Determination and modeling of aqueous solubility of 4-position substituted benzoic acid compounds in a high-temperature solution

Sunsandee, Niti; Suren, Sira; Leepipatpiboon, Natchanun; Hronec, Milan; Pancharoen, Ura

doi:10.1016/j.fluid.2012.11.023

Cited by 53 publications

(35 citation statements)

References 39 publications

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“…The λ h equation was proposed in 1980 by Buchowski et al and is used to correlate the solubility of a solute in a liquid solution system or a slightly eutectic system. , The λ h equation is expressed as eq . …”

Section: Thermodynamic Modelsmentioning

confidence: 99%

Solubility Determination and Thermodynamic Modeling of Amitriptyline Hydrochloride in 13 Pure Solvents at Temperatures of 283.15–323.15 K

Shi

Wang

et al. 2021

J. Chem. Eng. Data

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In this work, the solubility of amitriptyline hydrochloride (AMT) in 13 monosolvents was experimentally measured in the temperatures ranging from 283.15 to 323.15 K under atmospheric pressure with the aid of laser dynamic solubility monitor devices. The solubility as a function of temperature in different monosolvents was regressed using two activity coefficient models (Wilson and nonrandom two liquid (NRTL)) and three semiempirical equations (modified Apelblat, three-parameter Van’t Hoff, and λh), Based on the solubility data and the regression parameters of the Wilson model, the mixing thermodynamic properties (mixing Gibbs energy, mixing enthalpy, mixing entropy) as well as the activity coefficient and the reduced excess enthalpy at infinitesimal concentration were evaluated.

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Section: Thermodynamic Modelsmentioning

confidence: 99%

Solubility Determination and Thermodynamic Modeling of Amitriptyline Hydrochloride in 13 Pure Solvents at Temperatures of 283.15–323.15 K

Shi

Wang

et al. 2021

J. Chem. Eng. Data

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“…Solubility is an essential physicochemical property of APIs, and the thermodynamic models can correlate the data and widen the applicability of experimental solubility . Several equations and models can be used to correlate and predict the solid–liquid equilibrium process of organic compounds.…”

Section: Thermodynamic Modelsmentioning

confidence: 99%

Solubility Measurement and Data Correlation of Pentaerythritol in Four Binary Solvent Systems at Temperatures from 283.15 to 323.15 K

et al. 2021

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The solubility of pentaerythritol (PE) in four binary solvents (methanol + water, ethanol + water, isopropanol + water, acetonitrile + water) is determined using the gravimetric method at temperatures ranging from 283.15 to 323.15 K under 0.1 MPa. The experimental results demonstrate that the solubility of PE increases with the increase of temperature in all four binary solvent systems. And water has a relatively positive effect on the solubility of PE in all four binary solvents. However, the solubility of PE in ethanol + water and isopropanol + water mixtures first increases with the increase of the ethanol/isopropanol fraction and then decreases when the temperature exceeds 303.15 and 288.15 K, respectively. And the solubility reaches the maximum when the initial mole fractions of ethanol/isopropanol of the binary solvent are 0.2. Besides, experimental solubility is fitted with three thermodynamic models including the modified Apelblat model, λh model, and CNIBS/R-K model, and all of the average relative deviation (ARDs) are less than 4%, indicating good accordance with the experimental results. In addition, among the three thermodynamic models, the CNIBS/R-K model has the best fitting performance, in which all of the ARDs are less than 1.7%.

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“…The experimental apparatus was similar with that reported in the literatures [11,20,21]. The apparatus included a 100 mL jacketed glass vessel, a magnetic stirrer, and a circulating water system which was employed to maintain the solution temperature.…”

Section: Materials and Apparatusmentioning

confidence: 99%

Solubility determination and thermodynamic models for dehydroepiandrosterone acetate in mixed solvents of (ethyl acetate + methanol), (ethyl acetate + ethanol) and (ethyl acetate + isopropanol)

Cheng

Cong

et al. 2016

The Journal of Chemical Thermodynamics

103

128

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Determination and modeling of aqueous solubility of 4-position substituted benzoic acid compounds in a high-temperature solution

Cited by 53 publications

References 39 publications

Solubility Determination and Thermodynamic Modeling of Amitriptyline Hydrochloride in 13 Pure Solvents at Temperatures of 283.15–323.15 K

Solubility Determination and Thermodynamic Modeling of Amitriptyline Hydrochloride in 13 Pure Solvents at Temperatures of 283.15–323.15 K

Solubility Measurement and Data Correlation of Pentaerythritol in Four Binary Solvent Systems at Temperatures from 283.15 to 323.15 K

Solubility determination and thermodynamic models for dehydroepiandrosterone acetate in mixed solvents of (ethyl acetate + methanol), (ethyl acetate + ethanol) and (ethyl acetate + isopropanol)

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