Determinants of binding of oxidized phospholipids on apolipoprotein (a) and lipoprotein (a)

Leibundgut, Gregor; Scipione, Corey A.; Yin, Huiyong; Schneider, Matthias; Boffa, Michael B.; Green, Simone; Yang, Xiaohong; Dennis, Edward A.; Witztum, Joseph L.; Koschinsky, Marlys L.; Tsimikas, Sotirios

doi:10.1194/jlr.m040733

Cited by 177 publications

(142 citation statements)

References 64 publications

(113 reference statements)

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“…The values assigned to the calibrators were validated by both the Diasorin (Stillwater, MN) and Technoclone (Vienna, Austria) calibrators. This assay correlates well with commercially available Lp(a) assays, has a coefficient of variability of 3-5%, and has been used in more than 20 studies and 20,000 patients ( 13,(16)(17)(18)(19).…”

Section: Discussionmentioning

confidence: 98%

Population and assay thresholds for the predictive value of lipoprotein (a) for coronary artery disease: the EPIC-Norfolk Prospective Population Study

Verbeek

Boekholdt

Stoekenbroek

et al. 2016

Journal of Lipid Research

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Section: Discussionmentioning

confidence: 98%

Population and assay thresholds for the predictive value of lipoprotein (a) for coronary artery disease: the EPIC-Norfolk Prospective Population Study

Verbeek

Boekholdt

Stoekenbroek

et al. 2016

Journal of Lipid Research

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“…Both pools of negatively charged OxPL can potentially bind to SR-B1 with high affi nity ( 29 ) and thus mediate uptake and/or cholesterol effl ux. Repeating these experiments with mutant apo(a) constructs that either contain or lack OxPL ( 14 ) would be useful to further tease out the role of OxPL on Lp(a) in SR-B1. Finally, injection of [ 3 H]cholesterol-ether labeled Lp(a) into control and transgenic SR-B1 mice demonstrated greater hepatic uptake of label in transgenic mice, and in comparable experiments, decreased hepatic uptake in SR-B1 knockout mice.…”

Section: Hdl-c Abca1-mediated Cholesterol Effl Ux and Lipoprotein(amentioning

confidence: 99%

“…Furthermore, Lp(a) is the major lipoprotein carrier of oxidized phospholipids (OxPL) ( 13 ) and carries these highly immunogenic and pro-infl ammatory lipids on its LDL moiety as well as covalently bound to apo(a) ( 14 ). Lp(a) and OxPL are found in human atheromas, but more importantly, they are enriched in more advanced plaques compared with early lesions ( 15 ).…”

mentioning

confidence: 99%

HDL-C, ABCA1-mediated cholesterol efflux, and lipoprotein(a): insights into a potential novel physiologic role of lipoprotein(a)

Yeang

Tsimikas

2015

Journal of Lipid Research

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“…Subsequent lipidomics studies revealed that such oxidized phospholipids and cholesterol esters bind to apoproteins (193) and have multiple effects on macrophage signaling (194). Significantly, these oxidized species can be found in human coronary artery disease (195).…”

Section: Lipidomics Of Fatty Acids and Eicosanoidsmentioning

confidence: 99%

Liberating Chiral Lipid Mediators, Inflammatory Enzymes, and LIPID MAPS from Biological Grease

Dennis

2016

Journal of Biological Chemistry

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In 1970, it was well accepted that the central role of lipids was in energy storage and metabolism, and it was assumed that amphipathic lipids simply served a passive structural role as the backbone of biological membranes. As a result, the scientific community was focused on nucleic acids, proteins, and carbohydrates as information-containing molecules. It took considerable effort until scientists accepted that lipids also "encode" specific and unique biological information and play a central role in cell signaling. Along with this realization came the recognition that the enzymes that act on lipid substrates residing in or on membranes and micelles must also have important signaling roles, spurring curiosity into their potentially unique modes of action differing from those acting on water-soluble substrates. This led to the creation of the concept of "surface dilution kinetics" for describing the mechanism of enzymes acting on lipid substrates, as well as the demonstration that lipid enzymes such as phospholipase A 2 (PLA 2 ) contain allosteric activator sites for specific phospholipids as well as for membranes. As our understanding of phospholipases advanced, so did the understanding that many of the lipids released by these enzymes are chiral informationcontaining signaling molecules; for example, PLA 2 regulates the generation of precursors for the biosynthesis of eicosanoids and other bioactive lipid mediators of inflammation and resolution underlying disease progression. The creation of the LIPID MAPS initiative in 2003 and the ensuing development of the lipidomics field have revealed that lipid metabolites are central to human metabolism. Today lipids are recognized as key mediators of health and disease as we enter a new era of biomarkers and personalized medicine. This article is my personal "reflection" on these scientific advances.

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Determinants of binding of oxidized phospholipids on apolipoprotein (a) and lipoprotein (a)

Cited by 177 publications

References 64 publications

Population and assay thresholds for the predictive value of lipoprotein (a) for coronary artery disease: the EPIC-Norfolk Prospective Population Study

Population and assay thresholds for the predictive value of lipoprotein (a) for coronary artery disease: the EPIC-Norfolk Prospective Population Study

HDL-C, ABCA1-mediated cholesterol efflux, and lipoprotein(a): insights into a potential novel physiologic role of lipoprotein(a)

Liberating Chiral Lipid Mediators, Inflammatory Enzymes, and LIPID MAPS from Biological Grease

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