Determination of 25-OCH3-PPD and the related substances by UPLC–MS/MS and their cytotoxic activity

Ding, Meng; Lu, Jingjing; Zhao, Chen; Zhang, Sainan; Zhao, Yuqing

doi:10.1016/j.jchromb.2016.04.031

Cited by 6 publications

(3 citation statements)

References 14 publications

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“…The research conditions force the drug compounds to degrade under tremendous conditions such as acid and base hydrolysis, peroxide oxidation, photo-oxidation, and thermal stability to identify the resultant degradation products. Stability indicating method using UHPLC-MS/MS is included in Table 4 [147][148][149][150][151][152][153] Impurity profile of drug using UHPLC/MS/MS For the medicine development and formulation process, profiling, detection, and evaluation of drug substances and their contamination in crude materials and finishing yield testing is an essential part which is summarized in Table 5 [3] [154][155][156][157][158][159][160][161][162][163].…”

Section: Stability-indicating Methods Using Uhplc-ms/msmentioning

confidence: 99%

Ultra-high performance liquid chromatography-MS/MS (UHPLC-MS/MS) in practice: analysis of drugs and pharmaceutical formulations

et al. 2019

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Background: UHPLC-MS/MS is connected in various research facilities for the qualitative and quantitative investigation of a pharmaceutical substance, pharmaceutical items, and biological specimen. Main body: The commence review article is an endeavor to offer pervasive awareness around assorted aspects and details about the UHPLC-MS/MS and related techniques with the aim on practice to an estimation of medicinal active agents in the last 10 years. The article also focused on isolation, separation, and characterization of present impurity in drug and biological samples. Conclusion: Review article compiles a general overview of medicinally important drugs and their analysis with UHPLC-MS/MS. It gives fundamental thought regarding applications of UHPLC-MS/MS for the study on safety limit. The summary of developed UHPLC-MS/MS methods gives a contribution to the future trend and limitations in this area of research.

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Section: Stability-indicating Methods Using Uhplc-ms/msmentioning

confidence: 99%

Ultra-high performance liquid chromatography-MS/MS (UHPLC-MS/MS) in practice: analysis of drugs and pharmaceutical formulations

et al. 2019

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“…Furthermore, a rapid and selective UPLC-MS/MS method was invented for the simultaneous determination of the major constituent and related substances in the raw material of 25-OCH 3 -PPD. The method was successfully applied to establish a reasonable quality control standard for the raw material of 25-OCH 3 -PPD [21].…”

Section: Chemical and Biological Studies Of 25-och 3 -Ppdmentioning

confidence: 99%

25-Methoxyl-Dammarane-3β, 12β, 20-Triol, A Ginseng Saponin Derivative and an Anticancer Agent: In Vitro and In Vivo Activities, Molecular Mechanism of Action, Pharmacokinetics and Structural Modification

Wu¹,

Ding²,

Wang³

et al. 2017

Med chem (Los Angeles)

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12β, -PPD), a dammarane-type triterpene sapogenin isolated from Panax notoginseng, has shown strong antitumor effects in various human cancer cell lines, including prostate cancer, lung cancer, breast cancer, gastric cancer, colorectal cancer, pancreatic cancer, and hepatic fibrosis. This review focuses on the progress of research into 25-OCH 3 -PPD and its derivatives in cancer therapy, including in vitro and in vivo activities, structure-activity relationships, and the molecular mechanisms of action. In addition, we also summarized a method to evaluate the oral subchronic toxicity, improve oral bioavailability, and establish quality control standards for 25-OCH 3 -PPD. In this review, we have provided a detailed discussion of 25-OCH 3 -PPD and supplied a scientific reference for the research and development of 25-OCH 3 -PPD as a potential anticancer drug.

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“…Pentacyclic triterpenoids are a major class of chemical compounds occurring as free acids, esters, or glycosides (saponins) in natural plants and resinous natural materials . In traditional Chinese medicines, many medicinal herbs contain high amounts of pentacyclic triterpenoids, including Ganoderma lucidum (Leyss. ex Fr.)…”

Section: Introductionmentioning

confidence: 99%

Techniques for the analysis of pentacyclic triterpenoids in medicinal plants

Bing

et al. 2017

J of Separation Science

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Triterpenes are a major class of chemical compounds found in natural plants and can be categorized into acyclic triterpenoids, monocyclic triterpenoids, tricyclic triterpenoids, tetracyclic triterpenoids, and pentacyclic triterpenoids. Among them, pentacyclic triterpenoids have gained more extensive attention due to their biological activities, including anti-inflammation, antibacterial, antioxidation, antitumor, anti-HIV, hepatoprotection, and immunological adjuvant properties. In this review, we summarize the extraction and analytical methods for pentacyclic triterpenoids, where more than 56 triterpenes from 49 kinds of plants were involved. The analysis methods include gas chromatography, liquid chromatography, capillary electrophoresis, thinlayer chromatography, supercritical fluid chromatography, NMR spectroscopy, and X-ray spectroscopy. This review provides valuable reference for the determination of pentacyclic triterpenoids in medicinal plants.

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Determination of 25-OCH3-PPD and the related substances by UPLC–MS/MS and their cytotoxic activity

Cited by 6 publications

References 14 publications

Ultra-high performance liquid chromatography-MS/MS (UHPLC-MS/MS) in practice: analysis of drugs and pharmaceutical formulations

Ultra-high performance liquid chromatography-MS/MS (UHPLC-MS/MS) in practice: analysis of drugs and pharmaceutical formulations

25-Methoxyl-Dammarane-3β, 12β, 20-Triol, A Ginseng Saponin Derivative and an Anticancer Agent: In Vitro and In Vivo Activities, Molecular Mechanism of Action, Pharmacokinetics and Structural Modification

Techniques for the analysis of pentacyclic triterpenoids in medicinal plants

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