Determination of anti‐inflammatory drugs and estrogens in water by HPLC with UV detection

Stafiej, J.; Pyrzyńska, Krystyna; Regan, Fiona

doi:10.1002/jssc.200600433

Cited by 121 publications

(56 citation statements)

References 20 publications

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“…The sensitivity of method expressed as Limit of Detection (LOD) and Limit of Quantification (LOQ) values were calculated based on linear regression method ranges from 2.5-11.7 and 7.5-35.4 µg L −1 , respectively. The LOD and LOQ for this method were lower than those reported whereby the LOD and LOQ ranges from 6-74 and 60-200 µg L −1 , respectively (Chandra and Dutt Sharma, 2013;Stafiej et al, 2007). The LOD and LOQ values are also comparable to those reported in the literature (Aguilar-Arteaga et al, 2010).…”

Section: Methods Validationsupporting

confidence: 76%

Direct Analysis of Six Pharmaceuticals using Online Solid Phase Extraction Liquid Chromatography

Subari¹,

Osman²,

Saim³

2017

American Journal of Applied Sciences

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In this study, three parameters (sample volume, cleanup and elution step) in large volume injection online Solid Phase Extraction Liquid Chromatography with diode array detection (SPE-LC) were optimized for the determination of six pharmaceuticals in wastewater samples. Preconcentration and separation were carried out using 2 columns, Dionex Ion Pac AG14A and Acclaim Polar Advantage II. Response Surface Methodology (RSM) was employed for the optimization of cleanup step (mobile phase composition and valve switching time). The optimum conditions obtained were as follows: Sample volume of 10.0 mL and cleanup with acetonitrile and ultrapure water (5:95) for 1.0 min. The method showed good recovery (82.91-107.7%), precision (0.35-8.26%) and linearity (R 2 >0.99). The limit of detection was between 3.5 and 11.7 µg L −1 . The proposed method is rapid, simple and sensitive for trace analysis of pharmaceuticals in water samples.

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Section: Methods Validationsupporting

confidence: 76%

Direct Analysis of Six Pharmaceuticals using Online Solid Phase Extraction Liquid Chromatography

Subari¹,

Osman²,

Saim³

2017

American Journal of Applied Sciences

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“…It was known that diethylstilbestrol and estriol were bound to the estrone-imprinted polymer by hydrophobic interaction (that is non-specific adsorption) and it was easier to destroy this interaction by addition of methanol [30]. Acetic acid can increase the eluting strength, weaken the binding of template to the imprinted polymer, and release the template from the imprinted cavity of the stationary phase more quickly [4]. The effect of the concentration of acetic acid in the eluent was studied in the range of 0.1 to 6.0%.…”

Section: Optimization Of the Mispe Processmentioning

confidence: 99%

Separation and determination of estrone in environmental and drinking water using molecularly imprinted solid phase extraction coupled with HPLC

Wang¹,

Fang

et al. 2008

J of Separation Science

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Estrone has been identified as an important potential endocrine-disrupting compound, so that sensitive and reliable analytical methods are required for its determination and the assurance of human health. Using estrone as the template, acrylamide as the functional monomer, and methacryloxypropyltrimethoxysilane as the cross-linker, an organic-inorganic hybrid material has been synthesized by the molecular imprinting technique combined with a non-hydrolytic so-gel process. The synthesized polymer was characterized by FT-IR and static adsorption experiments, and the results showed that it had good recognition and selective ability for estrone. A novel method for separation and determination of trace estrone in water samples was developed using molecularly imprinted solid phase extraction coupled with HPLC. Under the selected experimental condition, the detection limit (S/N = 3) was 9.3 ng/L, and the RSD for five replicate extractions of 10 mug/L estrone was less than 5.0%. This method was employed for quantitative determination of estrone in river, lake, and tap water with recoveries ranging from 83.38 to 98.12%.

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“…The hydrogen bonds between MAA and 4-(dimethoxyphosphorothioylamino)butanoic acid were weak and could be broken by acetic acid. 30 As a result, specific recognition sites and imprinted cavities were formed after removal of the template molecule, and the MIP monolithic column was synthesized.…”

Section: Sample Preparationmentioning

confidence: 99%

Synthesis and Evaluation of Organic–Inorganic Hybrid Molecularly Imprinted Monolith Column for Selective Recognition of Acephate and Phosphamidon in Vegetables

Wang

Zhang

et al. 2015

Adv Polym Technol

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ABSTRACT:In this study, a molecularly imprinted capillary monolithic column that can recognize the acephate and phosphamidon was synthesized by the molecular imprinting technique combined with a nonhydrolytic sol-gel process using intermediate 4-(dimethoxyphosphorothioylamino)butanoic acid as the template molecule. The resulting material was characterized by scanning electron microscopy and Fourier transform infrared spectroscopy. The potential of the prepared imprinted monolithic columns used as the stationary phase for capillary electrochromatography (CEC) was evaluated. The effects of operating voltage, pH, and acetonitrile content on the electroosmotic flow of the imprinted monolithic columns were evaluated in CEC. Under optimal conditions, the cucumber and lettuce samples spiked with acephate and phosphamidon were extracted and analyzed by this method with satisfactory recoveries ranging from 79.7 to 94.4%. The relative standard deviation for five replicates of 0.1 mg/L mixed solution of acephate and phosphamidon was in the range of 2.7-4.6%. C

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Determination of anti‐inflammatory drugs and estrogens in water by HPLC with UV detection

Cited by 121 publications

References 20 publications

Direct Analysis of Six Pharmaceuticals using Online Solid Phase Extraction Liquid Chromatography

Direct Analysis of Six Pharmaceuticals using Online Solid Phase Extraction Liquid Chromatography

Separation and determination of estrone in environmental and drinking water using molecularly imprinted solid phase extraction coupled with HPLC

Synthesis and Evaluation of Organic–Inorganic Hybrid Molecularly Imprinted Monolith Column for Selective Recognition of Acephate and Phosphamidon in Vegetables

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