Periodontopathogens antibodies and major adverse events following an acute myocardial infarction: results from the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI)

Abstract

The present data indicate that circulating levels of periodontopathogens antibodies are not associated with an increased risk of major adverse events in patients with a prior AMI. Studies dealing with bacterial and clinical data are needed to assess the role of oral health in comprehensive cardiac rehabilitation programmes.

Periodontitis and cardiovascular diseases: Consensus report

“…The ATHEROREMO‐IVUS study failed to demonstrate an association between serum levels of IgG and IgA against P. gingivalis , A. actinomycetemcomitans , T. forsythia and P. intermedia and major adverse cardiac events (MACE) (de Boer et al, ). This is consistent with data from Boillot et al ().…”

Periodontitis and Cardiovascular Diseases. Consensus Report

“…The ATHEROREMO-IVUS study failed to demonstrate an association between serum levels of IgG and IgA against P. gingivalis, A. actinomycetemcomitans, T. forsythia and P. intermedia and major adverse cardiac events (MACE) [24]. This is consistent with data from Boillot et al [11].…”

Immunologic burden links periodontitis to acute coronary syndrome

“…We have previously reported that A. actinomycetemcomitans-and P. gingivalis -specific serum IgA associates with myocardial infarction [41,43]. In a recent study by Boillot et al, systemic IgA levels to four periodontal pathogens showed no association with major cardiac events in a 1 year follow up of patients with prior myocardial infarction [47]. An inconclusive association has been reported for plasma IgG/IgA levels against four major periodontal pathogens and the extent of coronary atherosclerosis, coronary plaque vulnerability and coronary remodeling, although the sum of IgA levels had an inverse association with positive lesion remodeling [48].…”