Determination and Correlation of the Solubility of Sodium Naphthalene-1,5-disulfonate in Five Pure Solvents and Three Binary Solvent Systems at the Temperature Range from 283.15 to 323.15 K

Self Cite

The mole fraction solubility data of N-acetyl-l-proline in 16 neat solvents (water, methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, sec-butanol, n-pentanol, acetone, 2-butanone, acetonitrile, dichloromethane, methyl acetate, ethyl acetate, and 1,4-dioxane) covering a temperature range of 283.15–323.15 K were measured by the static gravimetric method. The polymorphism of N-acetyl-l-proline was investigated by the powder X-ray diffraction test and the patterns show that there are two polymorphs within the studied solid–liquid equilibrium systems. The increasing temperature shows a positive effect on N-acetyl-l-proline solubility in all of the solvents and the largest increasing rate is observed in acetonitrile with an increase of 16-fold. The solubility behavior was found to be influenced by five factors including polarity, hydrogen bonding, solvent–solvent interactions, molecular construction, and viscosity. Two thermodynamic models, i.e., the modified Apelblat model and the Yaws model, were used for the correlation of solubility data. To evaluate the fitting results, the average relative deviation (ARD) and root-mean-square deviation (RMSD), as well as the Akaike information criterion (AIC) and Akaike weights, were computed for each model.

Section: Experimental Sectionsupporting

confidence: 61%

Solubility Behavior and Polymorphism of N-Acetyl-l-proline in 16 Individual Solvents from 283.15 to 323.15 K

Huang

Qiu

et al. 2021

Self Cite

“…All chemicals were used in the experiments as received without further processing. The solubility data of l -arginine l -pyroglutamate in different solvent systems were determined by the static gravimetric method, which has been described and verified in our previous studies. − The method mainly includes three steps: solid–liquid equilibrium, solid–liquid phase separation, and supernatant analysis. The detailed process for solubility determination is given in the Supporting Information.…”

Section: Methodsmentioning

confidence: 99%

“…The preweighed L-arginine L-pyroglutamate (5−6 mg) was heated from 299. 15 to 865 K at a rate of 5 K•min −1 in a nitrogen atmosphere. The pattern is shown in Figure 3.…”

Section: Methodsmentioning

confidence: 99%

Solubility Behavior and Polymorphism of l-Arginine l-Pyroglutamate in Nine Pure Solvents and a Binary Water + Ethanol System

Han

Liu

et al. 2021

Self Cite

The solubility data of L-arginine L-pyroglutamate were determined by the static gravimetric method from 283.15 to 323.15 K in nine pure solvents (water, methanol, ethanol, isopropanol, acetone, acetonitrile, dichloromethane, ethyl acetate, and n-hexane) and a water + ethanol binary solvent system. According to experimental results, solubility was positively correlated with temperature. In the selected solvent systems, three different polymorphs denoted as α-form, β-form, and γ-form were found. In addition, from the data analysis results, the polarity, hydrogen bonding, Hildebrand solubility parameters, and the molecular structure affected the dissolution equilibrium. Two thermodynamic models including the modified Apelblat model and the Yaws model were used to correlate the solubility data. Meanwhile, these models were evaluated by the Akaike information criterion method.

“…All chemicals used in this experiment were maintained in suitable storage conditions and without further treatment. The solubility data of NAM in 16 pure solvents were determined by the static gravimetric method, which has been described , and verified in detail in our previous works. − It can be summarized as the following three steps: (1) solid–liquid phase equilibrium, (2) solid–liquid phase separation, and (3) analysis of the supernatant. Also, the detailed experimental operation for the method can be seen in the Supporting Information.…”

Section: Methodsmentioning

confidence: 90%

Solubility Behavior and Polymorphism of N-Acetyl-dl-methionine in 16 Individual Solvents from 283.15 to 323.15 K

Huang

Qiu

et al. 2021

Self Cite

The mole fraction solubility data of N-acetyl-dl-methionine in 16 pure solvents at T = 283.15–323.15 K were measured using the static gravimetric method under a pressure of 98.8 kPa. The polymorphism of N-acetyl-dl-methionine was studied by X-ray powder diffraction analysis, and the results show that there may exist two polymorphs in the studied solid–liquid equilibrium systems. The solubility increased with increasing temperature, and the largest solubility value was obtained in methanol, followed by ethanol > n-propanol > isopropanol > n-butanol > sec-butanol > isobutanol > n-pentanol > acetone > 2-butanone > water > methyl acetate > ethyl acetate > dichloromethane (except for 1,4-dioxane and acetonitrile, which intersect with other solvents). The above solubility behavior is affected by the mutual constraints of polarity, hydrogen bonding, cohesive energy density, viscosity, and molecular structure. In addition, the KAT-LSER model was applied to analyze solute–solvent and solvent–solvent intermolecular interactions. To mathematically represent the measured solubility data, the modified Apelblat model and Yaws model were employed. The average relative deviation (ARD), root-mean-square deviation (RMSD), Akaike information criterion (AIC), and Akaike values of each model were calculated to evaluate the fitting outcomes.