Determinants of syphilis infection among pregnant women attending antenatal care in hospitals of Wolaita zone, Southern Ethiopia, 2020

Lendado, Tigabu Addisu; Tekle, Tessema; Dawit, Desalegn; Binu, Wakgari; Diro, Chala Wegi; Alemayehu, Mihiretu; Tekle, Tadese

doi:10.1371/journal.pone.0269473

Cited by 5 publications

(7 citation statements)

References 35 publications

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“…Among those who had multiple sexual partners, 46.7% were found to have syphilis infection. Our findings are consistent with the studies done in northwest and southern Ethiopia [ 17 , 18 ]. Inconsistence was with the study done in Brazil [ 19 ] and the one done in Cameroon [ 11 ].…”

Section: Discussionsupporting

confidence: 94%

Prevalence and Factors Associated with Syphilis among Mothers with Missed Opportunities for Antenatal Syphilis Testing in Rural Western Uganda: A Cross-Sectional Study

Hakizimana,

Muhumuza,

Selamo

et al. 2023

International Journal of Reproductive Medicine

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Background. Early prenatal syphilis testing and treatment are essential preventative measures for maternal syphilis and associated adverse pregnancy outcomes of pregnancy; however, data shows that two-thirds of all cases are missed among women who visit prenatal care center at least once but are not tested for syphilis. This study determined the prevalence and factors associated with syphilis infection among mothers with missed opportunities for antenatal syphilis testing in rural western Uganda delivered at Fort Portal Regional Referral Hospital (FRRH). Methods. A cross-sectional study was done during the period from April 2022 to June 2022. A total of 124 participants had been recruited consecutively from postnatal ward of FRRH. Pretested questionnaires were used to obtain information on data required for analysis. Venous blood sampling (2 ml taken from the forearm using anticoagulant free vacutainer) was done for all mothers who missed opportunity for prenatal syphilis testing using both RPR and TPHA. Descriptive statistics followed by binary logistic regression analysis was done using SPSS version 22.0. Results. The prevalence of syphilis infection was 27 (21.8%). After adjusted analysis, having more than one sexual partners in the past one year was associated with higher odds of syphilis infection ( aOR = 24.922 , 95% CI: 4.462-139.201, p < 0.001 ), and staying with the partner was found to be associated with lower odds of syphilis infection ( aOR = 0.213 , 95% CI: 0.040-1.142, p = 0.050 ). Conclusions. The study identified high prevalence of syphilis infection among mothers with missed opportunities for antenatal syphilis testing, and this was positively associated with having more than one sexual partners in the past one year and negatively associated with not staying with partner.

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Section: Discussionsupporting

confidence: 94%

Prevalence and Factors Associated with Syphilis among Mothers with Missed Opportunities for Antenatal Syphilis Testing in Rural Western Uganda: A Cross-Sectional Study

Hakizimana,

Muhumuza,

Selamo

et al. 2023

International Journal of Reproductive Medicine

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“…All women in the case group were treated during pregnancy, childbirth, or puerperium. The therapeutic schemes are described below: 78% (46) benzathine benzylpenicillin 2.4 million international units administered in three-doses; 1.7% (01) benzathine benzylpenicillin 2.4 million international units administered as a single-dose; 3.4% (02) doxycycline 100 mg in postpartum women due to penicillin allergy (reactive result occurred at delivery or puerperium) and 18.6% ( 11 ) had no details of the therapeutic scheme or number of doses. In the case group, 84.7% ( n = 50) had newborns diagnosed with CS.…”

Section: Resultsmentioning

confidence: 99%

“…Previous studies have reported that risk factors for GS are: one to three PNC visits (8), less education, a history of abortion (9,10), previous sexually transmitted infections (8,10,11), multiple sex partners (9)(10)(11), unmarried status, travel of sex partner in the past 12 months (10), substance use (11). However, only one case-control study has assessed programmatic (access and quality of prenatal care) factors (8).…”

Section: Introductionmentioning

confidence: 99%

“…There has been no study to identify programmatic factors, sociodemographic, obstetric, and behavioral factors associated with GS among postpartum women with access to PNC in areas affected by social inequality (8)(9)(10)(11). Therefore, identifying whether the access to a PNC program and an adequate number of PNC visits are capable of mitigating these factors is important for preventing mother-to-child transmission of syphilis (12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

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Determinants of gestational syphilis among women attending prenatal care programs in the Brazilian Amazon

