Determinants of the Blood Lead Level of US Women of Reproductive Age

Lee, Mi-Gyung; Chun, Ock K.; Song, Won O.

doi:10.1080/07315724.2005.10719436

Cited by 67 publications

(59 citation statements)

References 37 publications

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“…The absolute increase in BPb levels was only 2.1±3.9 mg/dl for the women with severe weight loss in this study with a final value of about 4 mg/dl. Lead exposure at an earlier age has been shown to increase the body Pb burden in humans (Lee et al, 2005) and rats (Han et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Blood lead levels and bone turnover with weight reduction in women

Riedt

Buckley

Brolin

et al. 2008

J Expo Sci Environ Epidemiol

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High bone turnover states are known to raise blood lead levels (BPb). Caloric restriction will increase bone turnover, yet it remains unknown if weight reduction increases BPb due to mobilization of skeletal stores. We measured whole blood Pb levels ( 206 Pb) by inductively coupled plasma mass spectrometry in 73 women (age 24-75 years; BMI 23-61 kg/m 2 ) before and after 6 months of severe weight loss (S-WL), moderate weight loss (M-WL), or weight maintenance (WM). Baseline BPb levels were relatively low at 0.2-6.0 mg/dl, and directly associated with age (r ¼ 0.49, Po0.0001). After severe WL (À37.4 ± 9.3 kg, n ¼ 17), BPb increased by 2.1 ± 3.9 mg/dl (Po0.05), resulting in BPb levels of 1.3-12.5 mg/dl. M-WL (À5.6 ± 2.7 kg, n ¼ 39) and WM (0.3±1.3 kg, n ¼ 17) did not result in an increase in BPb levels (0.5±3.2 and 0.0±0.7 mg/dl, M-WL and WM, respectively). BPb levels increased more with greater WL (r ¼ 0.24, Po0.05). Bone turnover markers increased only with severe WL and were directly correlated with WL. At baseline, higher calcium intake was associated with lower BPb (r ¼ À0.273, Po0.02), however, this association was no longer present after 6 months. Severe weight reduction in obese women increases skeletal bone mobilization and BPb, but values remain well below levels defined as Pb overexposure.

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Section: Discussionmentioning

confidence: 99%

Blood lead levels and bone turnover with weight reduction in women

Riedt

Buckley

Brolin

et al. 2008

J Expo Sci Environ Epidemiol

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“…More importantly, folate deficient children are more susceptible to intellectual impairment by Pb (Lee et al, 2005). These studies suggest folate supplementation might offer some protective effects against Pb exposure.…”

Section: Introductionmentioning

confidence: 87%

“…Cardiac blood was collected for measurement of Pb levels, which was measured using graphite furnace atom absorption spectrometry (Lee et al, 2005).…”

Section: Blood Pb Level Measurementmentioning

confidence: 99%

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Protective effects of folic acid against central nervous system neurotoxicity induced by lead exposure in rat pups

Fs¹,

Yu²,

Gao³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Recent studies found folic acid is associated with lower blood lead (Pb) levels, and folate deficient children are more susceptible to the negative cognitive effects of Pb. This study evaluated the protective effects of folate supplementation against Pb exposure in rat pups and the mechanisms of protection. A total of 72 rats were used. Thirty were administered Pb only; 30, Pb and folic acid at the same time; and 12, only physiological saline. Protective effects of folic acid were examined at 14, 21, and 28 days after treatment. Lower blood Pb levels were found in all of the samples collected from the rats treated with folic acid. Downregulation of Bc1-2 expression and upregulation of Bax expression were observed in the neurons of folic acid-treated rats. Significantly more hematoxylin and eosin stained neurons were found in the folic acid treatment group. Nuclear enrichment and neuron apoptosis were observed by electron microscopy in the Pb-treated group. In conclusion, this study demonstrated that folic acid supplementation might offer efficient protective effects against Pb poisoning in rat pups, which was associated with less neuron damage and lower blood levels of Pb.

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“…Women of Childbearing Age Lee et al (2005) studied determinants of blood lead in U.S. women of childbearing age using data from NHANES III (1988-1994 …”

Section: Epidemiology Of Blood Lead Levels In U S Womenmentioning

confidence: 99%