Determination of 5-aminosalicylic acid in pharmaceutical formulations by square wave voltammetry at pencil graphite electrodes

Abstract

Recebido em 9/6/09; aceito em 24/11/09; publicado na web em 2/3/10 An analytical method for the determination of the anti-inflammatory drug 5-aminosalicylic acid (5-ASA) in pharmaceutical formulations using square wave voltammetry at pencil graphite electrodes was developed. After the optimization of the experimental conditions, calibration curves were obtained in the linear concentration range from 9.78 × 10 -7 to 7.25 × 10 -5 mol L -1 resulting in a limit of detection of 2.12 ± 0.05 x 10 -8 mol L -1. Statistical tests showed that the concentrations of 5-ASA in commercial tablets and enemas obtained with the proposed voltammetric method agreed with HPLC values at a 95% confidence level.

Investigation of the Electrochemical Behavior of Mesalazine on the Surface of a Glassy Carbon Electrode Modified with CNT/PPY Doped by 1,5‐Naphthalenedisulfonic Acid

“…At low pH values, the amino group of MSA associates one proton (NH 3 + ), so the oxidation process becomes more difficult; it means that higher potential is necessary for the oxidation. Above pH 6, H + is released from NH 3 + , and lower potential is needed for the oxidation of MSA 25. The intersection point observed at pH 6 can be attributed to the p K a2 value of 5.8 reported in the literature for the NH 3 + group of MSA 24.…”

Evaluation of the interactions of DNA with the textile dyes Disperse Orange 1 and Disperse Red 1 and their electrolysis products using an electrochemical biosensor

“…The leads were first cleaned with absorbent paper to remove particles from the surface, and the geometric area was selected by wrapping Parafilm TM (American National Can Co., USA) around the pencil lead at a height of 3.0 mm, corresponding to a geometric electrode area of 0.091 cm 2 . The electrical contact was made directly from the other side of the pencil lead [38]. Electrochemical experiments were performed using the AUTOLAB PGSTAT 30 and GPES 4.9 software packages (Eco Chemie, The Netherlands).…”

Voltammetric/amperometric screening of compounds of pharmacological interest

“…Analgesics (acetaminophen, morfine) C Garcia-Fernandez et al 2000, Ni et al 2004, Uliana et al 2010, Ozcan and Sahin 2011GC Garrido et al 2002, Garrido et al 2003a,b, Torriero et al 2006, Kashefi-Kheyrabadi and Mehrgardi 2012BDD Wangfuengkanagul and Chailapakul 2002, Lourenção et al 2009, Sartori et al 2009, Švorc et al 2012aCNT Wan et al 2009a,b, Goyal et al 2010a,b,c,d,e, Sanghavi and Srivastava 2010,b, Shahrokhian and Asadian 2010, Habibi et al 2011, Lu and Tsai 2011, Arvand and Gholizadeh, 2013 Vela et al 2001, El-Enany et al 2002, Ozaltin et al 2002, Ozaltin et al 2002, Morais et al 2003, Nouws et al 2005a,b, 2006a Belal et al 2001a,b, 2002a, 2001b, 2003, Dumitrescu et al 2001, Ghandour et al 2001, El-Ries et al 2002, Tamer et al 2002, Demircigil et al 2003, Ghoneim and Tawfik 2003a,b, Ioannides et al 2003, Prieto et al 2003, Razak et al 2003 Several general aspects dealing with the voltammetric screening of pharmaceuticals can be applied: -Electrode modification strategies generally used to promote an electrocatalytic effect on the oxidation or reduction of the analyte. In most cases, synergistic eff...…”