Determination of cefsulodin sodium [D(—)-SCE-129] by high-performance liquid chromatography

Elrod, Lee; White, Landy B.; Wimer, D. C.; Cox, Robert D.

doi:10.1016/s0021-9673(00)97643-x

Cited by 7 publications

(1 citation statement)

References 29 publications

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“…Our pellets were large in volume and weight: they contained larger zones ex plored by microelectrode. An assay by HPLC was performed on small brain loci such as the hypothalamus or the caudate nucleus, but this was unsuccessful: the lim it of sensitivity of the HPLC assay was too high; HPLC assay done by others [13,14] did not permit to lower this limit. It is dif ficult to compare these two methods in terms of pharmacokinetics.…”

Section: Discussionmentioning

confidence: 99%

Cefsulodin Penetration into Rat Brain: Extracellular versus Total Concentration

et al. 1986

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Disposition of cefsulodin (125 mg · kg^––¹) was studied in rat frontal cortex after intravenous injection of a bolus by two methods. In vivo voltametry and high performance liquid chromatography of cefsulodin in brain extracts gave different concentration values. The ratio of concentrations determined by the two methods was similar to the ratio of the extravascular volume to total volume. Thus, these findings evidenced the distribution of cefsulodin in the extravascular fluid of the rat frontal cortex.

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Section: Discussionmentioning

confidence: 99%

Cefsulodin Penetration into Rat Brain: Extracellular versus Total Concentration

et al. 1986

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Stability of Cefotaxime Sodium as Determined by High-Performance Liquid Chromatography

Gupta¹

1984

Journal of Pharmaceutical Sciences

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The stability of cefotaxime sodium in water (with either hydrochloric acid, phosphate buffers, or other ingredients) dextrose, and sodium chloride has been studied using a stability-indicating high-performance liquid chromatographic method with a relative standard deviation of 1.9% based on six injections. The optimum pH range of stability was determined to be approximately 4.3-6.2. In this pH range, the decomposition process was catalyzed only by the solvent. At pH less than or equal to 3.4, the hydrogen ion also catalyzed the reaction while at pH greater than 6.2, the hydroxyl ion hastened the process of decomposition. The solutions in 5% dextrose and 0.9% NaCl injections were stable for at least 1, 22, and 112 d at 24 degrees C, 4 degrees C, and -10 degrees C, respectively. For both solutions, the loss in potency was less than 5% at -10 degrees C in 224 d, less than 9% at 4 degrees C in 42 d, and less than 3.1% at 24 degrees C in 1 d.

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Penicillins and cephalosporins

Krimpen

Bennekom

Bult

1987

Pharmaceutisch Weekblad Scientific Edition

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Penicillins and cephalosporins belong to the most prescribed antibiotics. Despite the relatively extended knowledge of these drugs, the qualitative and quantitative analysis of the compounds still gives rise to many problems. These difficulties are due to the chemical instability of the common beta-lactam nucleus, the minor differences in chemical structures between the analogues, and the complex and relatively fast degradation of the compounds in aqueous solutions. In this review a compilation of the physicochemical properties, the degradation routes and methods for analysis of these substances in biological and other matrices is presented.

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Determination of cefsulodin sodium [D(—)-SCE-129] by high-performance liquid chromatography

Cited by 7 publications

References 29 publications

Cefsulodin Penetration into Rat Brain: Extracellular versus Total Concentration

Cefsulodin Penetration into Rat Brain: Extracellular versus Total Concentration

Stability of Cefotaxime Sodium as Determined by High-Performance Liquid Chromatography

Penicillins and cephalosporins

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