Determinants of use of oral complementary-alternative medicine among women with early breast cancer: a focus on cancer-related fatigue

Lapidari, Pietro; Djehal, Nardjes; Havas, Julie; Gbenou, Arnauld; Martin, Élise; Dauchy, Sarah; Pistilli, Barbara; Cadeau, Claire; Bertaut, Aurélie; Everhard, Sibille; Martin, Anne‐Laure; Coutant, Charles; Cottu, Paul; Menvielle, Gwenn; Dumas, Agnès; André, Fabrice; Michiels, Stefan; Vaz-Luís, Inês; Meglio, Antonio Di

doi:10.1007/s10549-021-06394-2

Cited by 13 publications

(8 citation statements)

References 56 publications

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“…At this time, there are many studies that examine the effect of dietary supplements, such as probiotics [ 46 , 47 ], B-complex multivitamin/mineral supplementation [ 48 ], magnesium [ 49 ], and omega-3 [ 50 ] for anxiety, but there are few reports on whether anxiety towards health encourages people to use dietary supplements. Anxiety was associated with dietary supplement/complementary alternative medicine in cancer survivors [ 51 ], women with early breast cancer [ 52 ], and patients with liver disease [ 53 ] but not healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

Differences in the Perception of Dietary Supplements between Dietary Supplement/Medicine Users and Non-Users

Chiba¹,

Tanemura²

2022

Nutrients

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Some patients use dietary supplements and medicines concomitantly, with an inappropriate perception of their safety and efficacy. To clarify the perception between dietary supplement and medicine users and non-users, we conducted an internet survey. In this survey, 38.9% of participants used dietary supplements, 32.6% used prescription medicines, and 14.7% used dietary supplements and prescription medicines concomitantly. Then, we conducted a further survey on four groups, dietary supplement and prescription medicine users, dietary supplement only users, prescription medicine only users, and non-users (500 each). Dietary supplement users had favorable outcomes in terms of both the safety and efficacy of dietary supplements compared to dietary supplement non-users. This perception of dietary supplements was independent from medicine use. The awareness of the Health Food Network consumer navigation site, which provides information about dietary supplements for consumers, was the highest among dietary supplement and prescription medicine users, but it was still low (2.2%). In conclusion, consumers who use dietary supplement and prescription medicine concomitantly have favorable outcomes for their safety and efficacy and a low awareness of their interaction. There is a need to provide information, especially regarding the risk of interaction, that takes into account the consumer’s situation.

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Section: Discussionmentioning

confidence: 99%

Differences in the Perception of Dietary Supplements between Dietary Supplement/Medicine Users and Non-Users

Chiba¹,

Tanemura²

2022

Nutrients

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“…However, a longitudinal study among colorectal cancer survivors showed no differences in fatigue between dietary supplement users (predominately multivitamins) and nonusers [ 108 ]. In contrast, the use of oral complementary and alternative medicine (OCAM), defined as taking homeopathy, vitamins/minerals, or herbal/dietary supplements, was associated with more severe CRF in stage I–III breast cancer survivors [ 110 ].…”

Section: Dietary Recommendations For Cancer-related Fatiguementioning

confidence: 99%

A Molecular Approach to Understanding the Role of Diet in Cancer-Related Fatigue: Challenges and Future Opportunities

et al. 2022

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Cancer-related fatigue (CRF) is considered one of the most frequent and distressing symptoms for cancer survivors. Despite its high prevalence, factors that predispose, precipitate, and perpetuate CRF are poorly understood. Emerging research focuses on cancer and treatment-related nutritional complications, changes in body composition, and nutritional deficiencies that can compound CRF. Nutritional metabolomics, the novel study of diet-related metabolites in cells, tissues, and biofluids, offers a promising tool to further address these research gaps. In this position paper, we examine CRF risk factors, summarize metabolomics studies of CRF, outline dietary recommendations for the prevention and management of CRF in cancer survivorship, and identify knowledge gaps and challenges in applying nutritional metabolomics to understand dietary contributions to CRF over the cancer survivorship trajectory.

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“…In fact, at least 43% of patients take nutritional supplements during treatment, despite evidence that some supplements (e.g., antioxidants) are associated with an increased risk of recurrence and poorer survival [ 14 ]. Moreover, “oral complementary and alternative medicine,” defined as taking homeopathy, vitamins/minerals, herbal supplements, or other dietary supplements, was associated with worse cancer-related fatigue during cancer treatment [ 15 ]. Other pleiotropic behavioral interventions such as exercise and cognitive behavioral therapy are the most effective interventions available to combat cancer-related fatigue and are more effective than available pharmaceutical interventions [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

The Effects of a Mediterranean Diet Intervention on Cancer-Related Fatigue for Patients Undergoing Chemotherapy: A Pilot Randomized Controlled Trial

Kleckner

Reschke

Kleckner

et al. 2022

Cancers

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Cancer-related fatigue is a common, burdensome symptom of cancer and a side-effect of chemotherapy. While a Mediterranean Diet (MedDiet) promotes energy metabolism and overall health, its effects on cancer-related fatigue remain unknown. In a randomized controlled trial, we evaluated a rigorous MedDiet intervention for feasibility and safety as well as preliminary effects on cancer-related fatigue and metabolism compared to usual care. Participants had stage I–III cancer and at least six weeks of chemotherapy scheduled. After baseline assessments, randomization occurred 2:1, MedDiet:usual care. Measures were collected at baseline, week 4, and week 8 including MedDiet adherence (score 0–14), dietary intake, and blood-based metabolic measures. Mitochondrial respiration from freshly isolated T cells was measured at baseline and four weeks. Participants (n = 33) were 51.0 ± 14.6 years old, 94% were female, and 91% were being treated for breast cancer. The study was feasible, with 100% completing the study and >70% increasing their MedDiet adherence at four and eight weeks compared to baseline. Overall, the MedDiet intervention vs. usual care had a small-moderate effect on change in fatigue at weeks 4 and 8 (ES = 0.31, 0.25, respectively). For those with a baseline MedDiet score <5 (n = 21), the MedDiet intervention had a moderate-large effect of 0.67 and 0.48 at weeks 4 and 8, respectively. The MedDiet did not affect blood-based lipids, though it had a beneficial effect on fructosamine (ES = −0.55). Fatigue was associated with mitochondrial dysfunction including lower basal respiration, maximal respiration, and spare capacity (p < 0.05 for FACIT-F fatigue subscale and BFI, usual fatigue). In conclusion, the MedDiet was feasible and attenuated cancer-related fatigue among patients undergoing chemotherapy, especially those with lower MedDiet scores at baseline.

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Determinants of use of oral complementary-alternative medicine among women with early breast cancer: a focus on cancer-related fatigue

Cited by 13 publications

References 56 publications

Differences in the Perception of Dietary Supplements between Dietary Supplement/Medicine Users and Non-Users

Differences in the Perception of Dietary Supplements between Dietary Supplement/Medicine Users and Non-Users

A Molecular Approach to Understanding the Role of Diet in Cancer-Related Fatigue: Challenges and Future Opportunities

The Effects of a Mediterranean Diet Intervention on Cancer-Related Fatigue for Patients Undergoing Chemotherapy: A Pilot Randomized Controlled Trial

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