Solubility determination and thermodynamic models for dehydroepiandrosterone acetate in mixed solvents of (ethyl acetate + methanol), (ethyl acetate + ethanol) and (ethyl acetate + isopropanol)

Cheng, Chao; Cong, Yang; Du, Cunbin; Jian, Wang; Yao, Ganbing; Zhao, Hongkun

doi:10.1016/j.jct.2016.06.014

Cited by 103 publications

(128 citation statements)

References 22 publications

Supporting

Mentioning

128

Contrasting

Order By: Relevance

“…The solid-liquid phase equilibrium of ACET in (acetone + methanol), (acetone + ethanol), (acetone + 1-butanol) and (acetone + isopropanol) mixtures was built at temperatures ranging from (273.15 to 323.15) K using the isothermal dissolution equilibrium method [31,32]. The content of ACTE in equilibrium with the liquid phase was determined with the high-performance liquid phase chromatograph (HPLC; Agilent Technologies, USA).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Solubility measurement and modelling of ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)-2-thiophenecarboxylate in four groups mixed solvents

Han

Zhao

2016

The Journal of Chemical Thermodynamics

Self Cite

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 99%

“…A condenser was connected to glass vessel to avoid solvent escaping. Before the experiment, the reliability of experimental apparatus was verified by determining the solubility of benzoic acid in toluene [31,32].…”

Section: Apparatusmentioning

confidence: 99%

Solubility measurement and modelling of ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)-2-thiophenecarboxylate in four groups mixed solvents

Han

Zhao

2016

The Journal of Chemical Thermodynamics

Self Cite

View full text Add to dashboard Cite

“…An analytical balance (model: BSA224S) having a standard uncertainty of 0.0001 g and provided by Satorius Scientific Instrument (Beijing) was used to determine the mass of the solute, solvent, and saturated solution. The reliability of apparatus was verified in advance by determining the benzoic acid solubility in toluene [40,41].…”

Section: Materials and Apparatusmentioning

confidence: 99%

“…In this work the solid-liquid equilibrium for ribavirin in binary solvent mixtures of (methanol + water), (n-propanol + water), (acetonitrile + water) and (1,4-dioxane + water) was determined by an isothermal dissolution equilibrium method [40][41][42][43][44][45], and the highperformance liquid phase chromatograph was employed to determine the solubility of ribavirin in equilibrium liquid phase.…”

Section: Solubility Measurementmentioning

confidence: 99%

“…[25]. In the present work, three models are used to correlate the solubility of ribavirin in binary solvent mixtures of (methanol + water), (n-propanol + water), (acetonitrile + water) and (1,4dioxane + water) at different temperatures, which correspond to JouybanÀAcree model [25,41,50], a combination of the Jouy-banÀAcree model with van't Hoff equation [41,50], and a combination of the JouybanÀAcree model with modified Apelblat equation [41,50].…”

Section: Solubility Modellingmentioning

confidence: 99%

See 1 more Smart Citation

Thermodynamic modelling of solubility and preferential solvation for ribavirin (II) in co-solvent mixtures of (methanol, n -propanol, acetonitrile or 1,4-dioxane) + water

Cong

et al. 2017

The Journal of Chemical Thermodynamics

Self Cite

View full text Add to dashboard Cite

a b s t r a c tThe equilibrium solubility of ribavirin in solvent mixtures of {methanol (1) + water (2)}, {n-propanol (1) + water (2)}, {acetonitrile (1) + water (2)} and {1,4-dioxane (1) + water (2)} was determined experimentally by using isothermal dissolution equilibrium method within the temperature range from (278.15 to 318.15) K under atmospheric pressure (101.1 kPa). At the same temperature and mass fraction of methanol (n-propanol, acetonitrile or 1,4-dioxane), the mole fraction solubility of ribavirin is greater in (methanol + water) than in the other three solvent mixtures. The preferential solvation parameters were derived from their thermodynamic solution properties by means of the inverse Kirkwood-Buff integrals. The preferential solvation parameters for methanol, n-propanol, acetonitrile or 1,4-dioxane (dx 1,3 ) were negative in the four solvent mixtures with a very wide compositions, which indicated that ribavirin was preferentially solvated by water. Temperature had little effect on the preferential solvation magnitudes. The higher solvation by water could be explained in terms of the higher acidic behaviour of water interacting with the Lewis basic groups of the ribavirin. Besides, the solubility of the drugs was mathematically represented by using the Jouyban-Acree model, van't Hoff-Jouyban-Acree model and Apelblat-Jouyban-Acree model obtaining average relative deviations lower than 1.57% for correlative studies. It is noteworthy that the solubility data presented in this work contribute to expansion of the physicochemical information about the solubility of drugs in binary solvent mixtures and also allows the thermodynamic analysis of the respective dissolution and specific solvation process.

show abstract

Selective Bioethanol Conversion to Chemicals and Fuels via Advanced Catalytic Approaches

Phung

Busca

2020

Biorefinery of Alternative Resources: Targeting Green Fuels and Platform Chemicals

View full text Add to dashboard Cite

Solubility determination and thermodynamic models for dehydroepiandrosterone acetate in mixed solvents of (ethyl acetate + methanol), (ethyl acetate + ethanol) and (ethyl acetate + isopropanol)

Cited by 103 publications

References 22 publications

Solubility measurement and modelling of ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)-2-thiophenecarboxylate in four groups mixed solvents

Solubility measurement and modelling of ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)-2-thiophenecarboxylate in four groups mixed solvents

Thermodynamic modelling of solubility and preferential solvation for ribavirin (II) in co-solvent mixtures of (methanol, n -propanol, acetonitrile or 1,4-dioxane) + water

Selective Bioethanol Conversion to Chemicals and Fuels via Advanced Catalytic Approaches

Contact Info

Product

Resources

About