Determinants and risk factors of gastroenteritis in the general population, a web-based cohort between 2014 and 2017 in France

Abstract

Background: Although it is rarely fatal in developed countries, acute gastroenteritis (AGE) still induces significant morbidity and economic costs. The objective of this study was to identify factors associated with AGE in winter in the general population.Methods: A prospective study was performed during winter seasons from 2014-2015 to 2016-2017. Participants filled an inclusion survey and reported weekly data on acute symptoms. Factors associated with having at least one AGE episode per winter season were analyzed using the generalized estimating equations (GEE) approach. Results: They were 13,974 participants included in the study over the three seasons. On average, 8.1% of participants declared at least one AGE episode during a winter season. People over 60 declared fewer AGE episodes (adjusted OR (aOR)=0.76, 95% CI [0.64; 0.89]) compared to individuals between 15 and 60 years old, as well as children between 10 and 15 (aOR=0.60 [0.37; 0.98]). Overweight (aOR=1.25 [1.07; 1.45]) and obese (aOR=1.47 [1.19; 1.81]) individuals, those having frequent cold (aOR=1.63 [1.37; 1.94]) and those with at least one chronic condition (aOR=1.35 [1.16; 1.58]) had more AGE episodes. Living alone was associated with a higher AGE episode rate (aOR=1.31 [1.09; 1.59]), as well as having pets at home (aOR=1.23 [1.08; 1.41]). Conclusions: Having a better knowledge of AGE determinants will be useful to adapt public health prevention messages.

Phenome-wide analysis ofAPOL1risk variants reveals associations between one combination of haplotypes and multiple disease phenotypes in addition to chronic kidney disease

“…We re-examined the associations we identified in the phenome-wide screen between G1/G2 and poor outcomes in other infectious diseases (i.e., viral pneumonia, gram-negative bacterial sepsis, diarrhoea/gastroenteritis and viral hepatitis; Supplementary Tables 4 and 5), adjusting the covariates as appropriate for each disease [28][29][30][31] (Supplementary Table 3). Associations were detected for hospitalisation due to viral pneumonia (OR = 2.4, 95% CI: 1.2-4.6, p = 0.01), gram-negative bacterial sepsis (OR = 4.3, 95% CI: 1.4-11.9, p = 0.01), and diarrhoea/gastroenteritis of presumed infectious origin (OR = 1.9, 95% CI: 1.1-3.0, p = 0.02) (Supplementary Table 8).…”

Trends In Healthcare Visits And Antimicrobial Prescriptions For Acute Infectious Diarrhea In Individuals Aged 65 Years Or Younger In Japan From 2013 to 2018 Based On Administrative Claims Database: A Retrospective Observational Study

“…Visit rates were higher in boys than in girls and in women than in men. A higher visit rate was identi ed in women in a patient survey by the MHLW, with data obtained from the Statistics Bureau of Japan [23] and in studies from other countries [20,21,24,25]. The reason is considered to be that women generally have more contact with their children than men, increasing child-to-mother transmission.…”