Uchôa

Araújo

Silva

et al. 2022

Front. Public Health

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BackgroundThere was a high proportion of pregnant women who were attending prenatal care who were not tested for syphilis or tested but not treated, among priority countries. The coverage for prenatal care visits, syphilis screening, and treatment are priority indicators for monitoring of the elimination of syphilis. The aim was to determine the factors associated with gestational syphilis among postpartum women who were in a prenatal care program in the Brazilian Amazon.MethodsAn unmatched case–control study was conducted at the hospital in Brazil. Data collection was carried out from November 2020 to July 2021 during hospitalization using a pretested structured questionnaire. The criteria for selection of cases and control followed the guidelines established by the Ministry of Health of Brazil; postpartum women with a laboratory diagnosis based on treponemal and/or nontreponemal tests, symptoms of syphilis or asymptomatic, treatment or not treated, and in a prenatal care program. Gestational syphilis cases were identified as women who tested positive for syphilis, and those who tested negative were controls, at minimally one prenatal care visit, childbirth, and/or the puerperium. The sample size encompassed 59 cases and 118 controls (1: 2 ratio of cases to controls). Data were analyzed using Minitab 20® and BioEstat 5.3® software. The odds ratio was calculated by multiple logistic regression.ResultsOne hundred and seventy-seven postpartum women were included in the study, 59 cases and 118 controls. Among all participants, 95.5% (169) were tested for syphilis in any trimester during pregnancy and at the delivery and 4.5% (8) were tested in the maternity only, at the time childbirth and/or puerperium. The final multiple logistic regression model evidenced that cases had higher odds compared to controls if they had past history of sexually transmitted infections (AOR: 55.4; p: 0.00), difficulty talking about condom use with their sexual partner (AOR: 4.92; p: 0.01), one to six prenatal care visits (AOR: 4.93; p: 0.01), had not received a sexually transmitted infections test result in the maternity hospital (AOR: 4.09; p: 0.04), lower monthly income (AOR: 4.32; p: 0.04), or one to three miscarriages (AOR: 4.34; p: 0.01).ConclusionThe sociodemographic, programmatic, obstetric, and sexual factors are associated with gestational syphilis among postpartum women.

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“…("Syphilis in Pregnancy," 2022). The spirochete Treponema palladium causes the widespread sexually transmitted illness known as syphilis (Lendado et al, 2022). Although this illness is typically thought to be sexually transmitted, it can also infrequently spread through blood transfusions, non-sexual contact, and even in utero (Wubete et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Syphilis among Pregnant Women Attending Antenatal Care in Yaqshiid District, Mogadishu, Somalia

Sharif Ali,

Hussein Elmi

2024

Tanzania J Hlth Res

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Background: The prevalence of syphilis among pregnant women in Somalia has been poorly studied, despite its significant impact on maternal and fetal health. In Somalia, the last syphilis study was conducted approximately 30 years ago, leaving a critical knowledge gap regarding the current epidemic of syphilis among pregnant women. Materials and methods: From January 2023 to April 2023, a hospital-based cross-sectional study was conducted on maternal and child health. A total of 300 pregnant women were included in the study, and the seroprevalence of syphilis was determined using the Venereal Disease Research Laboratory. This one-step quick diagnostic test cassette was used as the preliminary screening tool, and Positive results were confirmed using the full chemiluminescence immunoassay (CLIA) analyzer MAGLUMI. A structured questionnaire was used to collect demographic characteristics and knowledge regarding syphilis transmission and mother-to-child transmission. SPSS Version 27.0 was used to analyze the gathered data. Statistical significance was set at p < 0.05. Results: Overall, 5.3% (16/300) of pregnant women had syphilis seroprevalence. Seroprevalence rates were higher in women aged 24-34 (50.0%). There were significant relationships between syphilis infection and education (p < 0.000), occupation (p < 0.000), and residence (p = 0.002). Furthermore, a significant majority of pregnant women (78%) were unaware of syphilis transmission routes and its correlation to HIV risk (81.7%). Stillbirths constituted 23.3% of pregnancy-related problems, whereas 17% of pregnant women had a prior record of blood transfusions. Conclusions: The study found an alarming syphilis seroprevalence in pregnant women, especially in certain demographic groups. The lack of knowledge of syphilis transmission and its effects highlights the necessity for targeted education. Improved prenatal care, health awareness, and effective prevention should lessen the effects of syphilis on mother and newborn health.

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Determinants of syphilis infection among pregnant women attending antenatal care in hospitals of Wolaita zone, Southern Ethiopia, 2020

Cited by 5 publications

References 35 publications

Prevalence and Factors Associated with Syphilis among Mothers with Missed Opportunities for Antenatal Syphilis Testing in Rural Western Uganda: A Cross-Sectional Study

Prevalence and Factors Associated with Syphilis among Mothers with Missed Opportunities for Antenatal Syphilis Testing in Rural Western Uganda: A Cross-Sectional Study

Determinants of gestational syphilis among women attending prenatal care programs in the Brazilian Amazon

Seroprevalence of Syphilis among Pregnant Women Attending Antenatal Care in Yaqshiid District, Mogadishu, Somalia

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