Determinants of stakeholders’ attitudes to xenotransplantation

Amin, Latifah; Hashim, Hasrizul; Mahadi, Zurina; Ngah, Anisah Che; Ismail, Khaidzir

doi:10.1111/xen.12430

Cited by 19 publications

(30 citation statements)

References 36 publications

(109 reference statements)

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“…Third, the lack of any standardized approach to questioning respondents regarding their opinions. For example, of the final eight articles included in the meta‐analysis, religiosity was addressed from several different perspectives: (a) one series of articles asked whether the participant was Catholic, non‐Catholic, or other ; (b) one article included four items pertaining to religiosity and moral concerns that were measured on a seven‐point Likert scale ; (c) one article used a standardized religious fundamentalism scale ; while (d) another group coded religion as yes or no without showing the form of the questionnaire item (ie, how the question was asked) . A bigger concern about the questions asked revolves around genetic engineering.…”

Section: Discussionmentioning

confidence: 99%

“…Preliminary review of the 19 studies being considered, presented with considerable independent variable heterogeneity, and exhibited significant variability in the questions asked . However, the majority reported that, among those surveyed, >50% supported XTx, with a range from as low of 37% to a maximum of 83% . Of the 19 data‐based studies, 12 were considered for inclusion in our study, but only eight provided original data in a usable format for meta‐analysis .…”

Section: Methodsmentioning

confidence: 99%

“…However, the majority reported that, among those surveyed, >50% supported XTx, with a range from as low of 37% to a maximum of 83% . Of the 19 data‐based studies, 12 were considered for inclusion in our study, but only eight provided original data in a usable format for meta‐analysis . Two of the 12 articles were excluded because the data were very similar to attitudes toward xenotransplantation in other articles.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Meta‐analysis of public perception toward xenotransplantation

Mitchell

Lipps

Padilla

et al. 2020

Xenotransplantation

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The shortage of donor organs for transplantation is an international problem. One promising option to meet the need is xenotransplantation (XTx; eg, pig‐to‐human). However, there are still questions surrounding XTx that must be answered before proceeding to clinical trials. The current work is a meta‐analysis of articles published between 1985 and 2019 to analyze the factors most strongly associated with agreement and opposition toward the procedure. Although 80% (41/51) of the published studies were related to the opinions of patients, only three provided sufficient data for analysis. Thus, the bulk of what we really know about attitudes toward XTx comes from students, stakeholders, and hospital staff. The findings suggest that, before proceeding from the laboratory to clinical trials, more directed research is necessary from individual programs to achieve sufficient understanding of the attitudes of patients and the broader public, and the level of risk that is acceptable to these groups.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Meta‐analysis of public perception toward xenotransplantation

Mitchell

Lipps

Padilla

et al. 2020

Xenotransplantation

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“…Studies on consumer behaviour have indicated that perceived benefit and risk strongly influenced individual responses regarding acceptance of technology [36][37][38][39][40][41]. Perceived benefit is a positive predictor of attitude, while perceived risk is a negative predictor of attitude.…”

Section: Perceived Benefit and Riskmentioning

confidence: 99%

Stakeholders’ attitudes to outdoor residual spraying technique for dengue control in Malaysia: A PLS-SEM approach

et al. 2021

Self Cite

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Outdoor Residual Spraying (ORS) technique is a complementary preventive measure for dengue. The alarming number of dengue cases in Malaysia requires an alternative method to control dengue besides the traditional method such as fogging. However, the introduction of new technologies depends on social acceptance. Therefore, this study was important to determine the factors that influence stakeholders’ attitudes towards the ORS and the moderating factor. A validated instrument was used to randomly interview 399 respondents representing two stakeholder groups which consist of scientists, and the public in Klang Valley, Malaysia. The findings revealed that the stakeholders claimed to have a high degree of religiosity, a high level of trust in the key players, perceived ORS as having high benefits, and displayed highly positive attitudes towards the ORS. The attitudes model towards the ORS model was developed using the SmartPLS software version. The perceived benefit was endorsed as the most important direct predictor of attitudes towards the ORS (ß = 0.618, P<0.001), followed by trust in the key players (ß = 0.151, P<0.001). It is also interesting to note that religiosity served as a moderator for the association between perceived benefit (ß = 0.075, P = 0.024) and perceived risk (ß = 0.114, P = 0.006) with attitudes towards the ORS. The identified predictor factors of stakeholders’ attitudes toward the ORS and the moderating factor can serve as indicators for social acceptance of ORS in developing countries. These indicators can help the policymakers in decision making to implement this technique.

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“…The uptake of xenotransplantation depends on both research advancements and public approval. In Malaysia, 469 people were surveyed to predict perspectives on religion, perceived benefits, and risks, among others . Their results describe the attitudes of stakeholders involved in xenotransplantation, exemplifying the need for a multidimensional outlook …”

Section: Viewpointsmentioning

confidence: 99%