, C18, 250*4.6 mm, 5µ. Methanol and Acetonitrile were used in the ration of 60:40 for the method development. The developed method was validated for various parameters such as specificity, linearity, range, accuracy, precision, system suitability, robustness, ruggedness etc. The method was developed and optimized method was chosen and validated and the results were tabulated according to ICH guidelines. The result obtained in this study demonstrated that the HPLC method described is specific, accurate, precise, linear, ruggedness, robustness and stability indicating for the simultaneous determination of Dexlansoprazole and Meloxicam.

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Determination of chloramphenicol residues in shrimps by liquid chromatography–mass spectrometry

Cited by 76 publications

References 7 publications

Electrochemical Analysis of Chloramphenicol Using Boron-doped Diamond Electrode Applied to a Flow-Injection System

Electrochemical Analysis of Chloramphenicol Using Boron-doped Diamond Electrode Applied to a Flow-Injection System

Competitive immunoassay by capillary electrophoresis with laser‐induced fluorescence for the trace detection of chloramphenicol in animal‐derived foods

Method Development and Validation for Simultaneous Estimation of Dexlansoprazole and Meloxicam by Rp-Hplc

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