Determination of benzalkonium chloride by reversed-phase high-pressure liquid chromatography

Meyer, Roger

doi:10.1002/jps.2600691006

Cited by 36 publications

(2 citation statements)

References 7 publications

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“…T h e area under the peak for each homologue responded linearly with concentration within the range examined. Variation in the proportion of homologues is possible from different sources of benzalkonium chlorides (5,10,12), therefore commercial 0~02",w/v, 509,w/v and solid benzalkonium chloride preparations were purchased and subjected to the above assay procedure. As can be seen from Table 1, three different batches from the same manufacturer (A) contained roughly the same proportion of the homologues, with the C, , predominating, illustrating good batch to batch consistency.…”

Section: Apparatus and Materialsmentioning

confidence: 99%

“…There are many examples in the literature of non-official methods for assaying benzalkonium chlorides, though many are unable to assess the proportion of homologues (6-9) and many others tend to be unsuitable for routine work ( 5 , lo), the only exceptions are the two HPLC methods. The first method was designed specifically for determining benzalkonium chlorides in the presence of alkaloids and polymeric substrates (1 1) in contrast to the second method which simply determined them in very dilute aqueous solutions (12).…”

Section: Introductionmentioning

confidence: 99%

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High Performance Liquid Chromatography of Benzalkonium Chlorides-Variation in Commercial Preparations

Euerby

2008

Journal of Clinical Pharmacy and Therapeutics

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High performance liquid chromatography (HPLC) has been used to identify and determine the various alkyl benzyldimethylammonium chloride homologues (C***10 to C16) present in commercial benzalkonium chloride preparations. The assay is especially suited for routine quality control work since it has proved to be quick and easily reproducible. It has been found that there can be a large degree of variation in the quality of differing benzalkonium chloride sources.

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Section: Apparatus and Materialsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High Performance Liquid Chromatography of Benzalkonium Chlorides-Variation in Commercial Preparations

Euerby

2008

Journal of Clinical Pharmacy and Therapeutics

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Zur Analytik des Benzalkoniumchlorids

Herrmann

1987

Archiv der Pharmazie

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Analyse beträgt in Lösungen von 1.5 mg/ml f 1.52 % ( s , , , n = 1 i), in Tabletten mit 1 mg/Dosis f 3.3 % (n = 9). The Quantitation of Benzalkonium ChlorideBenzalkonium chloride is a mixture of homologous alkyl(benzy1)dimethylammonium chlorides. For the quantitative determination of benzalkonium chloride, the ratio of the homologues must be known. This can be easily determined by hplc on a cyano column and is the basis for the volumetric determination of the benzalkonium chloride content of a standard. On this standard is based the quantitative hplc analysis of pharmaceutical products, which is required to assess the stability ofthe active principle in liquid and solid preparations. The reproducibility of the method is I 1.52 % (Q, n = 1I)in solutions with a concentration of about 1.5 mg/ml and I 3.3 % (n = 9) in tablets with 1 mg/dose.

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