Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort

Jacques, Paul F.; Bostom, Andrew G.; Wilson, Peter W.F.; Rich, Sharron; Rosenberg, Irwin H.; Selhub, Jacob

doi:10.1093/ajcn/73.3.613

Cited by 574 publications

(463 citation statements)

References 42 publications

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“…Our results do not support an effect of increased adipose mass on plasma homocysteine concentrations. These results are in agreement with other published work [45,46], although some authors have found a weak correlation between plasma homocysteine and BMI [47]. Fibrinogen, CRP and vWF were negatively correlated with the QUICKI index.…”

Section: Discussionsupporting

confidence: 93%

Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors

Gómez-Ambrosi

Salvador

Páramo

et al. 2002

Clinical Biochemistry

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Objectives: Recent epidemiologic studies have shown that obesity is associated with elevated blood concentrations of prothromboticproinflammatory factors and markers of endothelial dysfunction such as fibrinogen, C-reactive protein (CRP), von Willebrand factor (vWF), and homocysteine. We have assessed whether these markers are associated with percentage of body fat (BF), insulin sensitivity as well as with leptin concentrations. Design and methods: Twenty-five men aged 49.6 Ϯ 12.7 yr (mean Ϯ SD) underwent whole-body air displacement plethysmography (Bod-Pod ® ) for estimating BF. Blood analyses for leptin and several other metabolic and cardiovascular markers were carried out. Results: Obese subjects had higher levels as compared to controls of BF (37.5 Ϯ 5.1 vs. 26.0 Ϯ 6.6, p Ͻ 0. Conclusions: Increased BF and impaired insulin sensitivity are associated with increased concentrations of cardiovascular risk factors. Leptin seems to be involved in this elevation and emerges as a predictor of circulating fibrinogen concentrations.

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Section: Discussionsupporting

confidence: 93%

Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors

Gómez-Ambrosi

Salvador

Páramo

et al. 2002

Clinical Biochemistry

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“…Vitamin deficiency is among the principal causes of elevated tHcy in the general population (Selhub et al, 1993;Clarke & Armitage, 2000). In addition to diet, other lifestyle factors such as smoking, physical activity, and consumption of alcohol, coffee and tea may have an effect on tHcy concentrations in the general population (Nygard et al, 1995(Nygard et al, , 1997(Nygard et al, , 1998Ubbink et al, 1998;Rasmussen et al, 2000;De Bree et al, 2001a;Jacques et al, 2001;Koehler et al, 2001;Mayer et al, 2001;Saw et al, 2001). The thermolabile variant of the methylenetetrahydrofolate reductase (MTHFR(C677T)), a regulating enzyme in tHcy metabolism, is an important genetic determinant of tHcy (Frosst et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

“…A few studies have explored the associations between tHcy and multiple lifestyle factors in large representative samples of the general population (Nygard et al, 1995(Nygard et al, , 1998De Bree et al, 2001a;Jacques et al, 2001). However, these studies have not adjusted for the confounding effects of the MTHFR(C677T) polymorphism nor considered the potential gene-lifestyle interactions.…”

Section: Introductionmentioning

confidence: 99%

Effect of lifestyle factors on plasma total homocysteine concentrations in relation to MTHFR(C677T) genotype. Inter99 (7)

