Determinants of exposure levels of bisphenols in flemish adolescents

Gys, Celine; Bastiaensen, Michiel; Bruckers, Liesbeth; Colles, Ann; Govarts, Eva; Martín, Laura Rodríguez; Verheyen, Veerle J.; Koppen, Gudrun; Morrens, Bert; Hond, Elly Den; Decker, Annelies De; Schoeters, Greet

doi:10.1016/j.envres.2020.110567

Cited by 31 publications

(22 citation statements)

References 71 publications

(126 reference statements)

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“…Household educational attainment was high in this study: 59.4% of the households had a parent that achieved a tertiary educational level compared to 41% in Flanders ( 45 ). This tendency was also observed in previous FLEHS studies and is due to better response rates in highly educated households ( 46 , 47 ). The average ADI of 12% in our study population is slightly lower than the Flemish ADI of 14.5% ( 48 ).…”

Section: Resultssupporting

confidence: 84%

Determinants of Chronic Biological Stress, Measured as Hair Cortisol Concentration, in a General Population of Adolescents: From Individual and Household Characteristics to Neighborhood Urbanicity

Verheyen

Remy

Govarts

et al. 2021

Front. Public Health

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Chronic biological stress may adversely affect adolescents' physical and mental health, but insight in the personal and environmental factors that determine chronic stress is limited. We measured 3-month cumulative hair cortisol concentration (HCC) in 419 adolescents, participating in the Flemish Environment and Health Study. Adolescents' health and lifestyle characteristics, household and neighborhood socio-economic status as well as neighborhood urbanicity were assessed as potential determinants of HCC, using multiple linear regression models. We additionally explored heterogeneity of our results by sex. HCC were significantly higher in boys from densely populated neighborhoods, the association was not significant in girls. Accordingly, boys living outside cities had significantly lower HCC than boys, living in cities. HCC was significantly lower in adolescents with an optimal vitality, a measure of a positive mental health status. In adolescent girls, menarcheal status (pre-/postmenarche) was a significant determinant of HCC. Our findings are the first to suggest that residential urbanicity may have an impact on chronic biological stress in a general population of adolescent boys.

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Section: Resultssupporting

confidence: 84%

Determinants of Chronic Biological Stress, Measured as Hair Cortisol Concentration, in a General Population of Adolescents: From Individual and Household Characteristics to Neighborhood Urbanicity

Verheyen

Remy

Govarts

et al. 2021

Front. Public Health

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“…On the other hand, BPA levels were positively associated with consumption of white fish and drinks. Gys et al [62] studied the levels of bisphenols in Flemish adolescents and also found a relation between BPA levels in urine and consumption of local fish. Martinez et al [63] observed that the reduction of canned drinks during pregnancy in women from Spain was related with lower levels of BPA in urine.…”

Section: Discussionmentioning

confidence: 99%

Biomonitoring of Phthalates, Bisphenols and Parabens in Children: Exposure, Predictors and Risk Assessment

Dualde

León²,

Sanchís³

et al. 2021

IJERPH

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Exposure to emerging contaminants, such as phthalates, bisphenols and parabens in children has been associated with possible neurodevelopment and endocrine alterations. In the present study, the biomonitoring of biomarkers in children (5–12 years old) from the Valencia Region (Spain) have been implemented using urines from the BIOVAL program. More than 75% of the children studied (n = 562) were internally exposed (>LOQ) to bisphenols and parabens, and the whole population assessed (n = 557) were exposed to at least one phthalate. The geometric means (GM) of the concentrations of bisphenol A, methyl paraben and propyl paraben were 0.9, 1.4 and 0.39 ng/mL, respectively. Regarding phthalates, monoethyl phthalate GM was 55.0 ng/mL and diethyl hexyl phthalate (as the sum of five metabolites) GM was 60.6 ng/mL. Despite the studied population being widely exposed, the detection frequencies and concentrations were in general lower than in previous studies involving children in Spain and in other countries in recent years. Furthermore, the risk assessment study concluded that the internal exposure to phthalates, bisphenols and parabens is lower than the guidance values established, and, therefore, a health risk derived from the exposure to these compounds in the studied population is not expected.

