2016
DOI: 10.1074/jbc.x116.723791
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Liberating Chiral Lipid Mediators, Inflammatory Enzymes, and LIPID MAPS from Biological Grease

Abstract: In 1970, it was well accepted that the central role of lipids was in energy storage and metabolism, and it was assumed that amphipathic lipids simply served a passive structural role as the backbone of biological membranes. As a result, the scientific community was focused on nucleic acids, proteins, and carbohydrates as information-containing molecules. It took considerable effort until scientists accepted that lipids also "encode" specific and unique biological information and play a central role in cell sig… Show more

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Cited by 40 publications
(31 citation statements)
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“…Phospholipase A2 is activated by many inflammatory stimuli and acts to cleave ARA from the sn-2 position of cell membrane phospholipids, particularly phosphatidylcholine [24]. The ARA that is released acts as a substrate for cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 enzymes to form eicosanoid mediators [25][26][27].…”
Section: Arachidonic Acid and Eicosanoidsmentioning
confidence: 99%
“…Phospholipase A2 is activated by many inflammatory stimuli and acts to cleave ARA from the sn-2 position of cell membrane phospholipids, particularly phosphatidylcholine [24]. The ARA that is released acts as a substrate for cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 enzymes to form eicosanoid mediators [25][26][27].…”
Section: Arachidonic Acid and Eicosanoidsmentioning
confidence: 99%
“…To date, fluorescent lipids have been considered as mere fraction of overall liver tissue emission, relatable to fat accumulation . A step forward in the diagnostic meaning of fluorescing lipids has been promoted by 2 factors: the identification of some free fatty acids, such as arachidonic, linoleic and linolenic acids, accounting for the fluorescing lipid fraction, and the growing evidence of their roles as precursors of regulating agents of complex, protective or injuring pathways activated by hazardous stimuli . For example, prevailing anti‐inflammatory effects have been suggested for α‐linolenic acid, precursors of eicosapentaenoic acid and docosahexaenoic acid.…”
Section: Endogenous Fluorophoresmentioning
confidence: 99%
“…64,123 These findings open up important diagnostic perspectives as regards directly estimating directly the balance between AA and the miscellanea of the other FFAs, for a direct, sensitive detection of their mobilization from cell membranes or storehouses as precursors of agents regulating harmful or protective responses to hazardous stimuli. [65][66][67][68][69][70][71] Possible applications include the monitoring of oxidative events in fatty livers relevant to the risk of progression to more severe liver and extrahepatic diseases. 67,68,[124][125][126][127][128][129] With regard to bilirubin, besides investigations on molecule photoisomerization to cure hyperbilirubinemia toxicity, 61,85,130 studies on its bichromophore properties have improved its diagnostic meaning in the bile.…”
Section: Op Ti C Al B I Opsy In Hepatologymentioning
confidence: 99%
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