Determination and pharmacokinetic study of pirfenidone in rat plasma by UPLC–MS/MS

Determination of isavuconazole in rat plasma by UPLC-MS/MS: application to a pharmacokinetic study

“…It is recognized as a powerful tool for the quantitative determination of active compounds in biological samples as compared to standard HPLC. [12][13][14] It is universalized especially in both laboratories and hospitals because of its various advantages.…”

Determination of baicalin and ginsenoside Re in Banxia-Xiexin decoction using pharmacokinetics and icELISA analysis in mice. Effects of interaction between prescription herbs on the pharmacokinetics of compounds

“…For example, a recent study of drug compatibility demonstrated that the combination of Radix Aconiti Laterlis with Radix Glycyrrhizae resulted in signicant changes in the pharmacokinetics of aconitine, mesaconitine and hypaconitine detected in rat plasma. The feasibility of these methods have been validated, [8][9][10][11] despite the fact that they require relatively large amounts of samples for testing and complex pre-treatment methods for detection. 6 In addition to metabolism, the combination and dose of herbs may alter absorption of the medicine.…”

“…7 Currently, besides high-performance liquid chromatography (HPLC), numerous bioanalytical methods have been developed and applied in pharmacokinetic studies in vivo, such as liquid chromatography-mass spectrometry (LC-MS), liquid chromatography-tandem mass spectrometry (LC-MS/MS) and ultra-fast liquid chromatography-tandem mass spectrometry (UFLC-MS/ MS). The feasibility of these methods have been validated, [8][9][10][11] despite the fact that they require relatively large amounts of samples for testing and complex pre-treatment methods for detection. In this study, a more practical approach, indirect competitive enzyme-linked immunosorbent assay (icELISA) was applied, which is based on small molecule monoclonal antibodies and has high sensitivity and specicity.…”