et al. 2004

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Objective: To examine the associations between various lifestyle factors-smoking habits, physical activity, dietary habits, coffee, tea, and alcohol consumption-and homocysteine (tHcy) in relation to MTHFR(C677T) genotype. Design: Cross-sectional population-based study. Setting: Residents of Copenhagen County, Denmark. Subjects: A random sample of 6457 men and women aged 30-60 years drawn from the Civil Registration System and invited to a health examination in 1999-2001. A total of 2788 participants were included in the statistical analysis. Main outcome measures: tHcy was measured using a Fluorescent Polarization Immuno Assay. MTHFR-genotype was determined by PCR and RFLP analysis. Information about lifestyle factors was obtained from a self-administered questionnaire. Results: Daily smoking, less healthy dietary habits, and coffee drinking were associated with elevated tHcy concentrations independent of other determinants. Wine consumption was related to tHcy in a J-shaped manner, whereas beer consumption was negatively associated with tHcy after multiple adjustments. Interaction was observed between smoking status and MTHFRgenotype, smoking status and sex, and beer consumption and age. The effect of smoking was more pronounced in persons with the TT genotype and in women. The effect of beer consumption was more pronounced at younger than at older ages. Conclusions: Smoking status, dietary habits, coffee intake, wine, and beer consumption were major lifestyle determinants of tHcy. Changes in these lifestyle factors may reduce tHcy concentrations, thereby lowering cardiovascular risk in the general population.

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“…It has been suggested that unfiltered coffee increases plasma homocysteine concentrations in people with normal baseline concentrations. 2,4,5,11,12 Randomized clinical trials suggest that there is a homocysteine-raising effect of both filtered 13 and unfiltered coffee. 2 However, coffee intake in these studies was high (1 l per day) and at these levels of consumption, our results agree with the results of the above studies.…”

Section: Discussionmentioning

confidence: 99%

“…1 A randomized clinical trial 3 and some population studies have suggested that a high intake of coffee is associated with raised concentrations of plasma homocysteine. 4,5 On the other hand, no association between coffee consumption and plasma homocysteine levels was observed in participants of the Atherosclerosis Risk in Communities (ARIC) study. 6 These discrepant findings may be attributed to the quantity and type of coffee consumed.…”

Section: Introductionmentioning

confidence: 99%

Erratum to: Patients with mild hypertensive heart disease and left ventricular outflow tract obstruction: treatment with angiotensin II antagonists

Panagiotakos

Pitsavos²,

Zampelas³

et al. 2004

Heart Vessels

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The aim of this work was to investigate the association between homocysteine levels and coffee consumption in a sample of cardiovascular disease-free men and women. From May 2001 to December 2002, we randomly enrolled 1514 men and 1528 women, stratified by age and gender, from the greater area of Athens. Blood samples were collected in the fasting state. Among other investigated factors, dietary habits (including coffee consumption in ml per day, adjusted for 28% caffeine containment) were evaluated using a validated food frequency questionnaire. Men consumed higher quantities of coffee compared with women (250 Ϯ 55 vs 150 Ϯ 60 ml/day, P ϭ 0.001), while homocysteine values were also higher in men than in women (14.5 Ϯ 6 vs 10.8 Ϯ 3.5 µmol/l, P ϭ 0.001). A doseresponse relationship of homocysteine levels with coffee consumption was observed (r ϭ 0.10, P ϭ 0.034). In particular, we found that homocysteine levels were 11.2 Ϯ 5 µmol/ l for no consumption, 11.7 Ϯ 7 µmol/l for Ͻ100 ml/day, 12.5 Ϯ 7µmol/l for 200-400 ml/day, and 12.7 Ϯ 4µmol/l for Ͼ500 ml/day consumption (P ϭ 0.018). The observed trend remained significant even after controlling for the interactions between coffee consumption with gender, smoking habits, physical activity status, and eating habits. However, the sole effect of the consumption of filtered coffee on homocysteine levels was significant only in those who consumed more than 500 ml/day (P ϭ 0.043). Although our findings cannot be evidence for causality, they can be the basis for hypotheses about the relation between homocysteine and coffee that can partially explain the mechanisms by which elevated homocysteine levels may influence coronary risk.

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Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort

Cited by 574 publications

References 42 publications

Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors

Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors

Effect of lifestyle factors on plasma total homocysteine concentrations in relation to MTHFR(C677T) genotype. Inter99 (7)

Erratum to: Patients with mild hypertensive heart disease and left ventricular outflow tract obstruction: treatment with angiotensin II antagonists

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