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“…Most of the described analytical methods [ 13 , 14 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ] are based on the use of high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS) or tandem mass spectrometry (HPLC-MS/MS) [ 13 , 20 , 27 , 28 , 29 , 30 ], ultra-performance liquid chromatography coupled with tandem mass spectrometry [ 31 ], as well as gas chromatography coupled with mass spectrometry (GC-MS) or tandem mass spectrometry (GS-MS/MS) [ 22 , 23 , 24 , 25 , 26 , 32 ]. Previous studies detected bisphenols in amniotic fluid, follicular fluid, placental tissue, sperm, cord blood, fetal serum, adipose tissue [ 26 , 27 , 28 , 29 , 32 , 33 ], urine or peripheral blood samples [ 27 ], and human breast milk samples [ 13 , 14 , 26 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Application of Solid-Phase Extraction and High-Performance Liquid Chromatography with Fluorescence Detection to Analyze Eleven Bisphenols in Amniotic Fluid Samples Collected during Amniocentesis

Tuzimski

Szubartowski

2022

IJERPH

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Amniocentesis involves taking a sample of the amniotic fluid in order to perform a karyotype test and diagnose any genetic defects that may affect the fetus. Amniotic fluid has been collected from patients with an indication for amniocentesis in the 15–26th week of pregnancy. A simple and sensitive high-performance liquid chromatography with fluorescence detection (HPLC-FLD) method for identification and quantification of eleven selected bisphenols in amniotic fluid samples is proposed. The proposed method involved protein precipitation using acetonitrile, and next the extraction and concentration of analytes by solid-phase extraction (SPE). The solid-phase extraction (SPE) procedure with application of Oasis HLB SPE columns performed well for the majority of the analytes, with recoveries in the range of 67–121% and relative standard deviations (RSD%) less than 16%. The limits of detection (LODs) and quantification (LOQs) of all the investigated analytes were in the range of 0.8–2.5 ng mL−1 and 2.4–7.5 ng mL−1 (curves constructed in methanol) and 1.1–5.2 ng mL−1 and 3.2–15.6 ng mL−1 (curves constructed in the amniotic fluid), respectively. The method was validated at the following two concentration levels: 10 ng mL−1 (2 × LOQ) and 20 ng mL−1 (4 LOQ). The results confirm the validity of the SPE procedure and HPLC-FLD method for identification and quantification of bisphenols in amniotic fluid samples collected during an amniocentesis. The result obtained show that HPLC-FLD is a useful method for determination of bisphenol residues at nanogram per milliliter concentrations in amniotic fluid samples. Residues of five analytes (BADGE·2H2O, BPAF, BADGE, BADGE·H2O·HCl and BADGE·2HCl) were detected in amniotic fluid samples. Additionally, the harmfulness of bisphenols as potential pathogens that may cause karyotype disorders and contribute to preterm birth was estimated.

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Determinants of exposure levels of bisphenols in flemish adolescents

Cited by 31 publications

References 71 publications

Determinants of Chronic Biological Stress, Measured as Hair Cortisol Concentration, in a General Population of Adolescents: From Individual and Household Characteristics to Neighborhood Urbanicity

Determinants of Chronic Biological Stress, Measured as Hair Cortisol Concentration, in a General Population of Adolescents: From Individual and Household Characteristics to Neighborhood Urbanicity

Biomonitoring of Phthalates, Bisphenols and Parabens in Children: Exposure, Predictors and Risk Assessment

Application of Solid-Phase Extraction and High-Performance Liquid Chromatography with Fluorescence Detection to Analyze Eleven Bisphenols in Amniotic Fluid Samples Collected during Amniocentesis

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