Determinants of uncontrolled dyslipidaemia among adult type 2 diabetes in Malaysia: The Malaysian Diabetes Registry 2009

Abstract

Numerous studies with compelling evidence had shown a clear relationship between dyslipidaemia and cardiovascular (CV) events in patients with diabetes mellitus. This was an observational study based on secondary data from the online registry database Adult Diabetes Control and Management (ADCM) looking into the determinants of uncontrolled dyslipidaemia in type 2 diabetes mellitus patients. Independent predictors were identified using multivariate logistic regression. A total of 303 centres (289 health clinics, 14 hospitals) contributed a total of 70,889 patients (1972 or 2.8% patients were from hospital). About thirty eight percent were reported to have dyslipidaemia. There were 40.7% patients on lipid-lowering agents and of those above age 40 years old, only 38.1% of them were on a statin. Malay ethnicity and younger age groups (<50 years old) were two major determinants of uncontrolled LDL-C, TG and HDL-C. Female gender and uncontrolled blood pressure were determinants of uncontrolled LDL-C, and poor glycaemic control was related independently to high TG. This study has highlighted the suboptimal management of diabetic dyslipidaemia in Malaysia. Pharmacological treatment of dyslipidaemia could be more effective. Healthcare stakeholders in this country, especially in the primary care, have to recognize these shortfalls and take immediate remedial measures.

LIPID PROFILE PATTERNS AND ASSOCIATION BETWEEN GLYCATED HAEMOGLOBIN (HbA1C) AND ATHEROGENIC INDEX OF PLASMA (AIP) IN DIABETES PATIENTS AT A TERTIARY CARE HOSPITAL IN MALAYSIA

“…Reduced HDL was observed in 25% patients. These results are supported by the previous studies that demonstrated lipid abnormalities in diabetes patients [27,19,29,16]. As shown in table 2, TC and LDL values were higher in the highrisk category than low/medium risk category although the difference was not statistically significant (p = 0.42).…”

“…Previously, Davis et al and Zhang et al found important ethnic differences in lipid profiles of diabetes patients, their results showed distinct patterns of lipid profiles amongst various ethnicities [23,24]. In the past, Malaysian studies showed mixed results with some studies showing no significant ethnic preference for dyslipidemia in diabetes patients [25,26] and others reporting a significant preference [27,28]. Regarding AIP, studies that evaluate the AIP amongst Malaysian ethnicities are unavailable for comparison due to paucity of data.…”

Vascular Disease in Young Indians (20-40 years): Role of Dyslipidemia

“…Young individuals with type 2 diabetes mellitus are often inadequately treated for risk-factors like Dyslipidemia [35]. In Malaysian adults, Chew et al, observed that young age was the major determinant of uncontrolled lipids [36].…”

Transcultural Diabetes Nutrition Algorithm: A Malaysian Application

“…The ADCM also revealed that as many as 38% of the patients with T2D in Malaysia suffer from concomitant dyslipidemia [47]. Malays were more likely to have uncontrolled low-density lipoprotein cholesterol (LDL-C) and triglycerides compared with Chinese and Indians; however, Indians were twice as likely to have inadequate high-density lipoprotein cholesterol compared with Malays [47].…”