Determination of Alendronate Sodium in Tablets by Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy

Ibrahim, S.A.; Khalivulla, Shaik Ibrahim; Akowuah, Gabriel Akyirem

doi:10.2174/1573407212999160506112738

Cited by 7 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By FTIR analysis the characteristic bands of AL were highlighted at 1016.41 (ν ( P-O) —asym), 1045.34 (ν ( P-O) —asym), 1124.42 (ν (P=O) —H bonds), 1174.56 (ν (P=O) —H bonds), and 1228.57 cm −1 (ν ( P=O) —asym) and were related to P-O and P=O bond length stretching. Also, we tracked the intensity change of the peak corresponding to the phosphate group of alendronate (1541.22 cm −1 ) [33]. All these specific bands were marked on Figure 1 (right) with dotted lines.…”

Section: Resultsmentioning

confidence: 99%

Alendronate-Loaded Modified Drug Delivery Lipid Particles Intended for Improved Oral and Topical Administration

Ochiuz

Grigoraş²,

Popa

et al. 2016

Molecules

View full text Add to dashboard Cite

Abstract:The present paper focuses on solid lipid particles (SLPs), described in the literature as the most effective lipid drug delivery systems that have been introduced in the last decades, as they actually combine the advantages of polymeric particles, hydrophilic/lipophilic emulsions and liposomes. In the current study, we present our most recent advances in the preparation of alendronate (AL)-loaded SLPs prepared by hot homogenization and ultrasonication using various ratios of a self-emulsifying lipidic mixture of Compritol 888, Gelucire 44/14, and Cremophor A 25. The prepared AL-loaded SLPs were investigated for their physicochemical, morphological and structural characteristics by dynamic light scattering, differential scanning calorimetry, thermogravimetric and powder X-ray diffraction analysis, infrared spectroscopy, optical and scanning electron microscopy. Entrapment efficacy and actual drug content were assessed by a validated HPLC method. In vitro dissolution tests performed in simulated gastro-intestinal fluids and phosphate buffer solution pH 7.4 revealed a prolonged release of AL of 70 h. Additionally, release kinetics analysis showed that both in simulated gastrointestinal fluids and in phosphate buffer solution, AL is released from SLPs based on equal ratios of lipid excipients following zero-order kinetics, which characterizes prolonged-release drug systems.

show abstract

Section: Resultsmentioning

confidence: 99%