Determinants of Health-Related Quality of Life in Psoriasis Patients in Malaysia

Nyunt, Wint Wint; Low, Wah Yun; Ismail, Razidah; Sockalingam, Sargunan; Min, Aung Ko Ko

doi:10.1177/1010539513492561

Cited by 24 publications

(25 citation statements)

References 15 publications

(30 reference statements)

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“…One-third (33.1%) of our patients had a DLQI score of more than 10, which indicates severe impairment. This was similar to a local study on 223 patients, evaluating the HRQoL using DLQI [ 34 ]. The study reported 67 patients (30%) with severe impairment (DLQI score = 11–30) and a median DLQI score of 7.…”

Section: Discussionsupporting

confidence: 86%

Epidemiology and Clinical Features of Adult Patients with Psoriasis in Malaysia: 10-Year Review from the Malaysian Psoriasis Registry (2007–2016)

Affandi

Khan

Saaya

2018

Dermatology Research and Practice

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Background Psoriasis is a chronic inflammatory skin disease affecting 2-3% of the general population. Aim To evaluate the epidemiology and clinical characteristics of patients with psoriasis who seek treatment in outpatient dermatology clinics throughout hospitals in Malaysia. Materials and Methods Data were obtained from the Malaysian Psoriasis Registry (MPR). All patients (aged 18 and above) who were notified to the registry from July 2017 to December 2017 were included in this study. Results Among 15,794 patients, Malays were the most common (50.4%), followed by Chinese (21.4%), Indian (17.6%), and others (10.6%). The mean age onset of psoriasis for our study population was 35.14 ± 16.16 years. Male to female ratio was 1.3 : 1. 23.1% of patients had positive family history of psoriasis. The most common clinical presentation was chronic plaque psoriasis (85.1%), followed by guttate psoriasis (2.9%), erythrodermic psoriasis (1.7%), and pustular psoriasis (1.0%). Majority of our patients (76.6%) had a mild disease with BSA < 10%. 57.1% of patients had nail involvement, while arthropathy was seen in 13.7% of patients. Common triggers of the disease include stress (48.3%), sunlight (24.9%), and infection (9.1%). Comorbidities observed include obesity (24.3%), hypertension (25.6%), hyperlipidemia (18%), diabetes mellitus (17.2%), ischaemic heart disease (5.4%), and cerebrovascular disease (1.6%). The mean DLQI (Dermatology Life Quality Index) was 8.5 ± 6.6. One-third (33.1%) of the patients had a DLQI score of more than 10, while 14.2% of patients reported no effect at all. Conclusion Our study on the epidemiological data of adult patients with psoriasis in Malaysia showed a similar clinical profile and outcome when compared to international published studies on the epidemiology of psoriasis.

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Section: Discussionsupporting

confidence: 86%

Epidemiology and Clinical Features of Adult Patients with Psoriasis in Malaysia: 10-Year Review from the Malaysian Psoriasis Registry (2007–2016)

Affandi

Khan

Saaya

2018

Dermatology Research and Practice

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“…Similar results were shown in patient populations affected by other skin diseases accompanied by itch, such as urticaria [25] and psoriasis [21,26,27]. One study investigating psychological factors associated with hand dermatoses showed that high stress responders stated significantly higher values for itch [28].…”

Section: Discussionsupporting

confidence: 64%

Itching in Patients with Chronic Hand Eczema: Data from the CARPE Registry

et al. 2014

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Background: Itching is a leading symptom of chronic hand eczema (CHE) having a great impact on patients. The determinants of itching in CHE are unclear. Objective: We performed a cross-sectional analysis investigating factors associated with the presence and severity of itch in CHE patients from the CARPE registry. Methods: We present baseline data on itch in relationship with sociodemographic factors, severity of CHE, atopy, contact allergy, treatment and patient- reported outcomes including health-related quality of life (HRQoL). Results: Of 1,051 patients with CHE, 78.1% reported itching. Significant positive associations with itching were observed for younger age groups (17-25 and 26-45 years), for moderate, severe and very severe CHE and for small/moderate impairment in HRQoL. Atopic skin diathesis, hardly being able to realize treatment recommendations and very or extremely large impairments in HRQoL were associated with itch severity. Conclusion: Taking the identified variables into account may help identify vulnerable groups most affected by (severe) itch.

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“…Four studies used non-validated questionnaires [ 25 , 51 – 53 ] three of which contained a single item pertaining to sleep disturbance [ 25 , 52 , 53 ] (e.g "in a typical month, how many days did your disease interfere with sleeping?”) [ 25 ]. Four studies solely used medical records [ 54 , 55 , 56 , 57 ], and another used a clinical diagnostic interview with a sleep disorder diagnosis [ 58 ]. In two validation studies HRQoL was assessed using a willingness-to-pay paradigm, where participants were asked to indicate how much money they would allocate to relieve themselves of a particular symptom [ 59 , 60 ].…”

Section: Resultsmentioning

confidence: 99%

“…Sleep disturbance was consistently associated with reduced QOL [ 28 , 47 , 54 , 58 ]. Moreover, in four treatment studies using biologics, improvements were observed in sleep quality, disturbance, daytime sleepiness and adequacy [ 26 , 41 , 43 , 46 ] suggesting that improvements in psoriasis disease processes may lead to concomitant improvements in sleep.…”

Section: Resultsmentioning

confidence: 99%

Measurement, Classification and Evaluation of Sleep Disturbance in Psoriasis: A Systematic Review

et al. 2016

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BackgroundPsoriasis is a long-term immune-mediated inflammatory disorder mainly, but not only, affecting skin, and is associated with significant medical and psychological morbidity. Evidence suggests that sleep is disrupted in psoriasis, however high quality empirical evidence is lacking. Given the importance of sleep for health, characterisation of sleep disruption in psoriasis is an important goal. We therefore conducted a systematic review of the sleep-psoriasis literature.MethodsSearches were conducted in Pubmed, SCOPUS and Web of Science from inception to May 2016. Studies were compared against inclusion/exclusion criteria and underwent a quality evaluation. Given the heterogeneity of studies, we conducted a narrative synthesis of the findings.ResultsSearches revealed 32 studies which met our predetermined inclusion/exclusion criteria. Whilst 93.7% of studies reported sleep disruption in this population, ranging from 0.05% to 85.4%, many had important methodological shortcomings. Over half of all quantitative studies (54.8%; 17/31) relied on non-validated measures, contributing to heterogeneity in study findings. In those that employed valid measures, assessing sleep was often not the primary objective. We frequently found the absence of adequate sample size calculations and poor statistical reporting.ConclusionThis review showed that in psoriasis, reported sleep rates of sleep disturbance varied substantially. Most studies lacked a hypothesis driven research question and/or failed to use validated measures of sleep. We were unable to draw firm conclusions about the precise prevalence and nature of sleep disturbance within the psoriasis population. We offer suggestions to help advance understanding of sleep disturbance in psoriasis.

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Determinants of Health-Related Quality of Life in Psoriasis Patients in Malaysia

Cited by 24 publications

References 15 publications

Epidemiology and Clinical Features of Adult Patients with Psoriasis in Malaysia: 10-Year Review from the Malaysian Psoriasis Registry (2007–2016)

Epidemiology and Clinical Features of Adult Patients with Psoriasis in Malaysia: 10-Year Review from the Malaysian Psoriasis Registry (2007–2016)

Itching in Patients with Chronic Hand Eczema: Data from the CARPE Registry

Measurement, Classification and Evaluation of Sleep Disturbance in Psoriasis: A Systematic Review

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