Determinants of quality of life in patients with drug-resistant focal epilepsy

Silva, Bruno; Canas-Simião, Hugo; Cordeiro, Susana Arruda; Velosa, Ana; Oliveira‐Maia, Albino J.; Barahona-Corrêa, Bernardo

doi:10.1016/j.yebeh.2019.106525

Cited by 21 publications

(16 citation statements)

References 27 publications

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“…Population-based investigations have demonstrated the increased prevalence of somatic, 1 cognitive, 2 and psychiatric 3,4 comorbidities of the epilepsies which are costly, 5 increase healthcare utilization, 6 and decrease quality of life. 7,8 Neurobehavioral complications may be even more prevalent in patients presenting for care at specialized medical centers, but considerable heterogeneity in their presence and severity has been demonstrated. By way of example, cognitive abnormalities are an especially problematic complication of temporal lobe epilepsy (TLE) and its neuropsychological profile is now known to be heterogeneous and reflected in reproducible cognitive phenotypes.…”

Section: Introductionmentioning

confidence: 99%

Behavioral phenotypes of temporal lobe epilepsy

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Behavioral phenotypes of temporal lobe epilepsy

et al. 2021

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“…A recent study from Portugal has stated that being female is the second significant determinant for the lower QoL. 21 The three pillars of quality of health care, such as availability, accessibility, and affordability are different in urban and rural communities. 8 More over when it comes to the rural areas, apart from the above mentioned three factors patients from rural areas come across additional adversities, which impact their QoL.…”

Section: Discussionmentioning

confidence: 99%

Quality of Life and Stigma among Women with Epilepsy during Their Reproductive Years

Srikanth¹,

Vranda²,

Thomas³

et al. 2021

J Epilepsy Res

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Background and Purpose: The purpose of this study was to understand the relationship between quality of life and stigma among reproductive age group women with epilepsy.Methods: A cross-sectional descriptive study was conducted to assess the data from the 49 women with epilepsy from a tertiary care hospital in India. Quality of life was evaluated with the quality of life in epilepsy-31 questionnaire and stigma was evaluated with the stigma scale of epilepsy. Data also included socio-demographic and clinical characteristics.Results: The mean age of the participants was 24.67±3.72 years. Quality of life total score (r=-0.485**) and seizure worry domain (r=-0.427**) were significantly negatively correlated with stigma total score at p<0.01 level. Being uneducated, married, unemployed, having children, having generalized tonic-clonic seizures, duration of illness (˃10 years), and consuming levetiracetam, anti-epileptic drug (AED), were the significant contributing factors for low quality of life among women with epilepsy during the reproductive age group. Belonging to lower socio-economic status and taking more than two AEDs were also associated with lower quality of life among women with epilepsy, which are trending towards significance.Conclusions: The study assessed the relationship between the quality of life and the Stigma scale of epilepsy and demonstrated the impact of stigma and quality of life on socio-demographic and clinical variables of women with epilepsy under the reproductive age group. To enhance the quality of life and reduce the stigma levels among women with epilepsy, some of the modifiable parameters can be considered by the multidisciplinary health care professionals from the findings of the current research.

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“…Since that review, several single‐center studies have assessed the relationship of QoL with DRE; however, these studies were conducted outside of the United States and did not take a comprehensive multivariate approach including HCRU 6,8,19,20 . In addition, one of the studies focused only on patients with focal epilepsy.…”

Section: Significancementioning

confidence: 99%

“…Advancements in antiepileptic drug (AED) treatments have resulted in the potential for the complete remission of seizures in patients with epilepsy 1 . However, approximately 30%–40% of adult patients have drug‐resistant epilepsy (DRE; defined as failure to achieve sustained seizure remission despite adequate trials of two appropriately chosen and used AEDs), and continue to experience seizures despite multiple treatment attempts, 2–5 resulting in a significant economic burden and decrease in quality of life (QoL) for patients and their caregivers 5–8 …”

Section: Introductionmentioning

confidence: 99%

Quantifying the burden of generalized tonic‐clonic seizures in patients with drug‐resistant epilepsy

et al. 2020

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Objective: Compared to other seizure types, generalized tonic-clonic (GTC) seizures may be disproportionately related to increased morbidity, and reducing seizure frequency could translate into improvements across measures of morbidity in medically treated patients with drug-resistant epilepsy (DRE). The primary objective of this analysis was to quantify the burden of patients with DRE who experience GTC seizures (GTC+) compared to patients with DRE who do not experience GTC seizures (GTC−). Methods: Adult patients from the Cleveland Clinic Epilepsy Center-Neurological Institute from 2012-2016 with DRE with epilepsy for at least 1 year were eligible for inclusion and were divided into GTC ± groups based on whether the patient had experienced a GTC seizure in the year preceding the first visit. Epilepsy duration, comorbidities, antiepileptic drug use, patient-reported outcomes (PROs) and seizure type, frequency, and etiology were captured. Generalized linear models, negative binomial regression, logistic regression, and linear regression were used as appropriate for multivariate analyses. Results: A total of 379 patients met inclusion criteria and had data at 1-year followup after their baseline visit (192 GTC+ and 187 GTC−). Although DRE patients experiencing GTC seizures had fewer seizures per day over the preceding 6 months than those not experiencing GTC seizures, seizure severity and levels of depression and anxiety were greater. GTC+ patients who reported five or more seizures in the preceding 4 weeks had 82% lower odds (1−0.18 = 0.82) of working than patients with no seizures. Significance: Patients with DRE experience a significant burden and decreased quality of life. Multivariate analysis is necessary to understand the complex relationship between seizure type, frequency, and impact on health-related quality of life (HRQoL) and changes over time. Effective treatments to reduce the burden for DRE patients who experience GTC seizures continue to be needed.

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Determinants of quality of life in patients with drug-resistant focal epilepsy

Cited by 21 publications

References 27 publications

Behavioral phenotypes of temporal lobe epilepsy

Behavioral phenotypes of temporal lobe epilepsy

Quality of Life and Stigma among Women with Epilepsy during Their Reproductive Years

Quantifying the burden of generalized tonic‐clonic seizures in patients with drug‐resistant epilepsy

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