Determinants of serum IgG responses to periodontal bacteria in a nationally representative sample of US adults

Vlachojannis, Christian; Dye, Bruce A.; Herrera‐Abreu, Miriam; Pikdöken, Levent; Lerche-Sehm, Julia; Pretzl, Bernadette; Celenti, Romanita; Papapanou, Panos N.

doi:10.1111/j.1600-051x.2010.01592.x

Cited by 49 publications

(75 citation statements)

References 44 publications

(54 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, these two strains also have different fimbrial and outer membrane serotypes,21 31 and a set of common antigens shared among species based on genomic data. The association between 19 bacterial antibodies and measured clinical indices of oral health was examined in a large US population study (the third National Health and Nutrition Examination Survey) 32. Of the 19 antibodies tested, only antibody titres to P gingivalis (mixed suspension of ATCC strains 53978 and 33277) were significantly higher in individuals with periodontitis (moderate or severe, and separately for extensive periodontitis) compared with healthy individuals (p<0.05),32 as was previously observed in smaller studies 33–36.…”

Section: Discussionmentioning

confidence: 99%

“…The association between 19 bacterial antibodies and measured clinical indices of oral health was examined in a large US population study (the third National Health and Nutrition Examination Survey) 32. Of the 19 antibodies tested, only antibody titres to P gingivalis (mixed suspension of ATCC strains 53978 and 33277) were significantly higher in individuals with periodontitis (moderate or severe, and separately for extensive periodontitis) compared with healthy individuals (p<0.05),32 as was previously observed in smaller studies 33–36. High levels of antibodies to P gingivalis ATCC 53978 may be the best antibody marker for high bacterial load and aggressive periodontal disease, which is in agreement with the third National Health and Nutrition Examination Survey data,32 and thus may explain why it was the only suspected periodontal pathogen associated with an elevated risk of pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study

Michaud

Izard

Wilhelm-Benartzi

et al. 2012

Gut

321

286

View full text Add to dashboard Cite

Objective Examine the relationship between antibodies to 25 oral bacteria and pancreatic cancer risk in a prospective cohort study. Design We measured antibodies to oral bacteria in prediagnosis blood samples from 405 pancreatic cancer cases and 416 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition study (EPIC). Analyses were conducted using conditional logistic regression and additionally adjusted for smoking status and body mass index. Results Individuals with high levels of antibodies against Porphyromonas gingivalis ATTC 53978, a pathogenic periodontal bacteria, had a 2-fold higher risk of pancreatic cancer than individuals lower levels of these antibodies (odds ratio [OR], 2.14; 95% confidence interval [CI], 1.05–4.36; >200 ng/ml vs ≤200 ng/ml). To explore the association with commensal (non-pathogenic) oral bacteria, we performed a cluster analysis and identified 2 groups of individuals, based on their antibody profiles. A cluster with overall higher levels of antibodies had a 45% lower risk of pancreatic cancer than a cluster with overall lower levels of antibodies (OR, 0.55; 95% CI, 0.36–0.83). Conclusion Periodontal disease might increase the risk for pancreatic cancer. Moreover, increased levels of antibodies against specific commensal oral bacteria, which can inhibit growth of pathogenic bacteria, might reduce the risk of pancreatic cancer. Studies are needed to determine whether oral bacteria have direct effects on pancreatic cancer pathogenesis or serve as markers of the immune response.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study

Michaud

Izard

Wilhelm-Benartzi

et al. 2012

Gut

321

286

View full text Add to dashboard Cite

show abstract

“…Data from the third National Health and Nutrition Examination Survey (NHANES III) indicate that numerous variables, including demographic, behavioural, oral and general health-related characteristics, are determinants of systemic antibody responses to periodontal pathogens 30. In addition, even if periodontitis is accompanied by a strong immune response to periodontal pathogens, seropositivity does not indicate disease activity but exposure to pathogens.…”

Section: Discussionmentioning

confidence: 99%

Periodontopathogens antibodies and major adverse events following an acute myocardial infarction: results from the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI)

Boillot

Rangé

Danchin

et al. 2016

J Epidemiol Community Health

View full text Add to dashboard Cite

show abstract

“…To this extent, a national US survey has shown that demographic, behavioural, oral and general health-related characteristics were strong determinants of systemic antibody responses to periodontal bacteria [20], [44]. In this regard, it is reasonable to consider that PCOS may well be a modifier of periodontal health status and systemic antibody responses in the female population.…”

Section: Discussionmentioning

confidence: 99%

Association between Polycystic Ovary Syndrome, Oral Microbiota and Systemic Antibody Responses

et al. 2014

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is a hormonal disorder of women that not only is the leading cause of infertility but also shows a reciprocal link with oral health. This study aimed to investigate the hypothesis that the levels of putative periodontal pathogens in saliva and their antibody response in serum are elevated in PCOS, compared to systemic health. A total of 125 women were included in four groups; 45 women with PCOS and healthy periodontium, 35 women with PCOS and gingivitis, 25 systemically and periodontally healthy women, 20 systemically healthy women with gingivitis. Salivary levels of seven putative periodontal pathogens were analyzed by quantitative real-time polymerase chain reaction and serum antibody levels were analyzed by ELISA. In women with PCOS, salivary Porphyromonas gingivalis, Fusobacterium nucleatum, Streptococcus oralis and Tannerella forsythia levels were higher than matched systemically healthy women, particularly in the case of gingivitis. Aggregatibacter actinomycetemcomitans and Treponema denticola levels were similar among study groups. The presence of PCOS also enhanced P. gingivalis, Prevotella intermedia and S. oralis serum antibody levels, when gingivitis was also present. Gingival inflammation correlated positively with levels of the studied taxa in saliva, particularly in PCOS. The presence of P. gingivalis and F. nucleatum in saliva also exhibited a strong positive correlation with the corresponding serum antibody levels. In conclusion, as an underlying systemic endocrine condition, PCOS may quantitatively affect the composition of oral microbiota and the raised systemic response to selective members of this microbial community, exerting a confounding role in resultant gingival inflammation and periodontal health. The most consistent effect appeared to be exerted on P. gingivalis.

show abstract

Determinants of serum IgG responses to periodontal bacteria in a nationally representative sample of US adults

Abstract: Demographic, behavioural, and oral- and general health-related characteristics were strong determinants of systemic antibody responses to periodontal bacteria in a nationally representative sample of US adults.

Cited by 49 publications

References 44 publications

Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study

Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study

Periodontopathogens antibodies and major adverse events following an acute myocardial infarction: results from the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI)

Association between Polycystic Ovary Syndrome, Oral Microbiota and Systemic Antibody Responses

Contact Info

Product

Resources

About