LIPID PROFILE PATTERNS AND ASSOCIATION BETWEEN GLYCATED HAEMOGLOBIN (HbA1C) AND ATHEROGENIC INDEX OF PLASMA (AIP) IN DIABETES PATIENTS AT A TERTIARY CARE HOSPITAL IN MALAYSIA

Abstract

Objective: There is lack of data regarding lipid patterns and the relationship of the atherogenic index of plasma (AIP with glycemic control in Malaysian diabetes patients. This study aimed to assess the lipid patterns and association of AIP with HbA1c in diabetes patients at a tertiary care hospital in Malaysia. Methods:The study was conducted on 72 diabetes patients who were randomly chosen and agreed to participate in the study. AIP values were calculated using log triglycerides/high-density lipoprotein (TG/HDL) ratio. Data were analysed using SPSS 23.Results: Mean age and body mass index (BMI) of the participants were 56.88±8.89 (years) and 28.81±4.78 (kg/m 2 ) respectively. Hypercholesterolemia, hypertriglyceridemia, high low-density lipoprotein (LDL) values were found in 55.5 %, 41.7 %, 45.5 % of total participants respectively and less than desirable HDL values were observed in 25% of total participants. Overall, 37.5% patients were categorised into high-risk AIP category. BMI categories had a significant association with AIP category (p = 0.05). There was a significant positive correlation of AIP with HbA1c (r = 0.34; p = 0.0 04). HDL was negatively correlated with AIP (r = 0.27; p = 0.02). Duration of diabetes and ethnicity showed no significant association with AIP risk values. Conclusion:Diabetes patients in this study exhibited significant lipid abnormalities with increased AIP. AIP was significantly correlated with HbA1c.

High Sensitive C-Reactive Protein and Its Relationship With Other Cardiovascular Risk Variables in Obese, Overweight and Healthy Individuals

“…The findings of this study can provide baseline data for monitoring the effectiveness of national programs for the prevention and control of obesity in Malaysia [21]. Dutta et al found that overweight patients significantly took dominance in a low-risk category and there was no significant correlation between AIP, TC, HDL, LDL, TG, and BMI [22].…”

Carotid Artery Intima-Media Thickness and 10-Year Risk of Heart Disease in Diabetic Patients: A Comparative Study

“…One study reported an increase of one BMI unit caused a 0.009 mm increase in CIMT and an increase of 1 year in age caused a 0.011 mm increase in CIMT in their study [23]. Butt et al [25] reported that overweight patients significantly took dominance in a low-risk category and he did not found a significant correlation between HDL, LDL, TC, TG, and BMI.…”

Correlation of Non-High-Density Lipoprotein Cholesterol With Lipoprotein(a) in Diabetic Patients

“…According to a study conducted in Malaysia, lipid abnormalities are frequently found in diabetes patients and are associated with increased risk of CHD [18].…”