Determination and characterization of silver nanoparticles in bivalve molluscs by ultrasound assisted enzymatic hydrolysis and sp-ICP-MS

About detectability and limits of detection in single particle inductively coupled plasma mass spectrometry

“…The expressions found in SP-ICP-MS publications for calculation of size LODs are mainly based on the use of the 3σ criterion [8,17,[26][27][28][29][30][31][32][36][37][38][39][40][41][42][44][45][46], although the use of a 5σ criterion has also been reported [33][34][35]45]. Interpretation of a 3σ criterion on basis of LOD theory must involve the consideration of both type I (false positives) and type II (false negatives) errors, where , but also 0.00135 and 0.5, where the limit of = = 0.067 = = detection is equal to the critical value ( ).…”

Analytical applications of single particle inductively coupled plasma mass spectrometry: a comprehensive and critical review

“…Reported size detection limits and size distributions allowed to confirm that nanoparticle distribution were incomplete in some cases. 246,264,266 Moreover, and although SEM and DLS were used in some studies, these techniques did not provide conclusive information, hence the studies only confirmed the occurrence of particles containing the elements detected and not their specific nature. Human body fluids and tissues.…”

“…Aquatic organisms. The analysis of aquatic organisms has included plankton, 228 crustaceans, 228 molluscs 228,246,[264][265][266] and fishes. 228 In all cases, prior to SP-ICP-MS analysis, nanoparticles were extracted by digestion of the biological matrices.…”

“…228 In all cases, prior to SP-ICP-MS analysis, nanoparticles were extracted by digestion of the biological matrices. Enzymatic digestions included the use of pancreatin/lipase, 246,264,265 whereas alkaline digestions were based on the use of TMAH. 228,266 The most studied elements have been Ti 228,246,265 and Ag, 228,246,264 although nanoparticles containing Cu, 246 Zn 246 or different rare earth elements 266 have been also considered.…”

“…Enzymatic digestions included the use of pancreatin/lipase, 246,264,265 whereas alkaline digestions were based on the use of TMAH. 228,266 The most studied elements have been Ti 228,246,265 and Ag, 228,246,264 although nanoparticles containing Cu, 246 Zn 246 or different rare earth elements 266 have been also considered. In relation to the information reported, all the articles provided quantitative information of particle mass and number concentration, particle size distribution and mean size.…”