Effect of lifestyle factors on plasma total homocysteine concentrations in relation to MTHFR(C677T) genotype. Inter99 (7)

Husemoen, L L N; Thomsen, Troels; Fenger, Mogens; Jørgensen, Torben

doi:10.1038/sj.ejcn.1601942

Cited by 42 publications

(49 citation statements)

References 54 publications

(86 reference statements)

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“…Essentially the same questions were asked at the baseline and the follow-up examinations. The recording of smoking status, physical activity and the consumption of alcoholic beverages, coffee and tea has been described previously (Husemoen et al, 2004).…”

Section: Self-administered Questionnairementioning

confidence: 99%

“…Based on responses to qualitative questions about intake of fruit, vegetables, fish, and saturated fat, a crude dietary score was calculated as described previously (Husemoen et al, 2004). Changes in dietary habits between baseline and follow-up were categorized into three categories: healthier dietary habits, unchanged dietary habits and unhealthier dietary habits.…”

Section: Self-administered Questionnairementioning

confidence: 99%

“…Reduction in tHcy may thus be clinically relevant in the prevention of CVD, and it is therefore important to identify modifiable factors that influence tHcy. Lifestyle factors such as vitamin intake, smoking, physical activity and consumption of alcohol, coffee and tea have been related to tHcy in several cross-sectional populationbased studies (Nygard et al, 1998;El Khairy et al, 1999;Rasmussen et al, 2000;De Bree et al, 2001a, b;Saw et al, 2001;Husemoen et al, 2004). Moreover, tHcy has also been associated with various lifestyle-related biological CVD risk markers such as blood pressure, cholesterol and different measures of body weight (Nygard et al, 1995;Jacques et al, 2001;Panagiotakos et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…Whether an altered lifestyle and changes in lifestyle-related factors are associated with changes in tHcy have not been thoroughly investigated. The thermolabile variant of the methylenetetrahydrofolate reductase (MTHFR(C677T)) (Frosst et al, 1995), a regulating enzyme in tHcy metabolism, has been shown to modify the relation between several lifestyle factors and tHcy (Jacques et al, 1996;Hustad et al, 2000;Jacques et al, 2002;Husemoen et al, 2004). Thus the effect on tHcy of changes in lifestyle related factors may depend on MTHFR(C677T) genotype.…”

Section: Introductionmentioning

confidence: 99%

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Changes in lifestyle and total homocysteine in relation to MTHFR(C677T) genotype: the Inter99 study

et al. 2005

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Background: Reduction in total homocysteine (tHcy) may be clinically relevant in the prevention of cardiovascular disease (CVD) in the general population. Objective: To examine the effects of changes in various lifestyle habits and lifestyle related biological CVD risk markers on changes in tHcy in relation to MTHFR(C677T) genotype. Design: A 1 year follow-up study. Setting: Copenhagen County, Denmark. Subjects: Statistical analyses were based on a population-based sample of 915 men and women aged 30-60 years assessed to be at increased CVD risk at baseline and therefore offered lifestyle intervention and re-examination after one year. Results: None of the studied lifestyle changes -smoking, physical activity, dietary habits, and coffee, tea, and alcohol consumption -was significantly associated with changes in tHcy, either overall, or in any of the MTHFR genotype subgroups. In addition, changes in tHcy did not differ between participants randomized to low-and high-intensity lifestyle intervention. However, the MTHFR TT genotype was associated with a significant decrease in tHcy compared with the CC/CT genotype in which an increase was observed. In addition, changes in tHcy were associated with changes in several of the biological CVD risk markers: weight, total cholesterol, HDL cholesterol, LDL cholesterol and systolic blood pressure. Conclusions: Our results indicate that tHcy may not be reduced by lifestyle changes; additionally, they suggest that tHcy may be related to biological CVD risk markers through a lifestyle independent pathway.

