Determinants of volumetric breast density in Chilean premenopausal women

Pereira, Ana; Garmendia, María Luisa; Uauy, Ricardo; Neira, Paulina; López-Arana, Sandra; Malkov, Serghei; Shepherd, John

doi:10.1007/s10549-017-4126-7

Cited by 10 publications

(19 citation statements)

References 38 publications

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“…The between women associations of attained premenopausal BMI and breast density observed in this study were consistent with previous studies. High BMI is associated with high dense volume [33][34][35], but the correlation between BMI and dense area is less strong, and often close to zero [36][37][38][39]. These differences are likely to be a result of volumetric measures representing breast tissue more accurately than area-based methods by accounting for breast thickness and overlapping tissue.…”

Section: Discussionmentioning

confidence: 99%

“…These differences are likely to be a result of volumetric measures representing breast tissue more accurately than area-based methods by accounting for breast thickness and overlapping tissue. Additionally, since the breast is a deposit for adipose tissue, high attained BMI is strongly associated with high levels of breast fat area [36][37][38][39] and breast fat volume [33,34], which in turn leads to an inverse association between BMI and both percent dense area [36][37][38][39][40][41] and percent dense volume [33][34][35]42,43].…”

Section: Discussionmentioning

confidence: 99%

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The Relationship between Body Mass Index and Mammographic Density during a Premenopausal Weight Loss Intervention Study

Atakpa

Brentnall

Astley

et al. 2021

Cancers

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We evaluated the association between short-term change in body mass index (BMI) and breast density during a 1 year weight-loss intervention (Manchester, UK). We included 65 premenopausal women (35–45 years, ≥7 kg adult weight gain, family history of breast cancer). BMI and breast density (semi-automated area-based, automated volume-based) were measured at baseline, 1 year, and 2 years after study entry (1 year post intervention). Cross-sectional (between-women) and short-term change (within-women) associations between BMI and breast density were measured using repeated-measures correlation coefficients and multivariable linear mixed models. BMI was positively correlated with dense volume between-women (r = 0.41, 95%CI: 0.17, 0.61), but less so within-women (r = 0.08, 95%CI: −0.16, 0.28). There was little association with dense area (between-women r = −0.12, 95%CI: −0.38, 0.16; within-women r = 0.01, 95%CI: −0.24, 0.25). BMI and breast fat were positively correlated (volume: between r = 0.77, 95%CI: 0.69, 0.84, within r = 0.58, 95%CI: 0.36, 0.75; area: between r = 0.74, 95%CI: 0.63, 0.82, within r = 0.45, 95%CI: 0.23, 0.63). Multivariable models reported similar associations. Exploratory analysis suggested associations between BMI gain from 20 years and density measures (standard deviation change per +5 kg/m2 BMI: dense area: +0.61 (95%CI: 0.12, 1.09); fat volume: −0.31 (95%CI: −0.62, 0.00)). Short-term BMI change is likely to be positively associated with breast fat, but we found little association with dense tissue, although power was limited by small sample size.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Relationship between Body Mass Index and Mammographic Density during a Premenopausal Weight Loss Intervention Study

Atakpa

Brentnall

Astley

et al. 2021

Cancers

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“…Raw images were saved in low and high energy, and AFGV and %FGV were calculated using software from one of the investigators (Shepherd) with intra-and interrater readings all had ICC values greater than 0.9. Recently, Pereira et al found that in 200 GOCs mothers, the precision of the DXA data after the repositioning of the left breast was 2.8%, and the ICCs for %FGV and AFGV were > 0.9 19 .…”

Section: Methodsmentioning

confidence: 99%

“…One of the major difficulties is the challenge of measuring BD in young women. Recently, dual energy X-ray absorptiometry (DXA) technology has been developed for this purpose and has been shown to be valid, reproducible and accurate (precision of 2.8%) 19 with a minimal dose of radiation; therefore, DXA can be used in young women 20 . Thus, by investigating a Chilean cohort of mothers and daughters, our study aimed to assess the relation between EGWG according to the 2009 IOM guidelines 6 and BD estimated by DXA in the offspring at the end of puberty (B4).…”

