Potential human health effects following exposure to nano- and microplastics, lessons learned from nanomaterials

Brouwer, Hugo; Oijen, Femke L.N. Van; Bouwmeester, Hans

doi:10.1016/b978-0-12-819470-6.00014-7

Cited by 6 publications

(3 citation statements)

References 130 publications

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“…Comprehensive understanding of the impact of ingested microplastics on human health remains limited (Rahman et al, 2021;Brouwer et al, 2023). It is established, however, that MP has been detected in the human population.…”

Section: Human Health Risksmentioning

confidence: 99%

Overview of Microplastics in the Meat: Occurrence, Detection Methods and Health Effects

Velebit,

Janković,

Milojević

et al. 2023

Meat Technology

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The exponentially increasing annual production of plastic waste at a global level has raised concerns regarding the prospective infiltration of microplastics into terrestrial ecosystems. The transport of microplastics via wind advection and stormwater runoff presents a substantial hazard to food resources. The most recent studies reveal that chicken, pork, and beef samples are contaminated with microplastic particles, encompassing polystyrene, polyethylene terephthalate, and polypropylene. However, the employment of various non-standardized detection methodologies poses a significant obstacle in the interpretation of acquired results. Furthermore, the thorough clarification of the correlation between human exposure to microplastics and various health consequences, such as carcinogenicity, infertility, metabolic disorders and pregnancy complications, remains inadequately explored and necessitates additional investigation to enhance public awareness and propose solutions and integrated strategies for the mitigation of microplastic contamination in meat chain.

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Section: Human Health Risksmentioning

confidence: 99%

Overview of Microplastics in the Meat: Occurrence, Detection Methods and Health Effects

Velebit,

Janković,

Milojević

et al. 2023

Meat Technology

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“…quantitative in vitro to in vivo extrapolations or QIVIVE), stem cell-based models seem to be favored as these consist of non-diseased tissue made up of the relevant cell types found in vivo. In view of replacing animal experiments, efforts have already been made to apply physiologically based kinetic (PBK) models to nanomaterials in order to extrapolate in vitro uptake data to the in vivo situation (Brouwer et al, 2023). Although the acceptance of PBK model data in a regulatory context is still limited (Lamon et al, 2019), using input data from physiologically relevant stem cell-based in vitro models might facilitate the development in this direction.…”

Section: Conclusion and Future Outlookmentioning

confidence: 99%

Investigating nanoplastics toxicity using advanced stem cell-based intestinal and lung in vitro models

et al. 2023

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Plastic particles in the nanometer range–called nanoplastics–are environmental contaminants with growing public health concern. As plastic particles are present in water, soil, air and food, human exposure via intestine and lung is unavoidable, but possible health effects are still to be elucidated. To better understand the Mode of Action of plastic particles, it is key to use experimental models that best reflect human physiology. Novel assessment methods like advanced cell models and several alternative approaches are currently used and developed in the scientific community. So far, the use of cancer cell line-based models is the standard approach regarding in vitro nanotoxicology. However, among the many advantages of the use of cancer cell lines, there are also disadvantages that might favor other approaches. In this review, we compare cell line-based models with stem cell-based in vitro models of the human intestine and lung. In the context of nanoplastics research, we highlight the advantages that come with the use of stem cells. Further, the specific challenges of testing nanoplastics in vitro are discussed. Although the use of stem cell-based models can be demanding, we conclude that, depending on the research question, stem cells in combination with advanced exposure strategies might be a more suitable approach than cancer cell lines when it comes to toxicological investigation of nanoplastics.

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“…With potential applications in industries range starting cosmetics to electronics, the area of nanotechnology and nanoscience are rapidly expanding for biological, physical, chemical, and phenomena at the sub-atomic and atomic level [1][2][3][4][5][6][7][8][9]. Scientists are working hard to discover new technologies through nanosciences and nanotechnology that are involved in the creation of new materials with distinctive and better properties [10][11][12].…”

Section: ■ Introductionmentioning

confidence: 99%

Green Synthesis and Electrochemical Study of Undoped and Doped Al2O3 Nanoparticles Using Hibiscus rosa-sinensis Leaves Extract

Haider,

Nabi,

Shah

et al. 2023

Indones. J. Chem.

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In the present work, nanoparticles of Al2O3, Cu-Al2O3, and Ni-Al2O3 were prepared using Hibiscus rosa-sinensis plant leaf extract through co-precipitation method. The prepared nanomaterials were characterized through TGA, EDX, SEM, UV-Vis, XRD, and FTIR instruments. The electrochemical behavior of Al2O3, Cu-Al2O3, and Ni-Al2O3 has been studied in DMF solution in the potential ranges from −1.5 to 1.5 V. The nanoparticles are thermally stable, according to the TGA, and the XRD patterns revealed that all the Al2O3, Cu-Al2O3, and Ni-Al2O3 particles were crystalline, with the mean sizes of 12.44, 34.61, and 31.63 nm, respectively. The cyclic voltammogram showed a cathodic peak (Epc) at 0.49 V with an anodic counterpart (Epa) at 0.49 V [E1/2 = 1.748 V]. The optical band gaps of Al2O3, Cu-Al2O3, and Ni-Al2O3 were 3.8, 3.2 and 3.65 eV, owed a cathode. It is observed that the electrochemical behavior of Ni-Al2O3 was identical to that of Al2O3 and Cu-Al2O3. The anodic and cathodic peak values rise with the scan rate. The one-electron oxidation and reduction processes are reversible, as seen by the shifting cathodic peak value toward higher negative values. All cycles exhibit absorption has a constant anodic current. This result indicated the diffusion-based redox process.

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Potential human health effects following exposure to nano- and microplastics, lessons learned from nanomaterials

Cited by 6 publications

References 130 publications

Overview of Microplastics in the Meat: Occurrence, Detection Methods and Health Effects

Overview of Microplastics in the Meat: Occurrence, Detection Methods and Health Effects

Investigating nanoplastics toxicity using advanced stem cell-based intestinal and lung in vitro models

Green Synthesis and Electrochemical Study of Undoped and Doped Al<sub>2</sub>O<sub>3</sub> Nanoparticles Using <i>Hibiscus rosa-sinensis</i> Leaves Extract

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