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Section: Self-administered Questionnairementioning

confidence: 99%

Section: Self-administered Questionnairementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Changes in lifestyle and total homocysteine in relation to MTHFR(C677T) genotype: the Inter99 study

et al. 2005

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“…Moreover, 82 discrepancies within these human studies, including B-vitamin and subject training status, as 83 well as variations in mode, intensity, and duration of test exercises, limit the strength of their 84 conclusions [16,17]. Mechanistically, reductions in homocysteine concentrations by exercise 85 may be related to increased protein turnover owing to increased plasma methionine 86 concentrations during exercise, followed by reduced concentrations below basal levels after 87 exercise [18][19][20][21].…”

mentioning

confidence: 99%

Exercise prevents hyperhomocysteinemia in a dietary folate-restricted mouse model

Neuman¹,

Albright²,

Schalinske³

2013

Nutrition Research

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Hyperhomocysteinemia is a condition that results from altered methyl group metabolism and is associated with numerous pathological conditions. A number of nutritional and hormonal factors have been shown to influence circulating homocysteine concentrations; however, the impact of exercise on homocysteine and methyl group balance is not well understood. Our hypothesis was that exercise represents an effective means to prevent hyperhomocysteinemia in a folate-independent manner. The purpose of this study was to determine the influence of exercise on homocysteine metabolism in a dietary folate-restricted mouse model characterized by moderate hyperhomocysteinemia. Female outbred mice (12 weeks old) were assigned to either a sedentary or free-access wheel exercise group. Following a 4-week acclimation period, half of the mice in each group were provided a folate-restricted diet for 7-weeks prior to euthanasia and tissue collection. As expected, folate-restricted sedentary mice exhibited a 2-fold increase in plasma total homocysteine concentrations; however, exercise completely prevented the increase in circulating homocysteine concentrations. Moreover, exercise reduced plasma homocysteine concentrations 36% within the group fed only the control diet. The prevention of hyperhomocysteinemia by exercise appears, at least in part, to be the result of increased folate-independent homocysteine remethylation owing to a 2-fold increase in renal betaine homocysteine S-methyltransferase. To our knowledge, this is the first report demonstrating the prevention of hyperhomocysteinemia by exercise in a dietary folate-restriction model. Future research will be directed at determining if exercise can have a positive impact on other nutritional, hormonal, and genetic models of hyperhomocysteinemia relevant to humans. Hyperhomocysteinemia is a condition that results from altered methyl group metabolism and is 30 associated with numerous pathological conditions. A number of nutritional and hormonal factors 31 have been shown to influence circulating homocysteine concentrations; however, the impact of 32 exercise on homocysteine and methyl group balance is not well understood. Our hypothesis was 33 that exercise represents an effective means to prevent hyperhomocysteinemia in a folate-34 independent manner. The purpose of this study was to determine the influence of exercise on 35 homocysteine metabolism in a dietary folate-restricted mouse model characterized by moderate 36 hyperhomocysteinemia. Female outbred mice (12 wk old) were assigned to either a sedentary or 37 free-access wheel exercise group. Following a 4-wk acclimation period, half of the mice in each 38 group were provided a folate-restricted diet for 7-wk prior to euthanasia and tissue collection. As 39 expected, folate-restricted sedentary mice exhibited a 2-fold increase in plasma total 40 homocysteine concentrations; however, exercise completely prevented the increase in circulating 41 homocysteine concentrations. Moreover, exercise reduced plasma homocysteine c...

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Methylenetetrahydrofolate reductase C677T genotype and PD

Lau

Koudstaal

Meurs

et al. 2005

Annals of Neurology

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In a prospective, population-based cohort study among 5,920 participants aged 55 years or older, we observed that the TT variant of the methylenetetrahydrofolate reductase C677T polymorphism is associated with an increased risk for Parkinson's disease in smokers. Both smoking and the TT genotype are known to induce hyperhomocystinemia, and synergistic effects on homocysteine levels have been reported. Increased plasma levels of homocysteine through direct neurotoxic effects might accelerate the selective dopaminergic cell death underlying Parkinson's disease. Our findings support the hypothesis that homocysteine plays a role in the pathogenesis of Parkinson's disease.

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Effect of lifestyle factors on plasma total homocysteine concentrations in relation to MTHFR(C677T) genotype. Inter99 (7)

Cited by 42 publications

References 54 publications

Changes in lifestyle and total homocysteine in relation to MTHFR(C677T) genotype: the Inter99 study

Changes in lifestyle and total homocysteine in relation to MTHFR(C677T) genotype: the Inter99 study

Exercise prevents hyperhomocysteinemia in a dietary folate-restricted mouse model

Methylenetetrahydrofolate reductase C677T genotype and PD

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