Determination by chromatography and cytotoxotoxic and oxidative effects of pyriproxyfen and pyridalyl

Alves, Patrícia e Silva; Oliveira, Maria das Dores Alves de; Almeida, Pedro Marcos de; Martins, Francielle Alline; Cavalcante, Ana Amélia de Carvalho Melo; Andrade, Teresinha de Jesus Aguiar dos Santos; Feitosa, Chistiane Mendes; Rai, Mahendra; Reis, Antonielly Campinho dos; Júnior, Joaquim Soares da Costa

doi:10.1016/j.chemosphere.2019.02.037

Cited by 13 publications

(4 citation statements)

References 38 publications

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“…Increased SOD and CAT was demonstrated by Alves et al, 2019, when testing increasing concentrations (0.0001 to 1000 ppm) of commercial larvicide containing PPF and pyridalyl against different isogenic lines of Saccharomyces cerevisiae deficient in the antioxidant defenses, SOD and CAT. Corroborating our present findings, ROS generation and the increased activities of the antioxidant defenses SOD, CAT, and GST, associated with decreased GSH levels were demonstrated in D. rerio embryos exposed to 5.2 μM PPF for 96 hpf (hours post fertilization) (Maharajan et al, 2018).…”

Section: Discussionmentioning

confidence: 90%

“…Increased SOD and CAT was demonstrated by Alves et al, 2019, when testing increasing concentrations (0.0001 to 1000 ppm) of commercial larvicide containing PPF and pyridalyl against different isogenic lines of Saccharomyces cerevisiae deficient in the antioxidant F I G U R E 2 Effects of pyriproxyfen exposure on the histomorphology of zebrafish ovaries. Photomicrographs of zebrafish ovaries for control group (A) and pyriproxyfen-exposed group (B) stained with hematoxylin-eosin.…”

Section: Discussionmentioning

confidence: 99%

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In vivo exposure to pyriproxyfen causes ovarian oxidative stress and inhibits follicle maturation in zebrafish

Oliveira

Marins

Mendes

et al. 2023

J of Applied Toxicology

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We analyzed the effects of pyriproxyfen (PPF) on oxidative stress and ovarian morphology in zebrafish. PPF (10−9 M) exposure increased reactive oxygen species generation in ovaries, in association with a decrease in glutathione content. The activities of glutathione S‐transferase, superoxide dismutase, and catalase were increased, while γ‐glutamyltransferase activity was not altered by pesticide treatment. The histology of ovarian tissue showed an increase in the number of previtellogenic oocytes I, and a decrease in the rate of vitellogenic oocyte (VIT) count, suggesting inhibition of follicular maturation. An increase in the thickness of the vitelline envelope was observed in VIT, as was a tendency toward an increase in atresia in the ovary of the PPF‐treated group. These findings indicate that the deleterious effect of PPF on ovarian maturation is mediated by a redox imbalance and oxidative damage. So, PPF acts as an endocrine disruptor chemical and may compromise fish reproduction by reducing female fertility.

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Section: Discussionmentioning

confidence: 90%

“…Increased SOD and CAT was demonstrated by Alves et al, 2019, when testing increasing concentrations (0.0001 to 1000 ppm) of commercial larvicide containing PPF and pyridalyl against different isogenic lines of Saccharomyces cerevisiae deficient in the antioxidant F I G U R E 2 Effects of pyriproxyfen exposure on the histomorphology of zebrafish ovaries. Photomicrographs of zebrafish ovaries for control group (A) and pyriproxyfen-exposed group (B) stained with hematoxylin-eosin.…”

Section: Discussionmentioning

confidence: 99%

In vivo exposure to pyriproxyfen causes ovarian oxidative stress and inhibits follicle maturation in zebrafish

Oliveira

Marins

Mendes

et al. 2023

J of Applied Toxicology

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“…Additionally, the results demonstrated that there were no significant differences between treatments and treatments with the negative control; but, there was a significant difference (p < 0.01) between treatment F3 with the positive control, indicating the high biocompatibility of the materials (Figure 6). We expected a death increase after 48 h. Usually, cytotoxicity depends on compounds' concentration and exposure time [46]. A slight increase in mortality was found for F2 between 24 and 48 h (from 5 to 6%).…”