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confidence: 99%

Effect of excessive gestational weight on daughters’ breast density at the end of puberty onset

Lopez

Garmendia

Shepherd

et al. 2020

Sci Rep

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The effect of excessive gestational weight gain (EGWG) is related to adverse health outcomes in the offspring; however, its effect on the daughters' breast density is unclear. We aimed to assess the association between EGWG and daughters' breast composition (% of fibroglandular volume (%FGV) and absolute fibroglandular volume (AFGV)) at Tanner stage 4 (Tanner B4)). We included 341 girls and their mothers from an ongoing cohort of low-income Chilean girls born from 2002-2003. Maternal gestational weight gain was self-reported in 2007, and breast density by digital mammography was measured in 2010. Weight, height and breast composition by dual X-ray absorptiometry (DXA) were measured in daughters at Tanner B4. Logistic regression models were run to assess the association between EGWG and the 80th percentile of %FGV and AFGV. Mean gestational weight gain was 13.7 kg (SD = 6.9 kg). Women with pregestational overweight or obesity exceeded the recommended gestational weight gain (58.8% vs. 31.8%, respectively). Daughters of women who had EGWG had higher levels of AFGV (OR: 2.02; 95%CI 1.16-3.53) at Tanner B4, which could be explained by metabolic and hormonal exposure in utero. However, we did not observe an association with %FGV.

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“…The epidemiological evidence on the association between the smoking status and breast density has been limited and inconsistent so far. Of the 15 epidemiological studies, most have evaluated the relationship with the current smoking status and found a lower mammographic density among current smokers when compared to former smokers or non-smokers [12][13][14][15][16][17][18][19][20][21][22]. The association between the lifelong smoking duration or intensity and breast density has been rarely addressed [4,[12][13][14][15].…”

Section: Questionnaire and Anthropometric Measurementsmentioning

confidence: 99%

Cigarette smoking and mammographic breast density among Polish women

Pepłońska¹,

Kałużny²

2021

Int J Occup Med Environ Health

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High mammographic breast density (MBD) is one of the strongest breast cancer risk factors. The results of some epidemiological studies suggest that one of the lifestyle factors likely altering breast density is cigarette smoking. The aim of this study was to assess the association between active smoking, considering in detail the duration and intensity of smoking, and MBD among Polish women. Material and Methods: A cross-sectional study included 467 women aged 40-60 years who underwent screening mammography in Łódź, Poland. Volumetric mammographic density, fibroglandular tissue volume and non-fibroglandular tissue volume were determined based on the analysis of mammographic image (in the "for processing" format) using Volpara Imaging Software. Current and lifetime intensity of cigarette smoking was assessed based on the data from interviews. Linear and logistic regressions were fitted with estimated MBD parameters as the outcomes, and life-long smoking duration and intensity as the determinants, adjusted for major confounders. Results: The former smokers had a significantly lower volumetric mammographic density compared to the non-smokers in the crude analysis (p = 0.022). However, the associations became insignificant after adjustments for important confounding factors. The analyses adjusted for important confounders revealed an inverse statistically significant association between the number of pack-years and volumetric mammographic density among the current smokers (p = 0.048). Conclusions: The observed result is consistent with the majority of previous studies that analyzed the associations between mammographic density and life-long smoking duration.

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Determinants of volumetric breast density in Chilean premenopausal women

Abstract: DXA is an alternative method to measure volumetric BD; thus, it could be used to continuously monitor BD in adult women in follow-up studies or to assess BD in young women.

Cited by 10 publications

References 38 publications

The Relationship between Body Mass Index and Mammographic Density during a Premenopausal Weight Loss Intervention Study

The Relationship between Body Mass Index and Mammographic Density during a Premenopausal Weight Loss Intervention Study

Effect of excessive gestational weight on daughters’ breast density at the end of puberty onset

Cigarette smoking and mammographic breast density among Polish women

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