Determination of biogenic amines in alcoholic beverages by ion chromatography with suppressed conductivity detection and integrated pulsed amperometric detection

Borba, Brian M. De; Rohrer, Jeff

doi:10.1016/j.chroma.2007.01.114

Cited by 70 publications

(23 citation statements)

References 29 publications

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“…It helped to extend the range of the determined substances with carbohydrates, alcohols, and catecholamines [50]. In ion chromatography, the amperometric detector is used to determine, for example, sulfides [51], cyanides, sulfides, thiosulfates [52], iodides [53], biogenic amines [54], or carbohydrates [55]. The potentiometric detector operations are based on the measurement of the potential formed between the miniaturized ion-selective electrode and analyzed solution.…”

Section: Detection Methodsmentioning

confidence: 99%

Principles and Applications of Ion Chromatography

Michalski¹

2016

Application of IC‐MS and IC‐ICP‐MS in Environmental Research

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Section: Detection Methodsmentioning

confidence: 99%

Principles and Applications of Ion Chromatography

Michalski¹

2016

Application of IC‐MS and IC‐ICP‐MS in Environmental Research

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“…In the Republic of Macedonia, the maximal content of biogenic amines in wines has not yet been officially established. The biogenic amines that have toxicological effects (HIST, TYR, TRP and PEA) [9,12,16,17,25] were in the ranges: 1.20-9.62 mg/l for TYR, 0.07-4.30 mg/l for HIST, 0.93-15.0 mg/l for PEA and 1.20-9.40 mg/l for TRP. PUT and CAD were also found in red wines at higher concentrations than in white wines and the quantities were in the following ranges: PUT: 10.3 mg/l to 16.6 mg/l for red wines and 0.37 to 8.68 mg/l for white wines; and CAD: 0.06 to 1.26 mg/l and 0.13 to 0.21 mg/l for the red and white wines, respectively.…”

Section: Application Of the Methods On Wine Samples Analysismentioning

confidence: 99%

“…The health risks arising from the presence of biogenic amines are related to symptoms such as nausea, respiratory discomfort, hot flushes, cold sweat, palpitations, headaches, red rash, high or low blood pressure, intracerebral hemorrhage or even death [9,12,16,17]. The most problematic biogenic amine is histamine, which causes headaches, low blood pressure, heart palpitations, edema, vomiting and diarrhea [1,[18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Optimization and validation of a derivatization method for analysis of biogenic amines in wines using RP-HPLC-DAD

Tashev¹,

Ivanova-Petropulos

Стефова

2016

Maced. J. Chem. Chem. Eng.

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An analytical method for determination of the biogenic amines tryptamine, putrescine, histamine, phenylethylamine, tyramine, cadaverine, spermidine and spermine in red and white wines using precolumn derivatization with dansyl chloride (DnsCl) and reversed phase-high performance liquid chromatography with diode array detector (RP-HPLC-DAD) was developed and optimized. The concentration of DnsCl, pH, time of reaction and evaporation under nitrogen were tested and optimized. Best recoveries, ranging from 72 to 102 % were obtained for all analyzed amines applying derivatization with 10 mg/ml of DnsCl for 1 h at 60 ºC and pH 9. The developed method showed excellent linearity with R 2 > 0.99 for all of the tested amines. The accuracy was checked with the standard addition method showing satisfactory recovery, good repeatability and reproducibility. The optimized and validated method was applied for the analysis of white and red wines from Macedonian origin, observing higher total amounts of biogenic amines in red wines. The content of the individual biogenic amines was below the maximal allowed concentration in all tested wines.Keywords: wine; biogenic amines; HPLC; derivatization; dansyl chloride; validation ОПТИМИЗАЦИЈА И ВАЛИДАЦИЈА НА МЕТОД ЗА АНАЛИЗА НА БИОГЕНИ АМИНИ ВО ВИНА СО ПРИМЕНА НА RP-HPLC-DADРазвиен е и оптимизиран аналитички метод за определување на биогените амини трип-тамин, путрескин, хистамин, фенилетиламин, тирамин, кадаверин, спермидин и спермин во црвени и бели винa со примена на претколонска дериватизација со дансилхлорид (DnsCl) и реверзно-фазна високоефикасна течна хроматографија со детектор со низа од диоди (RP-HPLC-DAD). Концентрацијата на DnsCl, pH, времето на реакцијата и испарувањето со азот беа тестирани и оптимизирани. За сите анализирани амини беа постигнати најдобри аналитички приноси во граници од 70 до 102 %, применувајќи дериватизација со раствор од DnsCl со концентрација од 10 mg/ml, за време од 1 h на 60 ºC и pH 9. Развиениот метод се карактеризира со одлична линеарност со R 2 > 0.99 за сите анализирани амини. Точноста на методот беше проверена со метод на стандарден додаток, при што беа добиени задоволителни вредности за аналитичкиот принос, добра повторливост и репродуцибилност. Оптимизираниот и валидиран метод беше применет за анализа на бели и црвени вина од македонско потекло, при што повисоки вредности на вкупните амини беа забележани во црвените вина. Во сите вина содржината на индивидуалните биогени амини беше пониска од максимално дозволената концентрација.Клучни зборови: вино; биогени амини; HPLC; дериватизација; дансилхлорид; валидација K. Tašev, V. Ivanova-Petropulos, M. Stefova Maced.

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“…A certain amount of monamines have great regulation effects on mentation and cerebral cortex and low level of polyamines are necessary for the growth of organisms (Ali Awan, Fleet, & Paul Thomas, 2008;Önal, Tekkeli, & Önal, 2013). Consequently, BAs are not considered a grave risk for humans if they are present in low levels in foods (De Borba & Rohrer, 2007;Innocente, Biasutti, Padovese, & Moret, 2007). However, excessive intake of BAs has various toxicological implications (e.g., histamine intoxication, hypertensive crises, dizziness, and migraine headaches) (Beneduce et al, 2010;Özdestan & Üren, 2009).…”

Section: Introductionmentioning

confidence: 97%

“…Therefore, rice wine is likely to produce high levels of BAs. Generally speaking, PUT, CAD, HIS, TYR and PHE are abundant in rice wine (De Borba & Rohrer, 2007). Since the consumption of food containing high concentrations of BAs may cause toxic reactions in susceptible individuals.…”

Section: Introductionmentioning

confidence: 99%