Protective effects of folic acid against central nervous system neurotoxicity induced by lead exposure in rat pups

Fs, Quan; Yu, Xiang; Gao, Youhe; Wz, Ren

doi:10.4238/2015.october.16.13

Cited by 9 publications

(5 citation statements)

References 11 publications

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“…After reviewing the published articles, a few studies explored the association between lead or cadmium and folate. In animal model, folic acid supplementation seemed to have potentially protective effects against lead exposure in rat pups 12 . In a multicenter prospective Korean study, containing 2171 participants, serum folate levels in pregnant women were reversely associated with blood cadmium concentrations during late pregnancy 13 .…”

Section: Discussionmentioning

confidence: 94%

Detrimental health relationship between blood lead and cadmium and the red blood cell folate level

Wang

Chen

2022

Sci Rep

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Increasing studies have demonstrated the association between heavy metal pollution and micronutrients, especially folate. However, the relationship between cadmium and folate remains rarely discussed. In this study, we aim to explore the potential correlation between cadmium and folate in human population and highlight the possible mechanism of cadmium impacting human health. We utilized the National Health and Nutrition Examination Survey (NHANES) 2017–2018 data with 5690 participants in this study. Multivariable linear regression models were adopted to investigate the serum lead and cadmium levels and RBC folate concentration. A significant reverse relationship was found between serum lead and cadmium and RBC folate. A negative relationship between serum lead and cadmium levels and the levels of RBC folate in the U.S. adult population was found in this study. Nevertheless, due to the general limitations of the NHANES data, as a cross-sectional study, a further prospective investigation is needed to discover the causality of lead and cadmium in folate status and to determine whether the folate supplement has a beneficial influence against heavy metal toxicities.

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Section: Discussionmentioning

confidence: 94%

Detrimental health relationship between blood lead and cadmium and the red blood cell folate level

Wang

Chen

2022

Sci Rep

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“…Some mechanisms can be implicated in this protective effect. FA has been demonstrated to exert an antiapoptotic role, acting directly in the mitochondrial permeability transitions and decreasing pro‐apoptotic proteins expression (Majumdar et al., 2012; Quan et al., 2015). It has also been demonstrated that this vitamin has antioxidant properties.…”

Section: Discussionmentioning

confidence: 99%

High gestational folic acid supplementation prevents hypoxia‐ischemia‐induced caspase‐3 augmenting without changing synapsin and H3 methylation levels in the rat hippocampus

Deniz

Confortim

Miguel

et al. 2021

Intl J of Devlp Neuroscience

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Perinatal asphyxia is a peripartum event that can cause permanent sequelae to the newborns, affecting the brain development. Recently, it has been demonstrated that epigenetics mechanisms play an important role in this injury and that folic acid (FA) supplementation during pregnancy can affect these epigenetics modifications as well as gene expression. We have identified both positive and negative effects of FA treatment in rats submitted to a model of neonatal hypoxia‐ischemia (HI). Considering that FA supplementation is already used in pregnant women and that HI occurs in the peripartum period, this study was designated to evaluate how gestational FA supplementation and neonatal HI affect: apoptosis (caspase‐3) and expression of synaptic proteins (synapsin and PSD‐95) and the methylation of histone H3 lysine (K) 4 and 27 in the rat hippocampus. Pregnant Wistar rats were divided according to the diets: standard (SD), supplemented with 2 mg/kg of FA or with 20 mg/kg of FA. HI procedure was performed at the 7th PND. Protein expression and H3 methylation were evaluated at the 60th PND in the rats’ hippocampus. Neonatal HI increased caspase‐3 expression decreased synapsin expression and reduced H3K4me2, ‐me3 and H3K27me2, ‐me3 in the ipsilateral hippocampus. FA only prevented the augment in caspase‐3 expression. In conclusion, neonatal HI caused lasting effects on caspase‐3‐mediated cell death (prevented by the FA) and synaptic proteins in the rats’ hippocampus. This is the first study to show that histone modifications may contribute to these pathological findings in the hippocampus of HI animals.

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“…Furthermore, FA reduced the testicular lead accumulation when compared with Lead group. Binding of lead by FA and its increased excretion (Quan et al 2015) can underlie this effect and contribute to the protective effect of folic acid.…”

Section: Discussionmentioning

confidence: 99%

“…Dietary FA deficiency acts as a predisposing factor in increasing the susceptibility for lead intoxication (Rader et al 1982). Up to our knowledge, there is one available literature about the combating effects of this therapeutic agent against neurotoxicity induced by lead exposure in rat pups (Quan et al 2015). Therefore, the mission of this study is to shed light on the potential protective role of FA on lead-induced testicular dysfunction in rat and its possible underlying mechanistic pathways.…”

Section: Introductionmentioning

confidence: 98%

The protective role of folic acid against testicular dysfunction in lead-intoxicated rat model

Gomaa¹,

Khalil²,

Abdel-Ghani³

2017

gpb

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There is an increasing concern over male reproductive toxicity caused by lead exposure. Folic acid (FA) is supposed to be a promising therapeutic strategy against lead toxicity. Therefore, the aim of this experimental study was to shed light on the potential protective role of FA on lead-induced testicular dysfunction in rats and its possible underlying mechanistic pathways. Rats (n = 24) were divided into four groups: Control, FA, Lead, and FA+Lead group. After 4 weeks, lead intoxication resulted in a marked reduction in the relative testicular weight and the serum level of testosterone, an impairment in the characters of semen analysis, and an increased content of lead, malondialdehyde and both interleukin-6 and -10 and a decreased antioxidant enzyme levels in the testicular tissue homogenate. Furthermore, marked degenerative histological changes and an increased expression of NF-κB were also noticed in the testicular tissue of Lead group. Supplementation of FA in association with lead considerably alleviated these adverse outcome responses most probably owing to its cytoprotective ability as emerged from combating the oxidative stress and inflammatory reactions. We concluded that FA could act as a highly effective fighting approach against lead-associated testicular toxicity.

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Protective effects of folic acid against central nervous system neurotoxicity induced by lead exposure in rat pups

Cited by 9 publications

References 11 publications

Detrimental health relationship between blood lead and cadmium and the red blood cell folate level

Detrimental health relationship between blood lead and cadmium and the red blood cell folate level

High gestational folic acid supplementation prevents hypoxia‐ischemia‐induced caspase‐3 augmenting without changing synapsin and H3 methylation levels in the rat hippocampus

The protective role of folic acid against testicular dysfunction in lead-intoxicated rat model

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