Determination of Aucubin and Catalpol in Plantago Species by Micellar Electrokinetic Chromatography

Jurišić, Renata; Debeljak, Željko; Vladimir‐Knežević, Sanda; Vuković, Jadranka

doi:10.1515/znc-2004-1-206

Cited by 19 publications

(8 citation statements)

References 1 publication

(2 reference statements)

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“…The aucubin concentration in the Et ranged from 0.98 to 4.18%, whereas in the GL and CT the concentrations were 0.65 and 1.78%, respectively (Table 1). In another study it has been reported that the aucubin concentration in PL is 0.27% (Jurisic et al . 2004), which is much lower than the present results.…”

Section: Resultsmentioning

confidence: 98%

Comparison of the bioactive components of the ecotypes and cultivars of plantain (Plantago lanceolata L.) herbs

Al-Mamun

Abe

Kofujita

et al. 2008

Animal Science Journal

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The concentrations of the bioactive components, acteoside, aucubin and catalpol, and the production yield, crude protein (CP) and crude ash contents in 25 ecotypes (Et) of plantain (PL, Plantago lanceolata L.), found in northern Japan, and commercial cultivars, Grasslands Lancelot (GL) and Ceres Tonic (CT), were investigated. The quantitative determination of bioactive components was performed by high performance liquid chromatography. The acteoside content of some of the 25 Et was significantly higher (P < 0.05) than CT and numerically higher than GL and other Et. Most of the Et had numerically higher concentrations of catalpol and aucubin than the GL and CT. The CP and crude ash content of the Et were comparable with those of the GL and CT. The dry matter (DM) yields of some of the Et was numerically greater than that of the cultivars. The present data suggest that most of the Et are comparable to the cultivars in respect to the concentration of bioactive components and DM yield as well as CP and crude ash contents and could be used as pasture like GL and CT.Means with different superscript in the same column are significantly different (P < 0.05). A,

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Section: Resultsmentioning

confidence: 98%

Comparison of the bioactive components of the ecotypes and cultivars of plantain (Plantago lanceolata L.) herbs

Al-Mamun

Abe

Kofujita

et al. 2008

Animal Science Journal

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“…Medicinally, Plantago species are astringents, demulcents, emollients, expectorants, diuretics, antibacterials and antivirals [15]. Phytochemical investigations of Plantago species revealed the presence of iridoids, flavonoids, tannins, triterpenes, saponins, and sterols [15][16][17][18]. Phenolic compounds such as phenylpropanoid glucoside, plantamajoroside, rosmarinic and chlorogenic acid as well as luteolin-7-O-monoglucoside were isolated from Plantago lagopus L. [19].…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric method for polyphenols analysis: Prevalidation and application on Plantago L. species

Grubešić

Vuković

Kremer

et al. 2005

Journal of Pharmaceutical and Biomedical Analysis

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“… 12 Aucubin is one of the main components of Plantaginis Semen . 13 Thus, the antiallodynic effect of aucubin, its precursor geniposide acid, and its metabolite catalpol were also tested. Prophylactic repetitive administration of aucubin attenuated the exacerbation of PTX-induced mechanical allodynia.…”

Section: Discussionmentioning

confidence: 99%

Prophylactic administration of an extract from Plantaginis Semen and its major component aucubin inhibits mechanical allodynia caused by paclitaxel in mice

Andoh

Kato

Kitamura

et al. 2016

Journal of Traditional and Complementary Medicine

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The chemotherapeutic agent paclitaxel (PTX) causes peripheral neuropathy as a major dose-limiting side effect, and this peripheral neuropathy is difficult to control. Our previous report showed that prophylactic repetitive administration of goshajinkigan (牛車腎氣丸 niú chē shèn qì wán), but not hachimijiogan (八味地黃丸 bā wèi dì huáng wán), which lacks two of the constituents of goshajinkigan, inhibited PTX-induced mechanical allodynia in mice. Thus, the herbal medicines Plantaginis Semen (車前子 chē qián zǐ) or Achyranthis Radix (牛膝 niú xī) may contribute to the inhibitory action of goshajinkigan on the exacerbation of PTX-induced mechanical allodynia [Andoh et al, J. Tradit. Complement. Med. 2014; 4: 293–297]. Therefore, in this study, we examined whether an extract of Plantaginis Semen (EPS) or Achyranthis Radix (EAR) would relieve PTX-induced mechanical allodynia in mice. A single intraperitoneal injection of PTX caused mechanical allodynia, which peaked on day 14 after injection. Repetitive oral administration of EPS, but not EAR, starting from the day after PTX injection significantly inhibited the exacerbation of PTX-induced mechanical allodynia. Repetitive intraperitoneal injection of aucubin, one of the main components of EPS, starting from the day after PTX injection also significantly reduced PTX-induced mechanical allodynia. However, repetitive intraperitoneal injection of geniposide acid (a precursor of aucubin) or catalpol (a metabolite of aucubin) did not prevent the exacerbation of mechanical allodynia. These results suggest that prophylactic administration of EPS is effective for preventing the exacerbation of PTX-induced allodynia. Aucubin may contribute to the inhibitory action of EPS on the exacerbation of PTX-induced allodynia.

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Determination of Aucubin and Catalpol in Plantago Species by Micellar Electrokinetic Chromatography

Cited by 19 publications

References 1 publication

Comparison of the bioactive components of the ecotypes and cultivars of plantain (Plantago lanceolata L.) herbs

Comparison of the bioactive components of the ecotypes and cultivars of plantain (Plantago lanceolata L.) herbs

Spectrophotometric method for polyphenols analysis: Prevalidation and application on Plantago L. species

Prophylactic administration of an extract from Plantaginis Semen and its major component aucubin inhibits mechanical allodynia caused by paclitaxel in mice

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