Determination and Correlation of Dipyridamole p-Toluene Sulfonate Solubility in Seven Alcohol Solvents and Three Binary Solvents

Experimental solubility data of sodium naphthalene-1,5-disulfonate in five neat solvents (water, methanol, ethanol, 2-propanol, acetone) and three binary solvent systems (water + ethanol, water + 2-propanol, water + acetone) at different temperatures from 283.15 to 323.15 K were determined by the gravimetric method. The experimental results showed that three kinds of polymorphs appeared in the investigated solvent systems, and the solubility of sodium naphthalene-1,5-disulfonate all increased with increasing temperature and water content. According to the data measured, water was suitable to be the positive solvent, while methanol was considered to be a less-effective antisolvent due to its relatively large dissolving capacity. By means of our research, the solubility of sodium naphthalene-1,5-disulfonate in the neat solvents had a relation with the polarity of the solvents. The solubilities of sodium naphthalene-1,5-disulfonate were fitted by the modified Apelblat, Jouyban-Acree, van’t Hoff-Jouyban-Acree, and Apelblat-Jouyban-Acree models. The results showed that the four models can predict the experimental values very well.

Section: Resultsmentioning

confidence: 99%

Determination and Correlation of the Solubility of Sodium Naphthalene-1,5-disulfonate in Five Pure Solvents and Three Binary Solvent Systems at the Temperature Range from 283.15 to 323.15 K

Qiu

et al. 2019

“…The value of parameter C indicates the influence of temperature on the fusion enthalpy of a solute. 16 3.2. Jouyban-Acree Model.…”

Section: Thermodynamic Models and Correlationmentioning

confidence: 99%

“…The parameters A and B show the influence of solution non-ideality upon the solute solubility and the variation of solute activity coefficient, respectively. The value of parameter C indicates the influence of temperature on the fusion enthalpy of a solute …”

Section: Thermodynamic Models and Correlationmentioning

confidence: 99%

Measurement and Correlation for Solubility of l-Alanine in Pure and Binary Solvents at Temperatures from 283.15 to 323.15 K

An¹,

Qiu²,

Yi³

et al. 2020

The solubility of l-alanine in five binary systems water + methanol, water + ethanol, water + 1-propanol, water + 2-propanol, and water + acetone and 12 neat solvents (water, 1-butanol, methanol, 2-butanol, 2-methyl-1-propanol, 1-pentanol, 1-propanol, ethanol, 2-propanol, ethyl acetate, acetonitrile, and acetone) was determined by the gravimetrical method within the temperature range from 283.15 to 323.15 K under atmospheric pressure. The experimental results indicated that the solubility increased with increasing temperature and mole ratio of water in all investigated solvents and decreased with the rise of the mole fraction of five different organic solvents in the binary solvent systems. The order of l-alanine solubility in the selected pure solvents was water > 1-butanol > methanol ≈ 2-butanol > 2-methyl-1-propanol ≈ 1-pentanol ≈ 1-propanol ≈ ethanol > 2-propanol > ethyl acetate > acetonitrile > acetone. The solubility was mathematically represented by the modified Apelblat, Jouyban–Acree, and Apelblat–Jouyban–Acree models. All the models can be found to agree well with the data in the experiment.

“…In addition, solvents with a larger steric hindrance could have a lower solubility. 50 Thus, the solubility of ETCH in alcohols with straight chains is higher than that in branched alcohols. Besides, the viscosity of a solvent may also impact the solubility of a solute, and a higher value of solvent viscosity could reduce the solubility.…”

Section: Resultsmentioning

confidence: 99%

“…This can be the reason for the relatively high solubility in the solvents 1,4-dioxane and acetone. In addition, solvents with a larger steric hindrance could have a lower solubility . Thus, the solubility of ETCH in alcohols with straight chains is higher than that in branched alcohols.…”

Section: Resultsmentioning

confidence: 99%

Solubility Behavior of Ethyl l-Thiazolidine-4-carboxylate Hydrochloride in 15 Neat Solvents and Ethanol + Methyl Acetate Binary Solvent from 283.15 to 323.15 K

Qiu

Wang

et al. 2021

The solubility (mole fraction) of ethyl L-thiazolidine-4-carboxylate hydrochloride in 15 individual solvents including water, methanol, ethanol, npropanol, isopropanol, n-butanol, isobutanol, sec-butanol, acetone, 2-butanone, acetonitrile, dichloromethane, methyl acetate, ethyl acetate, and 1,4-dioxane, as well as one binary mixed solvent of ethanol + methyl acetate from 283.15 to 323.15 K was measured by a static gravimetric method. The solid phase of ethyl L-thiazolidine-4-carboxylate hydrochloride in the investigated solvent systems was characterized by the powder X-ray diffraction test. The rising temperature exhibits a positive effect on the ethyl L-thiazolidine-4-carboxylate hydrochloride solubility in pure solvents, while a cosolvency phenomenon was observed in the binary solvent. The solubility behavior in pure solvents was found to be influenced by the mutual effect of six factors including polarity, hydrogenbonding interaction, solvent−solvent interactions, molecular structures, steric effects, and solvent viscosity. In addition, the measured solubility data were fitted utilizing two thermodynamic models, i.e., the modified Apelblat model and the Apelblat−Jouyban−Acree model.