Section: Biocompatibility Assay With Artemia Salinamentioning

confidence: 85%

Biocompatibility Assessment of Two Commercial Bone Xenografts by In Vitro and In Vivo Methods

2022

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Bone substitutes based on xenografts have been used for a long time in bone regeneration thanks to their inductive capacity for bone tissue regeneration. Some bone-based scaffolds have been modified by adding collagen and other proteins to improve their regenerative capacity and prevent migration and aggregation, especially particles. However, rejection of this graft has been reported due to protein residues caused by poor material preparation. We compared the in vitro and in vivo biological response of two commercial xenografts (InterOss®, F1 and InterOss® Collagen, F2) and a commercial porcine collagen membrane (InterCollagen® Guide, F3) as a rapid degradation control. Fourier Transform Infrared Spectroscopy (FT-IR) analysis evidenced the presence of hydroxyl, orthophosphate, and carbonate groups of the xenografts and amide groups of collagen. Thermogravimetric analysis (TGA) of the xenografts demonstrated their thermal stability and the presence of a few amounts of organic material. The study by differential scanning calorimetry showed the presence of endothermic peaks typical of the dehydration of the xenografts (F1 and F2) and for the collagen membrane (F3), the beginning of structural three-dimensional protein changes. Subsequently, in vitro biocompatibility tests were carried out for the materials with Artemia salina and MTT cell viability with HeLa cells, demonstrating the high biocompatibility of the materials. Finally, in vivo biocompatibility was studied by implanting xenografts in biomodels (Wistar rats) at different periods (30, 60, and 90 days). The F1 xenograft (InterOss) remained remarkably stable throughout the experiment (90 days). F2 (InterOss Collagen) presented a separation of its apatite and collagen components at 60 days and advanced resorption at 90 days of implantation. Finally, the collagen membrane (F3) presented faster resorption since, at 90 days, only some tiny fragments of the material were evident. All the in vivo and in vitro test results demonstrated the biocompatibility of the xenografts, demonstrating the potential of these materials for tissue engineering.

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“…There are several mechanisms associated with larval mortality, such as substances that directly affect the central nervous system [47], compounds that act on acetylcholine receptors and GABA ion channels [48], and alterations in juvenile hormone [49].…”

Section: Resultsmentioning

confidence: 99%

Valorization of deodorizing distillate palm oil residue for larvicidal activity against Aedes aegypti and synergistic effect of their free fatty acids

Ribeiro,

LOPES,

Marinho

et al. 2023

Preprint

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Increased consumption of palm oil results in more palm oil by-products. To meet environmental sustainability, deodorizing distillate palm oil (DDPO) also calls attention to diversifying its technological or commercial application. Because of this, the present work, to present new economic-scientific alternatives for this by-product, aimed to evaluate the larvicide effect of DDPO, well as to investigate the synergistic effect of the combination of these fatty acid present in the composition of DDPO, against larvae of 3rd instar of Ae. aegypti. The DDPO larvicide assay showed a high mortality rate, with an LC50 of 6.18 µg.mL− 1 at 24 h and 8.73 µg.mL− 1 at 48 h of treatment. In addition, the results of LC50, among saturated fatty foods and between the combination of fatty acid (myristic, lauric, stearic and oleic) with palmitic acid, were met positively by second-degree polynomial regression analysis. Finally, the study of molecular docking, corroborated, as potential inhibitors of the binding of juvenile hormones. Together, the results suggest that DDPO can be a potential natural larvicide agent, making it an alternative to the excessive use of synthetic insecticides, thus minimizing its impacts on the environment and promoting new technologies for the use of this palm oil by-product.

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Determination by chromatography and cytotoxotoxic and oxidative effects of pyriproxyfen and pyridalyl

Cited by 13 publications

References 38 publications

In vivo exposure to pyriproxyfen causes ovarian oxidative stress and inhibits follicle maturation in zebrafish

In vivo exposure to pyriproxyfen causes ovarian oxidative stress and inhibits follicle maturation in zebrafish

Biocompatibility Assessment of Two Commercial Bone Xenografts by In Vitro and In Vivo Methods

Valorization of deodorizing distillate palm oil residue for larvicidal activity against Aedes aegypti and synergistic effect of their free fatty acids

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