Determinants of health-related quality of life in Crohn's disease: A systematic review and meta-analysis

Have, Mike van der; Aalst, Karen S. van der; Kaptein, Ad A.; Leenders, Max; Siersema, Peter D.; Oldenburg, Bas; Fidder, Herma H.

doi:10.1016/j.crohns.2013.04.007

Cited by 120 publications

(95 citation statements)

References 60 publications

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“…It is known that poor HRQOL is associated with active disease [3, 5, 23, 27-29], which was also apparent in this study. HRQOL improved significantly once treatment was initiated, suggesting that improvements in HRQOL were related to reduced symptoms of active disease.…”

Section: Discussionsupporting

confidence: 75%

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Newly Diagnosed Crohn’s Disease Treated with Standard Care or Enteral Nutrition: Psychological Outcomes over 6 Months

et al. 2019

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Background and Aim: Impaired health-related quality of life and higher rates of anxiety and depression are observed in patients with Crohn’s disease. This single center study aimed to describe and compare longitudinal psychological outcomes of newly diagnosed Crohn’s disease patients treated with standard care or enteral nutrition to induce remission. Methods:Two separate cohorts of patients were recruited from one center and treated with standard care (n = 22) or enteral nutrition (n = 18) to induce disease remission. Disease activity, quality of life, anxiety, and depression were assessed at diagnosis and month 6. Results:At baseline, quality of life (n = 40) was not correlated with disease activity; symptoms of anxiety and depression were present in 15 (38%) and 5 (13%) of the 40 patients, respectively. Significant improvements in quality of life (p <0.0001) and anxiety scores (p = 0.002) were observed after 2 weeks of exclusive enteral nutrition, and at month 6 significant improvements in all psychological outcomes were observed. At month 6, patients who received standard care had a significant improvement in quality of life (p = 0.004), but not in anxiety or depression scores, and there were no differences in psychological outcomes between the treatment groups. Overall, 34/40 (85%) patients were in clinical remission at month 6, and a clinically significant quality of life score was achieved by 31/40 (78%). Conclusions:Patient health-related quality of life and symptoms of anxiety and depression improved as disease activity improved, and 6 months after diagnosis psychological outcomes were similar in patients treated with standard care or enteral nutrition to initially induce remission.

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Section: Discussionsupporting

confidence: 75%

“…The determinants of HRQOL are varied and may include disease treatments, disease activity, and hospitalization [3]. Drug treatments affect HRQOL of patients with inflammatory bowel disease (IBD) variably.…”

Section: Introductionmentioning

confidence: 99%

Newly Diagnosed Crohn’s Disease Treated with Standard Care or Enteral Nutrition: Psychological Outcomes over 6 Months

et al. 2019

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“…This accumulation is suspected to progressively impair the intestinal function and the quality of life. [8] Active chronic UC can also induce a loss of colonic function [2] and an increased risk of colonic cancer. [9] Our definition of mild CD and UC also excluded the requirement of IM or anti-TNF in the course of the disease because they are usually associated with a worsening of the disease and with an increased incidence of infectious [10][11][12] and oncologic complications.…”

Section: Discussionmentioning

confidence: 99%

Long-term evolution and predictive factors of mild inflammatory bowel disease

Reenaers

Pirard

Vankemseke

et al. 2016

Scandinavian Journal of Gastroenterology

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“…Previous studies have shown that HRQOL is significantly impaired by work disability (2,3,17,42) . The work disability rates of IBD patients range between 1.3% and 34% (45) . The frequent flares requiring hospitalization or surgical intervention often leads to sick leave and disability pensions (2,3,4,6,20,44) , which may be the main reason for the decreased career fulfillment in IBD patients.…”

Section: Discussionmentioning

confidence: 99%

QUALITY OF LIFE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: importance of clinical, demographic and psychosocial factors

Magalhães¹,

Castro²,

Carvalho³

et al. 2014

Arq. Gastroenterol.

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-Context -Inflammatory bowel disease causes physical and psychosocial consequences that can affect the health related quality of life. Objectives -To analyze the relationship between clinical and sociodemographic factors and quality of life in inflammatory bowel disease patients. Methods -Ninety two patients with Crohn's disease and 58 with ulcerative colitis, filled in the inflammatory bowel disease questionnaire (IBDQ-32) and a questionnaire to collect sociodemographic and clinical data. The association between categorical variables and IBDQ-32 scores was determined using Student t test. Factors statistically significant in the univariate analysis were included in a multivariate regression model. Results -IBDQ-32 scores were significantly lower in female patients (P<0.001), patients with an individual perception of a lower co-workers support (P<0.001) and career fulfillment (P<0.001), patients requiring psychological support (P = 0.010) and pharmacological treatment for anxiety or depression (P = 0.002). A multivariate regression analysis identified as predictors of impaired HRQOL the female gender (P<0.001) and the perception of a lower co-workers support (P = 0.025) and career fulfillment (P = 0.001). Conclusion -The decrease in HRQQL was significantly related with female gender and personal perception of disease impact in success and social relations. These factors deserve a special attention, so timely measures can be implemented to improve the quality of life of patients. HEADINGS -Inflammatory bowel diseases. Crohn disease. Ulcerative colitis. Quality of life. Questionnaires.

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Determinants of health-related quality of life in Crohn's disease: A systematic review and meta-analysis

Cited by 120 publications

References 60 publications

Newly Diagnosed Crohn’s Disease Treated with Standard Care or Enteral Nutrition: Psychological Outcomes over 6 Months

Newly Diagnosed Crohn’s Disease Treated with Standard Care or Enteral Nutrition: Psychological Outcomes over 6 Months

Long-term evolution and predictive factors of mild inflammatory bowel disease

QUALITY OF LIFE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: importance of clinical, demographic and psychosocial factors

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